Medical News

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• Weighted risk index identifies patients at high VTE risk after surgery
• Current strategies fail converted-shockable cardiac arrest patients
• Particle-based LDL predictors for CV events not better than LDL cholesterol
• Perceived negative attitude predicts psychosis transition
• Alcohol dependence has greater impact in BD I than II
• Weighted risk index identifies patients at high VTE risk after surgery
• Off-pump outcomes equivalent to standard CABG
• Benefits of recommended diabetes therapy dubious
• Family history of liver cancer may predispose to HCC
• Rise in pediatric CT prompts radiotoxicity concern
• Statin use alters osteoarthritis, RA risk
• LDL-C valuable predictor of CVD risk after statin therapy
• Family history of liver cancer may predispose to HCC
• Reduced lung function linked to diabetes risk
• Oral anticoagulant transitions risky for AF patients
• OAC self-management ‘most cost effective’
• Oral anticoagulant transitions risky for AF patients

Weighted risk index identifies patients at high VTE risk after surgery Posted: 30 Apr 2012 05:00 PM PDT A weighted risk index can be used to identify patients who are at an increased risk for venous thromboembolism after outpatient surgery, a study shows.

Current strategies fail converted-shockable cardiac arrest patients Posted: 30 Apr 2012 05:00 PM PDT Immediate defibrillation may not help cardiac arrest patients who convert from a nonshockable to a shockable rhythm during resuscitation attempts, research suggests.

Particle-based LDL predictors for CV events not better than LDL cholesterol Posted: 30 Apr 2012 05:00 PM PDT Measuring plasma apolipoprotein level and low-density lipoprotein particle number is of no additional value beyond measuring LDL cholesterol for predicting major occlusive coronary events in high-risk patients, report researchers.

Perceived negative attitude predicts psychosis transition Posted: 30 Apr 2012 05:00 PM PDT A perceived negative attitude of others to oneself predicts transition to full-blown psychosis in patients at risk for the mental health disorder, study results show.

Alcohol dependence has greater impact in BD I than II Posted: 30 Apr 2012 05:00 PM PDT Alcohol dependence has a greater negative impact on neuropsychologic functions in patients with bipolar disorder subtype I than in those with subtype II, researchers report.

Weighted risk index identifies patients at high VTE risk after surgery Posted: 30 Apr 2012 05:00 PM PDT A weighted risk index can be used to identify patients who are at an increased risk for venous thromboembolism after outpatient surgery, a study shows.

Off-pump outcomes equivalent to standard CABG Posted: 29 Apr 2012 05:00 PM PDT Off-pump coronary artery bypass grafting offers elderly cardiac patients no additional survival or quality of life benefit beyond that achieved with conventional coronary artery bypass grafting, according to Danish researchers.

Benefits of recommended diabetes therapy dubious Posted: 29 Apr 2012 05:00 PM PDT Type 2 diabetes patients do not necessarily have improved outcomes if they take a combination of metformin and insulin instead of insulin alone, report researchers.

Family history of liver cancer may predispose to HCC Posted: 29 Apr 2012 05:00 PM PDT A family history of liver cancer increases the risk for hepatocellular carcinoma independent of hepatitis, report researchers.

Rise in pediatric CT prompts radiotoxicity concern Posted: 29 Apr 2012 05:00 PM PDT There has been a dramatic increase in the use of computed tomography imaging for the assessment of children presenting to the emergency department with abdominal pain, a US study reveals.

Statin use alters osteoarthritis, RA risk Posted: 29 Apr 2012 05:00 PM PDT Lipid-lowering drugs reduce the risk for knee osteoarthritis but increase the risk for rheumatoid arthritis, suggest two studies published in the Annals of Rheumatic Diseases.

LDL-C valuable predictor of CVD risk after statin therapy Posted: 29 Apr 2012 05:00 PM PDT JUPITER post-hoc analysis results demonstrate that measuring low-density lipoprotein cholesterol levels in individuals with low cardiovascular disease risk but raised high-sensitivity C-reactive protein levels may help predict residual CVD risk after statin therapy.

Family history of liver cancer may predispose to HCC Posted: 29 Apr 2012 05:00 PM PDT A family history of liver cancer increases the risk for hepatocellular carcinoma independent of hepatitis, report researchers.

Reduced lung function linked to diabetes risk Posted: 29 Apr 2012 05:00 PM PDT Individuals with reduced lung function are at an increased risk for incident Type 2 diabetes, show study findings.

