Medical News

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• BDNF abnormalities may predict bipolar disorder
• Tooth extraction before heart surgery carries risks
• Gastric bypass better than gastrectomy for GERD relief
• Plasma microRNA test boosts lung cancer screening
• Plasma microRNA test boosts lung cancer screening
• BDNF abnormalities may predict bipolar disorder
• Elevated homocysteine not gender-specific in schizophrenia
• Elevated homocysteine not gender-specific in schizophrenia

BDNF abnormalities may predict bipolar disorder Posted: 27 Feb 2014 04:00 PM PST Patients with bipolar disorder show abnormalities in the conversion of pro-brain derived neurotrophic factor to the mature form, which may be used to aid diagnosis of the condition.

Tooth extraction before heart surgery carries risks Posted: 27 Feb 2014 04:00 PM PST Dental extraction before cardiac surgery may not be as benign a procedure as some clinicians might think, with review findings showing that it is associated with major adverse outcomes.

Gastric bypass better than gastrectomy for GERD relief Posted: 27 Feb 2014 04:00 PM PST Patients who are about to undergo bariatric surgery may be better off having a gastric bypass than a sleeve gastrectomy if they also suffer from heartburn, results of a large US analysis suggest.

Plasma microRNA test boosts lung cancer screening Posted: 27 Feb 2014 04:00 PM PST The ability to screen for lung cancer is improved by the development of a plasma 24-microRNA signature classifier, research suggests.

Plasma microRNA test boosts lung cancer screening Posted: 27 Feb 2014 04:00 PM PST The ability to screen for lung cancer is improved by the development of a plasma 24-microRNA signature classifier, research suggests.

BDNF abnormalities may predict bipolar disorder Posted: 27 Feb 2014 04:00 PM PST Patients with bipolar disorder show abnormalities in the conversion of pro-brain derived neurotrophic factor to the mature form, which may be used to aid diagnosis of the condition.

Elevated homocysteine not gender-specific in schizophrenia Posted: 27 Feb 2014 04:00 PM PST Japanese researchers have demonstrated that both men and women with schizophrenia have significantly higher plasma homocysteine levels than healthy controls.

Elevated homocysteine not gender-specific in schizophrenia Posted: 27 Feb 2014 04:00 PM PST Japanese researchers have demonstrated that both men and women with schizophrenia have significantly higher plasma homocysteine levels than healthy controls.

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• Advanced paternal age effects extend to several psychiatric disorders
• Further support for hippocampal volume as psychosis biomarker
• H4 receptor activation plays part in NSCLC progression
• H4 receptor activation plays part in NSCLC progression
• Advanced paternal age effects extend to several psychiatric disorders
• Further support for hippocampal volume as psychosis biomarker
• Further support for hippocampal volume as psychosis biomarker

Advanced paternal age effects extend to several psychiatric disorders Posted: 26 Feb 2014 04:00 PM PST The effect of advanced paternal age at childbearing on the psychiatric morbidity risk of their children extends to several psychiatric disorders and particularly bipolar disorder, findings from a sibling-comparison study show.

Further support for hippocampal volume as psychosis biomarker Posted: 26 Feb 2014 04:00 PM PST Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes provide further evidence that reduced hippocampal volume is a consistent feature of schizophrenia.

H4 receptor activation plays part in NSCLC progression Posted: 26 Feb 2014 04:00 PM PST Histamine H4 receptor activation decreases epithelial-to-mesenchymal transmission in non-small-cell lung cancer, Chinese research shows.

H4 receptor activation plays part in NSCLC progression Posted: 26 Feb 2014 04:00 PM PST Histamine H4 receptor activation decreases epithelial-to-mesenchymal transmission in non-small-cell lung cancer, Chinese research shows.

Advanced paternal age effects extend to several psychiatric disorders Posted: 26 Feb 2014 04:00 PM PST The effect of advanced paternal age at childbearing on the psychiatric morbidity risk of their children extends to several psychiatric disorders and particularly bipolar disorder, findings from a sibling-comparison study show.

Further support for hippocampal volume as psychosis biomarker Posted: 26 Feb 2014 04:00 PM PST Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes provide further evidence that reduced hippocampal volume is a consistent feature of schizophrenia.

