Medical News

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• HbA1c diagnostic threshold set for Middle-Eastern population
• FDA warns fenofibric acid may not lower heart attack, stroke risk
• <i>APOE</i> genotype determines influence of smoking on heart disease risk
• Affective and nonaffective FEP patients show brain volume abnormalities
• Integrated psychological intervention benefits patients at risk for psychosis
• TRA·CER: Vorapaxar fails to meet primary endpoint, increases bleeding risk
• Urinary angiotensinogen predicts renal, CV outcomes in diabetes
• Elevated micronuclei frequency linked to increased HbA1c in diabetes
• