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• Multiple aspects to severe bipolar mixed states
• Carbonyl stress suggests strategy for treatment-resistant schizophrenia
• Multiple aspects to severe bipolar mixed states
• Precise value of EXACT in COPD uncertain
• Carbonyl stress suggests strategy for treatment-resistant schizophrenia

Multiple aspects to severe bipolar mixed states Posted: 30 Sep 2013 05:00 PM PDT Researchers have identified four subgroups of severe bipolar mixed states, characterized by distinct symptomatologic presentations.

Carbonyl stress suggests strategy for treatment-resistant schizophrenia Posted: 30 Sep 2013 05:00 PM PDT Patients with schizophrenia who have enhanced carbonyl stress have clinical features associated with treatment resistance, say researchers.

Multiple aspects to severe bipolar mixed states Posted: 30 Sep 2013 05:00 PM PDT Researchers have identified four subgroups of severe bipolar mixed states, characterized by distinct symptomatologic presentations.

Precise value of EXACT in COPD uncertain Posted: 30 Sep 2013 05:00 PM PDT EXACT is effective in assessing exacerbations of chronic obstructive pulmonary disease in the outpatient setting, a study shows.

Carbonyl stress suggests strategy for treatment-resistant schizophrenia Posted: 30 Sep 2013 05:00 PM PDT Patients with schizophrenia who have enhanced carbonyl stress have clinical features associated with treatment resistance, say researchers.

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• Central BP achieves the same with less
• LRTI and CAP incidence underestimated in oldest citizens
• Use of <i>SHOX2</i> DNA measurement improves cancer staging tools
• Intercalated erlotinib/chemotherapy shows mixed results in NSCLC
• Use of <i>SHOX2</i> DNA measurement improves cancer staging tools
• Intercalated erlotinib/chemotherapy shows mixed results in NSCLC
• Vitamin D levels linked to emphysema
• Inpatient PSA levels ‘should be disregarded’ for prostate monitoring
• Tool guides lymph node surgery in Asian prostate cancer patients

Central BP achieves the same with less Posted: 29 Sep 2013 05:00 PM PDT Using central, rather than brachial, blood pressure (BP) to guide treatment decisions results in patients with hypertension being given less medication, show results from a randomized trial.

LRTI and CAP incidence underestimated in oldest citizens Posted: 29 Sep 2013 05:00 PM PDT Data from the UK indicate that statistics on lower respiratory tract infection and community-acquired pneumonia in the over 65s probably underestimate their burden in the oldest patients.

Use of <i>SHOX2</i> DNA measurement improves cancer staging tools Posted: 29 Sep 2013 05:00 PM PDT Findings indicate that assessment of SHOX2 DNA methylation level in lymph node tissue improves the negative predictive value of endobronchial ultrasound with transbronchial needle aspiration, as well as endoscopic lung cancer staging in general.

Intercalated erlotinib/chemotherapy shows mixed results in NSCLC Posted: 29 Sep 2013 05:00 PM PDT A study comparing erlotinib alone with erlotinib intercalated with chemotherapy has failed to demonstrate a clear advantage of the combination strategy when used to treat relapsed patients with non-small-cell lung cancer, Dutch researchers report.

Use of <i>SHOX2</i> DNA measurement improves cancer staging tools Posted: 29 Sep 2013 05:00 PM PDT Findings indicate that assessment of SHOX2 DNA methylation level in lymph node tissue improves the negative predictive value of endobronchial ultrasound with transbronchial needle aspiration, as well as endoscopic lung cancer staging in general.

Intercalated erlotinib/chemotherapy shows mixed results in NSCLC Posted: 29 Sep 2013 05:00 PM PDT A study comparing erlotinib alone with erlotinib intercalated with chemotherapy has failed to demonstrate a clear advantage of the combination strategy when used to treat relapsed patients with non-small-cell lung cancer, Dutch researchers report.

Vitamin D levels linked to emphysema Posted: 29 Sep 2013 05:00 PM PDT Researchers have found a relationship between emphysema and serum vitamin D levels, suggesting that the vitamin may play a role in modulating lung structure.

