Thursday, July 7, 2011

Medical News

Medical News

Novel FXIa inhibitor offers promising antithrombotic therapy

Posted: 07 Jul 2011 05:00 PM PDT

Preclinical research has shown that a small-molecule selective inhibitor of factor XIa is a promising antithrombotic therapy.

Factors predicting refractory bipolar outcomes identified

Posted: 07 Jul 2011 05:00 PM PDT

Patients with refractory bipolar disorder have better outcomes if they receive combined therapy, have fewer prior hospitalizations, and have better self-esteem, conclude Spanish researchers.

Outlook in gastric/GEJ cancer poor even with pathologic complete response

Posted: 07 Jul 2011 05:00 PM PDT

Patients with gastric or gastroesophageal junction adenocarcinoma face a significant risk for recurrence and mortality even if they achieve a pathologic complete response following neoadjuvant therapy and surgery, research shows.

Oral anticoagulant reduces blood loss during arthroplasty

Posted: 06 Jul 2011 05:00 PM PDT

Significantly less blood is lost after knee replacement when patients are treated with the oral anticoagulant dabigatran than with the low molecular weight heparin dalteparin, researchers say.

Better psychosocial functioning tools needed to assess schizophrenia patients

Posted: 06 Jul 2011 05:00 PM PDT

Validated tools that measure psychosocial functioning over time in schizophrenia are valuable for monitoring patients and evaluating pharmacological and non-pharmacological treatment strategies, argue UK and Portuguese clinicians.

Micro-RNA expression linked to cisplatin response in bladder cancer

Posted: 06 Jul 2011 05:00 PM PDT

Increasing expression of micro-RNA-34a increases sensitivity to chemotherapy in patients with muscle-invasive transitional cell carcinoma of the bladder, study findings have revealed.

Intraperitoneal fat linked to thoracic aorta thickening

Posted: 06 Jul 2011 05:00 PM PDT

Elevated intraperitoneal fat volume is associated with an increase in ascending aortic wall thickness in patients at high risk for cardiovascular events, a study finds.

Lp-PLA<sub>2</sub> not linked to endothelial dysfunction

Posted: 06 Jul 2011 05:00 PM PDT

Lipoprotein-associated phospholipase A2 mass and activity are not associated with endothelial dysfunction in patients without known cardiovascular disease or in patients with subclinical atherosclerosis, a US study has found.

Implantable exenatide provides injection-free alternative for Type 2 diabetes

Posted: 06 Jul 2011 05:00 PM PDT

Glycated hemoglobin levels and body weight can be reduced effectively in patients with Type 2 diabetes using an implantable device that allows continuous dosing with exenatide for 3 months, say researchers.

Risk for subclinical atherosclerosis high in youth with Type 1 diabetes

Posted: 06 Jul 2011 05:00 PM PDT

Young people with Type 1 diabetes have increased carotid intima-media thickness and greater arterial stiffness than their nondiabetic peers, show results from the SEARCH For Diabetes in Youth CVD study.

Aspirin dose affects ticagrelor ACS outcomes

Posted: 06 Jul 2011 05:00 PM PDT

The antiplatelet agent ticagrelor is better at preventing cardiovascular death, myocardial infarction, or stroke in patients with acute coronary syndrome when accompanied by a low rather than a high dose of aspirin, an analysis of the PLATO trial suggests.

NSAIDs linked to atrial fibrillation, flutter

Posted: 06 Jul 2011 05:00 PM PDT

Commonly prescribed non-steroidal anti-inflammatory drugs may increase the risk for atrial fibrillation or flutter, a case–control study suggests.

Cannabis use linked to earlier psychosis onset

Posted: 05 Jul 2011 05:00 PM PDT

Cannabis use is associated with an earlier onset of psychosis, conclude US and Australian scientists in findings that support the notion that cannabis has a causal association with the development of psychosis in some patients.
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