Medical News

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• Deep brain stimulation effective for bipolar and unipolar depression
• Predictors of QoL identified in Japanese inpatients with schizophrenia
• Airflow obstruction increases HF risk
• Family tree helps estimate mortality risk for inherited arrhythmia patients
• Weekly exenatide more effective than insulin glargine in long-term glycemic control
• Weight loss surgery ‘effective’ for treating diabetes in non-severely obese patients
• Weight loss surgery ‘effective’ for treating diabetes in non-severely obese patients
• Bathtub refinishers at risk for death from methylene chloride exposure
• Collaterals crucial determinant of endovascular stroke treatment outcomes
• Recurrent VTE risk reduced by immunosuppression in Behçet's disease patients

Deep brain stimulation effective for bipolar and unipolar depression Posted: 29 Feb 2012 04:00 PM PST Deep brain stimulation is an effective intervention for treatment-resistant depression in patients with either bipolar II disorder or major depressive disorder, say US researchers.

Predictors of QoL identified in Japanese inpatients with schizophrenia Posted: 29 Feb 2012 04:00 PM PST Results from a Japanese study show that increased negative symptoms, psychological discomfort, and resistance are significantly associated with reduced quality of life among inpatients with schizophrenia.

Airflow obstruction increases HF risk Posted: 28 Feb 2012 04:00 PM PST Reduced lung function and obstructive airway disease are strongly and independently associated with an increased risk for heart failure, US researchers report.

Family tree helps estimate mortality risk for inherited arrhythmia patients Posted: 28 Feb 2012 04:00 PM PST Dutch researchers have reconstructed family trees to estimate the mortality risk for individuals with inherited arrhythmia syndromes.

Weekly exenatide more effective than insulin glargine in long-term glycemic control Posted: 28 Feb 2012 04:00 PM PST Long-term treatment with exenatide once weekly provides significantly better glycemic control than once-daily insulin glargine in patients with poorly controlled diabetes, report Dutch researchers.

Weight loss surgery ‘effective’ for treating diabetes in non-severely obese patients Posted: 28 Feb 2012 04:00 PM PST Bariatric surgery is effective for treating non-severely obese Type 2 diabetes patients, say Chinese researchers who add that the metabolic benefits gained from the procedure can be sustained long after surgery.

Weight loss surgery ‘effective’ for treating diabetes in non-severely obese patients Posted: 28 Feb 2012 04:00 PM PST Bariatric surgery is effective for treating non-severely obese Type 2 diabetes patients, say Chinese researchers who add that the metabolic benefits gained from the procedure can be sustained long after surgery.

Bathtub refinishers at risk for death from methylene chloride exposure Posted: 28 Feb 2012 04:00 PM PST A report published by the Centers for Disease Control and Prevention in the USA highlights a significant risk for death associated with exposure to methylene chloride among people resurfacing or refinishing bathtubs.

Collaterals crucial determinant of endovascular stroke treatment outcomes Posted: 28 Feb 2012 04:00 PM PST Collateral blood flow trumps even time to treatment for predicting the outcomes of patients who undergo endovascular treatment for anterior circulation stroke, a large analysis suggests.

Recurrent VTE risk reduced by immunosuppression in Behçet's disease patients Posted: 28 Feb 2012 04:00 PM PST Research shows that immunosuppression treatment significantly reduces the risk for repeated episodes of venous thromboembolism in patients with Behçet's disease.

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Health Informatics News

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The Ava robot can take you to aisle 9 Posted: 29 Feb 2012 11:14 AM PST iRobot reorganizes and creates a business unit for its tablet-sporting Ava pedestal robot in retail, security, and healthcare. [Read more]

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Medical News

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• Limited end-of-life care options exist for Japanese cancer patients, say family members
• Eye movement test may help identify schizophrenia patient subgroup
• Allergy link to bipolar depression severity confirmed
• Increased urinary bisphenol A level linked to greater heart disease risk
• Body clock link to myocardial repolarization
• AF linked to increased cognitive, functional decline in the absence of stroke
• Complement complex predicts CV events in diabetes patients with myocardial infarction
• Goal setting improves outcome of diabetes education in low-income patients
• Increased apoB/A-I ratio independently associated with Type 2 diabetes
• Total cholesterol ‘reliable indicator’ of statin efficacy in diabetic patients
• Increased apoB/A-I ratio independently associated with Type 2 diabetes
• Total cholesterol ‘reliable indicator’ of statin efficacy in diabetic patients
• Airflow obstruction increases HF risk

Limited end-of-life care options exist for Japanese cancer patients, say family members Posted: 28 Feb 2012 04:00 PM PST A survey of bereaved family members suggests that the end-of-life options available to patients in Japan are limited.