Inpatient PSA levels ‘should be disregarded’ for prostate monitoring Posted: 29 Sep 2013 05:00 PM PDT Researchers from Korea say that inpatient prostate-specific antigen levels should be ignored for the purposes of serial monitoring, after finding that they are significantly reduced compared with outpatient levels.

Tool guides lymph node surgery in Asian prostate cancer patients Posted: 29 Sep 2013 05:00 PM PDT Researchers from Korea have developed a nomogram that predicts which Asian men with prostate cancer are most at risk for lymph node (LN) invasion.

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Cleaning product-related asthma goes beyond irritation Posted: 26 Sep 2013 05:00 PM PDT Research from Belgium indicates that a substantial proportion of those who have occupational asthma related to cleaning agents have specific airway sensitivity to the components of detergents.

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• Exercise interventions may be needed in bipolar patients
• Time to first cigarette independently predicts lung cancer
• Immunologic checkpoint inhibitor shows promise in malignant mesothelioma
• Time to first cigarette independently predicts lung cancer
• Immunologic checkpoint inhibitor shows promise in malignant mesothelioma
• Exercise interventions may be needed in bipolar patients
• Short insight scale validated for schizophrenia in clinical practice
• Time to first cigarette independently predicts lung cancer
• Short insight scale validated for schizophrenia in clinical practice
• Icotinib matches gefitinib in NSCLC second or third line
• Icotinib matches gefitinib in NSCLC second or third line

Exercise interventions may be needed in bipolar patients Posted: 26 Sep 2013 05:00 PM PDT An accelerometry study shows that patients with bipolar disorder tend to be mostly sedentary.

Time to first cigarette independently predicts lung cancer Posted: 26 Sep 2013 05:00 PM PDT The time to first cigarette after waking is an independent risk factor for lung cancer, a Japanese case-control study has found.

Immunologic checkpoint inhibitor shows promise in malignant mesothelioma Posted: 26 Sep 2013 05:00 PM PDT Tremelimumab, one of a new class of immunomodulatory monoclonal antibodies, has shown encouraging clinical activity and acceptable tolerability in patients with chemotherapy-resistant malignant mesothelioma, results of a single-arm phase II study show.

Time to first cigarette independently predicts lung cancer Posted: 26 Sep 2013 05:00 PM PDT The time to first cigarette after waking is an independent risk factor for lung cancer, a Japanese case-control study has found.

Immunologic checkpoint inhibitor shows promise in malignant mesothelioma Posted: 26 Sep 2013 05:00 PM PDT Tremelimumab, one of a new class of immunomodulatory monoclonal antibodies, has shown encouraging clinical activity and acceptable tolerability in patients with chemotherapy-resistant malignant mesothelioma, results of a single-arm phase II study show.

Exercise interventions may be needed in bipolar patients Posted: 26 Sep 2013 05:00 PM PDT An accelerometry study shows that patients with bipolar disorder tend to be mostly sedentary.

Short insight scale validated for schizophrenia in clinical practice Posted: 26 Sep 2013 05:00 PM PDT Researchers have validated a short version of the Scale to Assess Unawareness in Mental Disorder, with the aim of encouraging assessment of insight in patients with schizophrenia in clinical practice.

Time to first cigarette independently predicts lung cancer Posted: 26 Sep 2013 05:00 PM PDT The time to first cigarette after waking is an independent risk factor for lung cancer, a Japanese case-control study has found.

Short insight scale validated for schizophrenia in clinical practice Posted: 26 Sep 2013 05:00 PM PDT Researchers have validated a short version of the Scale to Assess Unawareness in Mental Disorder, with the aim of encouraging assessment of insight in patients with schizophrenia in clinical practice.

Icotinib matches gefitinib in NSCLC second or third line Posted: 25 Sep 2013 05:00 PM PDT Icotinib has been found to be noninferior to gefitinib in patients with non-small-cell lung cancer, according to reports from the phase III Chinese double-blind ICOGEN study.

Icotinib matches gefitinib in NSCLC second or third line Posted: 25 Sep 2013 05:00 PM PDT Icotinib has been found to be noninferior to gefitinib in patients with non-small-cell lung cancer, according to reports from the phase III Chinese double-blind ICOGEN study.