Oral anticoagulant transitions risky for AF patients Posted: 29 Apr 2012 05:00 PM PDT The risk for stroke or embolism is high when patients with atrial fibrillation transition from rivaroxaban to warfarin, shows the latest analysis of ROCKET AF.

OAC self-management ‘most cost effective’ Posted: 29 Apr 2012 05:00 PM PDT Self-management of long-term oral anticoagulation may be the most clinically beneficial and cost-effective approach, Belgian researchers believe.

Oral anticoagulant transitions risky for AF patients Posted: 29 Apr 2012 05:00 PM PDT The risk for stroke or embolism is high when patients with atrial fibrillation transition from rivaroxaban to warfarin, shows the latest analysis of ROCKET AF.

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Medical News

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• Structured primary care algorithm significantly improves BP control
• Structured primary care algorithm significantly improves BP control
• Single ultrasonography scan could rule out pregnancy-related DVT
• Contraceptive use linked to current mood disorder risk in women
• Reduced early teenage premorbid functioning in schizophrenia
• Differential age-related amygdala response to facial emotions in BD
• Early weaning does not prevent HIV infection in infants
• Maternal gliadin antibodies linked to psychosis risk in offspring
• Anxiety disorders common in bipolar patients
• Global measles mortality has dropped, but still room for improvement
• Prefrontal oscillatory frequency reduced in schizophrenia patients
• Mood state linked to amygdala volume in bipolar patients
• Study supports psychosis continuum

Structured primary care algorithm significantly improves BP control Posted: 29 Apr 2012 05:00 PM PDT A structured computer-based algorithm could significantly improve blood pressure control among patients in primary care, a study suggests.

Structured primary care algorithm significantly improves BP control Posted: 29 Apr 2012 05:00 PM PDT A structured computer-based algorithm could significantly improve blood pressure control among patients in primary care, a study suggests.

Single ultrasonography scan could rule out pregnancy-related DVT Posted: 29 Apr 2012 05:00 PM PDT A single complete compression ultrasonography result may "safely" exclude the diagnosis of deep vein thrombosis in pregnant and postpartum women, a study shows.

Contraceptive use linked to current mood disorder risk in women Posted: 26 Apr 2012 05:00 PM PDT The use of progestin-only contraceptives is associated with an increased risk for current mood disorders in women, while the use of combined estrogen and progestin contraceptive agents is associated with a reduced risk, study results suggest.

Reduced early teenage premorbid functioning in schizophrenia Posted: 26 Apr 2012 05:00 PM PDT Children who go on to develop schizophrenia in adulthood have poorer premorbid nonacademic performance and show poorer behavioural ratings compared with their peers who remain mentally healthy, Israeli researchers report.

Differential age-related amygdala response to facial emotions in BD Posted: 25 Apr 2012 05:00 PM PDT Children with bipolar disorder show greater activation of the right amygdala when viewing facial expressions of emotion compared with mentally healthy children and adults with the mood disorder, researchers report.

Early weaning does not prevent HIV infection in infants Posted: 25 Apr 2012 05:00 PM PDT Stopping breastfeeding early does not prevent mother-to-child HIV transmission and significantly increases the infant's likelihood for illness, growth problems, and death, show study data published in The Lancet.

Maternal gliadin antibodies linked to psychosis risk in offspring Posted: 25 Apr 2012 05:00 PM PDT High maternal levels of antigliadin immunoglobulin G in later pregnancy are associated with an increased risk for nonaffective psychosis in offspring, Swedish study results show.

Anxiety disorders common in bipolar patients Posted: 24 Apr 2012 05:00 PM PDT Anxiety disorders are highly prevalent in patients with bipolar disorder and are associated with increased mood symptoms, study results show.

Global measles mortality has dropped, but still room for improvement Posted: 24 Apr 2012 05:00 PM PDT Mortality from measles has decreased dramatically between 2000 and 2010, but rates could still be improved, show study results.

Prefrontal oscillatory frequency reduced in schizophrenia patients Posted: 24 Apr 2012 05:00 PM PDT Patients with schizophrenia show a slower natural oscillatory frequency in the prefrontal cortex of the brain compared with mentally healthy individuals, report researchers.

Mood state linked to amygdala volume in bipolar patients Posted: 23 Apr 2012 05:00 PM PDT Depressed patients with bipolar disorder show reduced amygdala volume compared with euthymic patients and mentally healthy individuals, report researchers.