Eye movement test may help identify schizophrenia patient subgroup Posted: 28 Feb 2012 04:00 PM PST The exploratory eye movement test may be effective for identifying a subgroup of patients with schizophrenia who have high levels of excitement/hostility, negative, and disorganization symptoms, say Japanese researchers.

Allergy link to bipolar depression severity confirmed Posted: 28 Feb 2012 04:00 PM PST Scientists have demonstrated that a complex relationship exists between bipolar I disorder and allergic disease, which results in worsening symptoms of depression.

Increased urinary bisphenol A level linked to greater heart disease risk Posted: 27 Feb 2012 04:00 PM PST Individuals with increased levels of urinary bisphenol A are at an elevated risk for coronary artery disease later in life, UK researchers say.

Body clock link to myocardial repolarization Posted: 27 Feb 2012 04:00 PM PST Myocardial repolarization in mice is partly controlled by a transcription factor that is regulated by the circadian clock, shows research.

AF linked to increased cognitive, functional decline in the absence of stroke Posted: 27 Feb 2012 04:00 PM PST Patients with atrial fibrillation have an increased risk for cognitive and functional decline, even when they have not experienced stroke, a study suggests.

Complement complex predicts CV events in diabetes patients with myocardial infarction Posted: 27 Feb 2012 04:00 PM PST High hospital admission levels of sC5b-9, the soluble form of the membrane attack complex, are associated with future cardiovascular events in patients with Type 2 diabetes with myocardial infarction, report researchers.

Goal setting improves outcome of diabetes education in low-income patients Posted: 27 Feb 2012 04:00 PM PST The incorporation of goal setting into diabetes education has a beneficial impact on glycemic control among low-income patients, show study findings.

Increased apoB/A-I ratio independently associated with Type 2 diabetes Posted: 27 Feb 2012 04:00 PM PST An elevated apolipoprotein B/A-I ratio is associated with Type 2 diabetes independent of other risk factors for the condition and conventional lipid parameters, show results of a study published in Diabetic Medicine.

Total cholesterol ‘reliable indicator’ of statin efficacy in diabetic patients Posted: 27 Feb 2012 04:00 PM PST UK researchers say that total cholesterol changes can be used as a measure of statin efficacy in the absence of low-density lipoprotein cholesterol measurements in diabetic patients.

Increased apoB/A-I ratio independently associated with Type 2 diabetes Posted: 27 Feb 2012 04:00 PM PST An elevated apolipoprotein B/A-I ratio is associated with Type 2 diabetes independent of other risk factors for the condition and conventional lipid parameters, show results of a study published in Diabetic Medicine.

Total cholesterol ‘reliable indicator’ of statin efficacy in diabetic patients Posted: 27 Feb 2012 04:00 PM PST UK researchers say that total cholesterol changes can be used as a measure of statin efficacy in the absence of low-density lipoprotein cholesterol measurements in diabetic patients.

Airflow obstruction increases HF risk Posted: 27 Feb 2012 04:00 PM PST Reduced lung function and obstructive airway disease are strongly and independently associated with an increased risk for heart failure, US researchers report.

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Medical News

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• Smoking not linked to illness course in bipolar disorder patients
• Memory-related neural activation linked to outcomes in schizophrenia
• Toll-like receptor activity increased in metabolic syndrome patients

Smoking not linked to illness course in bipolar disorder patients Posted: 27 Feb 2012 04:00 PM PST Smoking is not associated with a worsened illness course in patients with bipolar disorder, although it is linked to an increased risk for alcohol and cannabis use disorders among adolescents with the mood condition, say US researchers.

Memory-related neural activation linked to outcomes in schizophrenia Posted: 27 Feb 2012 04:00 PM PST Patients with first-episode schizophrenia who later achieve remission differ from those who do not regarding neural activation patterns in response to a memory task, study results show.

Toll-like receptor activity increased in metabolic syndrome patients Posted: 26 Feb 2012 04:00 PM PST The expression and activity of toll-like receptor 2 and 4 are increased in the monocytes of patients with the metabolic syndrome and could contribute to the increased risk for diabetes and cardiovascular disease in this population, report US researchers.