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• <i>T. gondii</i> antibodies implicated in mania
• <i>T. gondii</i> antibodies implicated in mania
• Drug misuse predicts protracted hospital stay for schizophrenia patients
• Chronic bronchitis linked to poor asthma outcomes
• Drug misuse predicts protracted hospital stay for schizophrenia patients
• Reduced physical activity in COPD not just disease related
• Clinical SAH decision rule refined

<i>T. gondii</i> antibodies implicated in mania Posted: 25 Sep 2013 05:00 PM PDT Infection with Toxoplasma gondii may confer an increased risk for mania, say researchers.

<i>T. gondii</i> antibodies implicated in mania Posted: 25 Sep 2013 05:00 PM PDT Infection with Toxoplasma gondii may confer an increased risk for mania, say researchers.

Drug misuse predicts protracted hospital stay for schizophrenia patients Posted: 25 Sep 2013 05:00 PM PDT Patients hospitalized with schizophrenia have more severe symptoms and spend longer in hospital if they have a concurrent substance use disorder, report researchers.

Chronic bronchitis linked to poor asthma outcomes Posted: 25 Sep 2013 05:00 PM PDT Researchers have found that chronic bronchitis is associated with worse clinical outcomes in asthma, particularly among smokers.

Drug misuse predicts protracted hospital stay for schizophrenia patients Posted: 25 Sep 2013 05:00 PM PDT Patients hospitalized with schizophrenia have more severe symptoms and spend longer in hospital if they have a concurrent substance use disorder, report researchers.

Reduced physical activity in COPD not just disease related Posted: 24 Sep 2013 05:00 PM PDT Researchers from the Netherlands have shown that physical activity in patients with chronic obstructive pulmonary disease is influenced by both physical and psychosocial factors.

Clinical SAH decision rule refined Posted: 24 Sep 2013 05:00 PM PDT Researchers have consolidated their previously published decision rules for subarachnoid hemorrhage into a single rule with 100% sensitivity.

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• Stroke warning for bipolar patients
• Stroke warning for bipolar patients
• Early intermodality dysfunction predicts schizophrenia risk
• Stroke warning for bipolar patients
• Early intermodality dysfunction predicts schizophrenia risk
• Metastatic site impacts survival in targeted RCC treatment
• Inflammatory marker may highlight aggressive RCC treatment need
• Amendment to renal cancer TNM staging proposed
• Immune marker prognostic after non-clear cell RCC surgery
• Major role for body weight in COPD, asthma risk

Stroke warning for bipolar patients Posted: 24 Sep 2013 05:00 PM PDT Patients with bipolar disorder are at an increased risk for having a stroke and for dying soon after their stroke, a study shows.

Stroke warning for bipolar patients Posted: 24 Sep 2013 05:00 PM PDT Patients with bipolar disorder are at an increased risk for having a stroke and for dying soon after their stroke, a study shows.

Early intermodality dysfunction predicts schizophrenia risk Posted: 24 Sep 2013 05:00 PM PDT Researchers have found abnormalities in the way infants of parents with schizophrenia perceive the way they move and how this relates to vision, touch, hearing, and orientation.

Stroke warning for bipolar patients Posted: 24 Sep 2013 05:00 PM PDT Patients with bipolar disorder are at an increased risk for having a stroke and for dying soon after their stroke, a study shows.

Early intermodality dysfunction predicts schizophrenia risk Posted: 24 Sep 2013 05:00 PM PDT Researchers have found abnormalities in the way infants of parents with schizophrenia perceive the way they move and how this relates to vision, touch, hearing, and orientation.

Metastatic site impacts survival in targeted RCC treatment Posted: 23 Sep 2013 05:00 PM PDT Bone and liver metastases may have the heaviest impact on the survival of patients receiving targeted therapy for metastatic renal cell carcinoma, suggest data from the International Metastatic Renal Cell Carcinoma Database Consortium.