Study supports psychosis continuum Posted: 23 Apr 2012 05:00 PM PDT Individuals with nonclinical psychosis symptoms show increased levels of depression and dermatoglyphic asymmetries, and patterns of procedural learning similar to those found in patients with diagnosed psychosis, report researchers.

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Medical News

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• Heart at center of systemic metabolism
• COPD negatively affects retina and optical nerve
• In-hospital PE deaths remain stable in US
• In-hospital PE deaths remain stable in US

Heart at center of systemic metabolism Posted: 26 Apr 2012 05:00 PM PDT Modulating a cardiac-specific thyroid hormone signaling pathway may have metabolic benefits for the whole body, researchers have found.

COPD negatively affects retina and optical nerve Posted: 26 Apr 2012 05:00 PM PDT Chronic obstructive pulmonary disease could have negative effects on patients' retinas and optical nerves, say Turkish researchers.

In-hospital PE deaths remain stable in US Posted: 26 Apr 2012 05:00 PM PDT The estimated annual number of in-hospital deaths among patients with a pulmonary embolism diagnosis has remained relatively stable during recent years, despite a decline in case-fatality rates, US study data show.

In-hospital PE deaths remain stable in US Posted: 26 Apr 2012 05:00 PM PDT The estimated annual number of in-hospital deaths among patients with a pulmonary embolism diagnosis has remained relatively stable during recent years, despite a decline in case-fatality rates, US study data show.

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Medical News

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• Adenotonsillectomy in under-3s has low complication rate
• QRS width could predict SCA in CAD patients
• CT scan before angioplasty increases door-to-balloon time
• Incretin-based therapy effective as add-on to metformin
• Link between lipoprotein(a), CVD identified
• Contraceptive use linked to current mood disorder risk in women
• Ustekinumab well tolerated, effective in PHOENIX 1
• Methamphetamine, MDMA use increases risk for depressive symptoms
• Contraceptive use linked to current mood disorder risk in women
• Reduced early teenage premorbid functioning in schizophrenia
• Seizures may impact stroke thrombolysis outcomes
• Liver transplantation validated for select chemoradiation-treated cancer patients
• Adenocarcinoma prognosis best predicted using solid tumor size
• Positive serum mesothelin indicator for further tests
• TKIs improve survival in EGFR mutation positive lung cancer
• Pemetrexed maintains quality of life in non-small-cell lung cancer
• Adenocarcinoma prognosis best predicted using solid tumor size
• Positive serum mesothelin indicator for further tests
• TKIs improve survival in EGFR mutation positive lung cancer
• Pemetrexed maintains quality of life in non-small-cell lung cancer
• Liver transplantation validated for select chemoradiation-treated cancer patients
• <i>P16</i> gene alterations signal aggressive buccal carcinoma

Adenotonsillectomy in under-3s has low complication rate Posted: 26 Apr 2012 05:00 PM PDT Adenotonsillectomy has a very low complication rate in children aged 3 years and under, a US retrospective study has found.

QRS width could predict SCA in CAD patients Posted: 26 Apr 2012 05:00 PM PDT Broad width QRS measurements could indicate the potential for sudden cardiac arrest in patients with coronary artery disease, show Dutch study results.

CT scan before angioplasty increases door-to-balloon time Posted: 26 Apr 2012 05:00 PM PDT Computed tomography scanning before a primary percutaneous coronary intervention procedure is associated with significantly longer door-to-balloon times, researchers suggest.

Incretin-based therapy effective as add-on to metformin Posted: 26 Apr 2012 05:00 PM PDT Incretin-based therapy is effective at improving glycemic control when added to metformin treatment in patients with Type 2 diabetes, show study findings.

Link between lipoprotein(a), CVD identified Posted: 26 Apr 2012 05:00 PM PDT Genetic study results indicate that lipoprotein may raise cardiovascular disease risk by encouraging atherosclerotic stenosis rather than venous thrombosis.

Contraceptive use linked to current mood disorder risk in women Posted: 26 Apr 2012 05:00 PM PDT The use of progestin-only contraceptives is associated with an increased risk for current mood disorders in women, while the use of combined estrogen and progestin contraceptive agents is associated with a reduced risk, study results suggest.