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Medical News

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• Specialty hospitals perform more ‘unclear’ PCIs but with better outcomes
• Brain natriuretic peptide linked to acute kidney injury after cardiac surgery
• CVD risk varies markedly, may be underestimated in hypertension patients
• LpPLA₂ activity, not mass, predicts increased CVD risk
• CT colonography ‘perfectly viable’ CRC screening tool for over 65s
• CVD risk varies markedly, may be underestimated in hypertension patients
• LpPLA₂ activity, not mass, predicts increased CVD risk
• Endometriosis linked to three subtypes of ovarian cancer
• CT colonography ‘perfectly viable’ CRC screening tool for over 65s
• CBT improves hot flashes in breast cancer survivors
• Apixaban effective in AF patients with previous stroke
• Large inter-site variation in anticoagulation therapy targets
• Adipokine levels increased in overweight bipolar disorder patients
• Combined use of recommended HF therapy enhances survival
• MRSA infection highly prevalent in pediatric open airway surgery
• Decreased GSH levels predict brain volume loss in children with psychosis
• Depressive symptoms linked to CVD risk in bipolar disorder patients
• Intravenous iron improves life quality in iron-deficient heart failure patients
• Newly identified oral bacterium linked to serious disease
• Bone mass reduced in older schizophrenia patients
• Hypertensive pregnancies linked to mental health disorder risk in offspring
• Anxiety linked to increased impulsivity in mood disorder patients
• Early DTP vaccination increases mortality in infant girls
• Hypertensive pregnancies linked to mental health disorder risk in offspring
• Mood state influences odor detection in bipolar disorder patients
• EMA issues aliskiren warning
• External cooling improves early outcomes in septic shock
• Childhood trauma linked to reduced cognition, amygdala volume in FEP

Specialty hospitals perform more ‘unclear’ PCIs but with better outcomes Posted: 26 Feb 2012 04:00 PM PST Specialty hospitals perform a higher number of percutaneous coronary intervention procedures for unclear indications than other hospitals, but are associated with lower rates of adverse outcomes afterwards, two analyses of a large US registry show.

Brain natriuretic peptide linked to acute kidney injury after cardiac surgery Posted: 26 Feb 2012 04:00 PM PST Elevated pre-operative brain natriuretic peptide levels are associated with an increased risk for post-operative acute kidney injury in high-risk patients undergoing cardiac surgery, a study suggests.

CVD risk varies markedly, may be underestimated in hypertension patients Posted: 26 Feb 2012 04:00 PM PST There is a wide variation in cardiovascular disease risk among hypertension patients and it may be underestimated by use of current risk models, with those patients at high risk receiving suboptimal treatment, a study suggests.

LpPLA<sub>2</sub> activity, not mass, predicts increased CVD risk Posted: 26 Feb 2012 04:00 PM PST Results of a case-control study support the use of lipoprotein-associated phospholipase A2 activity, instead of mass, to identify individuals with increased cardiometabolic risk.

CT colonography ‘perfectly viable’ CRC screening tool for over 65s Posted: 26 Feb 2012 04:00 PM PST Computed tomographic colonography is an effective method of colorectal cancer screening for patients aged 65 years and older, US researchers confirm.

CVD risk varies markedly, may be underestimated in hypertension patients Posted: 26 Feb 2012 04:00 PM PST There is a wide variation in cardiovascular disease risk among hypertension patients and it may be underestimated by use of current risk models, with those patients at high risk receiving suboptimal treatment, a study suggests.

LpPLA<sub>2</sub> activity, not mass, predicts increased CVD risk Posted: 26 Feb 2012 04:00 PM PST Results of a case-control study support the use of lipoprotein-associated phospholipase A2 activity, instead of mass, to identify individuals with increased cardiometabolic risk.

Endometriosis linked to three subtypes of ovarian cancer Posted: 26 Feb 2012 04:00 PM PST Women with a history of endometriosis are at a significantly increased risk for three types of ovarian cancer, according to a study in TheLancet.

CT colonography ‘perfectly viable’ CRC screening tool for over 65s Posted: 26 Feb 2012 04:00 PM PST Computed tomographic colonography is an effective method of colorectal cancer screening for patients aged 65 years and older, US researchers confirm.

CBT improves hot flashes in breast cancer survivors Posted: 26 Feb 2012 04:00 PM PST Breast cancer survivors who suffer hot flashes and night sweats may benefit from treatment with cognitive behavioral therapy, results of a randomized controlled trial show.