Inflammatory marker may highlight aggressive RCC treatment need Posted: 23 Sep 2013 05:00 PM PDT Patients with metastatic renal cell carcinoma who have high preoperative levels of the inflammatory marker C-reactive protein may need intensive multimodal treatment to optimize their survival, say researchers.

Amendment to renal cancer TNM staging proposed Posted: 23 Sep 2013 05:00 PM PDT Patients with pT3a renal cell carcinoma have markedly worse survival rates if they have both fat invasion and renal vein thrombosis, rather than just one of these factors, a study shows.

Immune marker prognostic after non-clear cell RCC surgery Posted: 23 Sep 2013 05:00 PM PDT The preoperative neutrophil-to-lymphocyte ratio is associated with disease-free survival in patients undergoing resection of localized non-clear cell renal cell carcinoma, research shows.

Major role for body weight in COPD, asthma risk Posted: 23 Sep 2013 05:00 PM PDT Results from a large study in Italy show that increasing body weight is associated with chronic obstructive pulmonary disease and asthma risk, independent of smoking history.

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• Inflammation tracks mania course
• Dental caries show ‘unexpected’ relationship with head and neck cancer
• Inflammation tracks mania course
• Prefrontal glutamate abnormalities confined to established psychosis
• Prefrontal glutamate abnormalities confined to established psychosis
• Mild COPD phenotype discovery offers treatment hope

Inflammation tracks mania course Posted: 23 Sep 2013 05:00 PM PDT Markers of inflammation are elevated in patients who are hospitalized for acute mania, a study shows.

Dental caries show ‘unexpected’ relationship with head and neck cancer Posted: 23 Sep 2013 05:00 PM PDT People with dental caries have a reduced risk for developing head and neck squamous cell carcinoma, a large case-control study has found.

Inflammation tracks mania course Posted: 23 Sep 2013 05:00 PM PDT Markers of inflammation are elevated in patients who are hospitalized for acute mania, a study shows.

Prefrontal glutamate abnormalities confined to established psychosis Posted: 23 Sep 2013 05:00 PM PDT Abnormalities in glutamate and glutamine levels in the prefrontal cortex are only present in patients with chronic schizophrenia, say researchers.

Prefrontal glutamate abnormalities confined to established psychosis Posted: 23 Sep 2013 05:00 PM PDT Abnormalities in glutamate and glutamine levels in the prefrontal cortex are only present in patients with chronic schizophrenia, say researchers.

Mild COPD phenotype discovery offers treatment hope Posted: 22 Sep 2013 05:00 PM PDT Research indicates that smokers with and without mild chronic obstructive pulmonary disease can be classified into distinct phenotypes on the basis of computed tomography findings.

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• Framingham model predicts hypertension in young adults
• Urinary pneumococcal antigen testing ‘useful in children’
• Sleep disturbances may influence vascular cognitive decline
• Surgery shows first-line potential for stress urinary incontinence
• QoL questionnaire predicts nocturia, risk for falling

Framingham model predicts hypertension in young adults Posted: 22 Sep 2013 05:00 PM PDT The Framingham Heart Study model for predicting short-term risk for hypertension has good discriminatory ability in a biracial population of young adults, say researchers.

Urinary pneumococcal antigen testing ‘useful in children’ Posted: 22 Sep 2013 05:00 PM PDT Urinary antigen testing is effective in detecting invasive pneumococcal pneumonia in children, say the authors of a UK-based case–control study.

Sleep disturbances may influence vascular cognitive decline Posted: 22 Sep 2013 05:00 PM PDT Patients with vascular cognitive impairment without dementia have distinct abnormal sleep patterns that may be related to their cognitive deficits, researchers report.

Surgery shows first-line potential for stress urinary incontinence Posted: 22 Sep 2013 05:00 PM PDT The authors of a head-to-head study say that surgery should be considered as a first-line option for women with stress urinary incontinence, ahead of physiotherapy.

QoL questionnaire predicts nocturia, risk for falling Posted: 22 Sep 2013 05:00 PM PDT A study of Japanese outpatients highlights the association between nighttime voiding and bone fractures, after showing that the Nocturia Quality-of-Life questionnaire can identify patients at risk for both.

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