Further support for hippocampal volume as psychosis biomarker Posted: 26 Feb 2014 04:00 PM PST Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes provide further evidence that reduced hippocampal volume is a consistent feature of schizophrenia.

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• Residual symptoms linked to poor functioning in euthymic bipolar disorder
• Novel SCLC tumour suppressor gene discovered
• Novel SCLC tumour suppressor gene discovered
• Residual symptoms linked to poor functioning in euthymic bipolar disorder
• Attitudinal beliefs feed negative schizophrenia symptoms
• Attitudinal beliefs feed negative schizophrenia symptoms

Residual symptoms linked to poor functioning in euthymic bipolar disorder Posted: 25 Feb 2014 04:00 PM PST Residual symptoms are associated with functional impairment in euthymic individuals with bipolar disorder, a large observational study has shown.

Novel SCLC tumour suppressor gene discovered Posted: 25 Feb 2014 04:00 PM PST Inactivation of the MYC-associated factor X gene, MAX, may play a significant role in the development of small-cell lung cancer, scientists believe.

Novel SCLC tumour suppressor gene discovered Posted: 25 Feb 2014 04:00 PM PST Inactivation of the MYC-associated factor X gene, MAX, may play a significant role in the development of small-cell lung cancer, scientists believe.

Residual symptoms linked to poor functioning in euthymic bipolar disorder Posted: 25 Feb 2014 04:00 PM PST Residual symptoms are associated with functional impairment in euthymic individuals with bipolar disorder, a large observational study has shown.

Attitudinal beliefs feed negative schizophrenia symptoms Posted: 25 Feb 2014 04:00 PM PST Dysfunctional attitudes and low self-efficacy are associated with poorer functioning in patients with early schizophrenia, and this relationship is partly mediated by negative symptoms, shows research.

Attitudinal beliefs feed negative schizophrenia symptoms Posted: 25 Feb 2014 04:00 PM PST Dysfunctional attitudes and low self-efficacy are associated with poorer functioning in patients with early schizophrenia, and this relationship is partly mediated by negative symptoms, shows research.

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• Psychoeducation reduces internalised stigmatisation in bipolar patients
• Psychoeducation reduces internalised stigmatisation in bipolar patients
• Substance abuse worsens course of first-episode psychosis
• Substance abuse worsens course of first-episode psychosis

Psychoeducation reduces internalised stigmatisation in bipolar patients Posted: 24 Feb 2014 04:00 PM PST A psychoeducation program designed to reduce internalised stigmatisation in patients with bipolar disease resulted in a significant decrease in total mean scores on the Internalized Stigmatization Scale of Mental Illness compared with a control group, a Turkish study shows.

Psychoeducation reduces internalised stigmatisation in bipolar patients Posted: 24 Feb 2014 04:00 PM PST A psychoeducation program designed to reduce internalised stigmatisation in patients with bipolar disease resulted in a significant decrease in total mean scores on the Internalized Stigmatization Scale of Mental Illness compared with a control group, a Turkish study shows.

Substance abuse worsens course of first-episode psychosis Posted: 24 Feb 2014 04:00 PM PST Patients with first-episode psychosis who also present with substance abuse have a higher rate of hospitalisation after 12 months than their peers who do not, an Italian study reports.

Substance abuse worsens course of first-episode psychosis Posted: 24 Feb 2014 04:00 PM PST Patients with first-episode psychosis who also present with substance abuse have a higher rate of hospitalisation after 12 months than their peers who do not, an Italian study reports.

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• Treatable factors linked to blood pressure variability in diabetes
• Treatable factors linked to blood pressure variability in diabetes
• <i>S. pneumoniae</i> highly prevalent in urban Indonesians, especially children
• Perioperative blood transfusion worsens kidney cancer patients’ survival
• Partial nephrectomy may offer younger renal cancer patients survival advantage
• Sedentary behaviour has unclear link with prostate cancer risk
• Sedentary behaviour has unclear link with prostate cancer risk
• Treatment targets beyond OA found for widespread pain onset
• Perioperative blood transfusion worsens kidney cancer patients’ survival
• Partial nephrectomy may offer younger renal cancer patients survival advantage
• Detrusor muscle function declines with age
• Sedentary behaviour has unclear link with prostate cancer risk

Treatable factors linked to blood pressure variability in diabetes Posted: 23 Feb 2014 04:00 PM PST Some factors that are associated with variability in home blood pressure in patients with Type 2 diabetes may be open to intervention, research suggests.