Ustekinumab well tolerated, effective in PHOENIX 1 Posted: 26 Apr 2012 05:00 PM PDT Extended results from the PHOENIX 1 study suggest that ustekinumab is an effective and well-tolerated therapy for moderate-to-severe psoriasis for up to 3 years.

Methamphetamine, MDMA use increases risk for depressive symptoms Posted: 26 Apr 2012 05:00 PM PDT Adolescents who use methamphetamine or methylenedioxy-methamphetamine are at risk for developing subsequent depressive symptoms, suggest study findings.

Contraceptive use linked to current mood disorder risk in women Posted: 26 Apr 2012 05:00 PM PDT The use of progestin-only contraceptives is associated with an increased risk for current mood disorders in women, while the use of combined estrogen and progestin contraceptive agents is associated with a reduced risk, study results suggest.

Reduced early teenage premorbid functioning in schizophrenia Posted: 26 Apr 2012 05:00 PM PDT Children who go on to develop schizophrenia in adulthood have poorer premorbid nonacademic performance and show poorer behavioural ratings compared with their peers who remain mentally healthy, Israeli researchers report.

Seizures may impact stroke thrombolysis outcomes Posted: 26 Apr 2012 05:00 PM PDT Anticonvulsant medication could improve outcomes after thrombolysis in patients with acute stroke, say researchers who found an association between seizures and poor outcome.

Liver transplantation validated for select chemoradiation-treated cancer patients Posted: 25 Apr 2012 05:00 PM PDT Research supports the use of orthotopic liver transplantation after chemoradiation in select patients with unresectable perihilar cholangiocarcinoma.

Adenocarcinoma prognosis best predicted using solid tumor size Posted: 25 Apr 2012 05:00 PM PDT Study findings suggest that preoperative high-resolution computed tomography solid tumor size is better than whole tumor size for predicting high-grade malignancy and prognosis in clinical stage IA lung adenocarcinoma.

Positive serum mesothelin indicator for further tests Posted: 25 Apr 2012 05:00 PM PDT Patients with suspected mesothelioma testing positive for serum mesothelin should undergo further diagnostic tests for malignant pleural mesothelioma, suggest findings from a meta-analysis.

TKIs improve survival in EGFR mutation positive lung cancer Posted: 25 Apr 2012 05:00 PM PDT European patients with mutation-positive epidermal growth factor receptor non small cell lung cancer should undergo routine baseline tissue-based mutation assessment and treatment with EGFR tyrosine-kinase inhibitors, suggest study findings.

Pemetrexed maintains quality of life in non-small-cell lung cancer Posted: 25 Apr 2012 05:00 PM PDT Patients with advanced non-small-cell lung cancer treated with pemetrexed maintenance therapy show good symptom control and no significant detriment to quality of life, research shows.

Adenocarcinoma prognosis best predicted using solid tumor size Posted: 25 Apr 2012 05:00 PM PDT Study findings suggest that preoperative high-resolution computed tomography solid tumor size is better than whole tumor size for predicting high-grade malignancy and prognosis in clinical stage IA lung adenocarcinoma.

Positive serum mesothelin indicator for further tests Posted: 25 Apr 2012 05:00 PM PDT Patients with suspected mesothelioma testing positive for serum mesothelin should undergo further diagnostic tests for malignant pleural mesothelioma, suggest findings from a meta-analysis.

TKIs improve survival in EGFR mutation positive lung cancer Posted: 25 Apr 2012 05:00 PM PDT European patients with mutation-positive epidermal growth factor receptor non small cell lung cancer should undergo routine baseline tissue-based mutation assessment and treatment with EGFR tyrosine-kinase inhibitors, suggest study findings.

Pemetrexed maintains quality of life in non-small-cell lung cancer Posted: 25 Apr 2012 05:00 PM PDT Patients with advanced non-small-cell lung cancer treated with pemetrexed maintenance therapy show good symptom control and no significant detriment to quality of life, research shows.

Liver transplantation validated for select chemoradiation-treated cancer patients Posted: 25 Apr 2012 05:00 PM PDT Research supports the use of orthotopic liver transplantation after chemoradiation in select patients with unresectable perihilar cholangiocarcinoma.

<i>P16</i> gene alterations signal aggressive buccal carcinoma Posted: 25 Apr 2012 05:00 PM PDT Alterations in the tumor-suppressor gene P16 are involved in the development of a particularly aggressive form of squamous cell carcinoma of the buccal mucosa, study findings suggest.

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