Apixaban effective in AF patients with previous stroke Posted: 26 Feb 2012 04:00 PM PST The stroke preventive benefits of apixaban versus aspirin in patients with atrial fibrillation and contraindications to warfarin are evident in those with a previous stroke or transient ischemic attack, say the AVERROES investigators.

Large inter-site variation in anticoagulation therapy targets Posted: 26 Feb 2012 04:00 PM PST A study of veterans taking warfarin has found a large variation in international normalized ratio between different institutions.

Adipokine levels increased in overweight bipolar disorder patients Posted: 23 Feb 2012 04:00 PM PST Overweight patients with bipolar disorder exhibit higher levels of certain adipokines and inflammatory markers than overweight mentally healthy individuals, research shows.

Combined use of recommended HF therapy enhances survival Posted: 23 Feb 2012 04:00 PM PST A study has found that using a combination of several key guideline-recommended therapies for heart failure treatment improves 2-year survival by 90%.

MRSA infection highly prevalent in pediatric open airway surgery Posted: 23 Feb 2012 04:00 PM PST Children undergoing open-neck airway surgery should be routinely screened for methicillin-resistant Staphylococcus aureus infection, US researchers recommend.

Decreased GSH levels predict brain volume loss in children with psychosis Posted: 23 Feb 2012 04:00 PM PST Results from a Spanish study suggest that decreased glutathione levels predict brain volume reductions over 2 years in children and adolescents with first-episode psychosis.

Depressive symptoms linked to CVD risk in bipolar disorder patients Posted: 22 Feb 2012 04:00 PM PST Depression, but not mania, is significantly associated with an elevated 10-year risk for cardiovascular disease in patients with bipolar disorder, research shows.

Intravenous iron improves life quality in iron-deficient heart failure patients Posted: 22 Feb 2012 04:00 PM PST Health-related quality of life in iron-deficient heart failure patients is significantly improved with intravenous ferric carboxymaltose treatment, research suggests.

Newly identified oral bacterium linked to serious disease Posted: 22 Feb 2012 04:00 PM PST A newly discovered bacterium that lives in the mouth has been linked to serious infectious diseases affecting the heart and brain, research shows.

Bone mass reduced in older schizophrenia patients Posted: 22 Feb 2012 04:00 PM PST Results from a Japanese study show that older patients with schizophrenia have significantly reduced bone mass compared with the older general population.

Hypertensive pregnancies linked to mental health disorder risk in offspring Posted: 21 Feb 2012 04:00 PM PST Individuals born to women who experienced hypertension without proteinuria during pregnancy are at increased risk for mental health disorders, results from a Finnish study suggest.

Anxiety linked to increased impulsivity in mood disorder patients Posted: 21 Feb 2012 04:00 PM PST The presence of anxiety is associated with increased impulsivity in patients with bipolar disorder or major depressive disorder, research shows.

Early DTP vaccination increases mortality in infant girls Posted: 21 Feb 2012 04:00 PM PST Girls who receive diphtheria-tetanus-pertussis vaccination at 2 months of age have a higher mortality risk compared with boys, despite good nutritional status, researchers have discovered.

Hypertensive pregnancies linked to mental health disorder risk in offspring Posted: 21 Feb 2012 04:00 PM PST Individuals born to women who experienced hypertension without proteinuria during pregnancy are at increased risk for mental health disorders, results from a Finnish study suggest.

Mood state influences odor detection in bipolar disorder patients Posted: 20 Feb 2012 04:00 PM PST Odor-detection sensitivity is differentially associated with mania and depression in patients with bipolar disorder, results from a US study show.

EMA issues aliskiren warning Posted: 20 Feb 2012 04:00 PM PST The European Medicines Agency has announced that a combination of aliskiren with ACE inhibitors or angiotensin-receptor inhibitors is no longer recommended.

External cooling improves early outcomes in septic shock Posted: 20 Feb 2012 04:00 PM PST External cooling of patients with fever and septic shock reduces their vasopressor requirements and risk for early mortality, shows a randomized trial, but the effect on long-term outcomes remains unclear.

Childhood trauma linked to reduced cognition, amygdala volume in FEP Posted: 20 Feb 2012 04:00 PM PST A history of childhood trauma is associated with reduced cognitive performance and amygdala volume in patients with first-episode psychosis, UK research suggests.

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