Treatable factors linked to blood pressure variability in diabetes Posted: 23 Feb 2014 04:00 PM PST Some factors that are associated with variability in home blood pressure in patients with Type 2 diabetes may be open to intervention, research suggests.

<i>S. pneumoniae</i> highly prevalent in urban Indonesians, especially children Posted: 23 Feb 2014 04:00 PM PST Streptococcus pneumoniae is present in the nasopharyngeal mucosa in nearly half of children under the age of 5 years and one in 10 adults living in Java Island, Indonesia, a survey has found.

Perioperative blood transfusion worsens kidney cancer patients’ survival Posted: 23 Feb 2014 04:00 PM PST Patients who receive blood transfusions around the time of their surgery for nonmetastatic renal cell carcinoma have a worse chance of survival than those who do not, results of a large US study suggest.

Partial nephrectomy may offer younger renal cancer patients survival advantage Posted: 23 Feb 2014 04:00 PM PST Partial nephrectomy may offer younger patients with localized renal cancer a distinct survival advantage compared with the complete removal of the kidney, US research suggests.

Sedentary behaviour has unclear link with prostate cancer risk Posted: 23 Feb 2014 04:00 PM PST Sedentary behaviour is not a clearcut risk factor for prostate cancer, analysis of a large population-based cohort indicates.

Sedentary behaviour has unclear link with prostate cancer risk Posted: 23 Feb 2014 04:00 PM PST Sedentary behaviour is not a clearcut risk factor for prostate cancer, analysis of a large population-based cohort indicates.

Treatment targets beyond OA found for widespread pain onset Posted: 23 Feb 2014 04:00 PM PST Researchers have identified modifiable factors aside from osteoarthritis (OA) that are associated with the likelihood of older adults developing widespread pain.

Perioperative blood transfusion worsens kidney cancer patients’ survival Posted: 23 Feb 2014 04:00 PM PST Patients who receive blood transfusions around the time of their surgery for nonmetastatic renal cell carcinoma have a worse chance of survival than those who do not, results of a large US study suggest.

Partial nephrectomy may offer younger renal cancer patients survival advantage Posted: 23 Feb 2014 04:00 PM PST Partial nephrectomy may offer younger patients with localized renal cancer a distinct survival advantage compared with the complete removal of the kidney, US research suggests.

Detrusor muscle function declines with age Posted: 23 Feb 2014 04:00 PM PST Detrusor muscle function and efficiency decline with increasing age, a urodynamic study of women with stress urinary incontinence indicates.

Sedentary behaviour has unclear link with prostate cancer risk Posted: 23 Feb 2014 04:00 PM PST Sedentary behaviour is not a clearcut risk factor for prostate cancer, analysis of a large population-based cohort indicates.

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• Comorbid OCD and bipolar disorder should be treated as mood disorder
• Advanced age should not preclude sunitinib use for mRCC
• Altering sunitinib dosing schedule improves tolerability
• Factors predicting disengagement from psychosis early intervention identified
• Comorbid OCD and bipolar disorder should be treated as mood disorder
• Factors predicting disengagement from psychosis early intervention identified
• Advanced age should not preclude sunitinib use for mRCC
• Altering sunitinib dosing schedule improves tolerability

Comorbid OCD and bipolar disorder should be treated as mood disorder Posted: 20 Feb 2014 04:00 PM PST Most patients with both bipolar disorder and obsessive–compulsive disorder should be treated as having bipolar disorder, researchers suggest.

Advanced age should not preclude sunitinib use for mRCC Posted: 20 Feb 2014 04:00 PM PST Elderly kidney cancer patients benefit from sunitinib therapy just as much as their younger counterparts, a retrospective analysis of six clinical trials shows.

Altering sunitinib dosing schedule improves tolerability Posted: 20 Feb 2014 04:00 PM PST Shortening the time that patients with advanced renal cell carcinoma are on and off treatment with sunitinib improves the drug's overall tolerability without affecting its efficacy, say Japanese researchers.

Factors predicting disengagement from psychosis early intervention identified Posted: 20 Feb 2014 04:00 PM PST A study of first-episode psychosis patients in Hong Kong has found that those with fewer negative symptoms at presentation and poor medication compliance were more likely than others to disengage from an early intervention program.

Comorbid OCD and bipolar disorder should be treated as mood disorder Posted: 20 Feb 2014 04:00 PM PST Most patients with both bipolar disorder and obsessive–compulsive disorder should be treated as having bipolar disorder, researchers suggest.

Factors predicting disengagement from psychosis early intervention identified Posted: 20 Feb 2014 04:00 PM PST A study of first-episode psychosis patients in Hong Kong has found that those with fewer negative symptoms at presentation and poor medication compliance were more likely than others to disengage from an early intervention program.

Advanced age should not preclude sunitinib use for mRCC Posted: 20 Feb 2014 04:00 PM PST Elderly kidney cancer patients benefit from sunitinib therapy just as much as their younger counterparts, a retrospective analysis of six clinical trials shows.

Altering sunitinib dosing schedule improves tolerability Posted: 20 Feb 2014 04:00 PM PST Shortening the time that patients with advanced renal cell carcinoma are on and off treatment with sunitinib improves the drug's overall tolerability without affecting its efficacy, say Japanese researchers.

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• Support for progranulin role in bipolar disorder
• EGFR–TKI tumour response predicts NSCLC survival
• EGFR–TKI tumour response predicts NSCLC survival
• Support for progranulin role in bipolar disorder
• Psychotherapies have specific effects on psychosis symptoms
• Psychotherapies have specific effects on psychosis symptoms
• Nintedanib plus docetaxel shows second-line efficacy in recurrent NSCLC
• Nintedanib plus docetaxel shows second-line efficacy in recurrent NSCLC

Support for progranulin role in bipolar disorder Posted: 19 Feb 2014 04:00 PM PST Researchers have found reduced levels of plasma progranulin in patients with bipolar disorder, strengthening evidence for its possible role as a biomarker for the condition.

EGFR–TKI tumour response predicts NSCLC survival Posted: 19 Feb 2014 04:00 PM PST A partial or complete response to epidermal growth factor receptor tyrosine kinase inhibitor therapy is significantly associated with survival in patients with non-small-cell lung cancer, research suggests.

EGFR–TKI tumour response predicts NSCLC survival Posted: 19 Feb 2014 04:00 PM PST A partial or complete response to epidermal growth factor receptor tyrosine kinase inhibitor therapy is significantly associated with survival in patients with non-small-cell lung cancer, research suggests.

Support for progranulin role in bipolar disorder Posted: 19 Feb 2014 04:00 PM PST Researchers have found reduced levels of plasma progranulin in patients with bipolar disorder, strengthening evidence for its possible role as a biomarker for the condition.

Psychotherapies have specific effects on psychosis symptoms Posted: 19 Feb 2014 04:00 PM PST There are small but robust differences in the effects of different psychotherapies on psychosis symptoms, say the authors of a meta-analysis.

Psychotherapies have specific effects on psychosis symptoms Posted: 19 Feb 2014 04:00 PM PST There are small but robust differences in the effects of different psychotherapies on psychosis symptoms, say the authors of a meta-analysis.

Nintedanib plus docetaxel shows second-line efficacy in recurrent NSCLC Posted: 18 Feb 2014 04:00 PM PST Nintedanib plus docetaxel offers significant efficacy in patients with non-small-cell lung cancer who experience disease progression after first-line chemotherapy, phase III study results show.

Nintedanib plus docetaxel shows second-line efficacy in recurrent NSCLC Posted: 18 Feb 2014 04:00 PM PST Nintedanib plus docetaxel offers significant efficacy in patients with non-small-cell lung cancer who experience disease progression after first-line chemotherapy, phase III study results show.

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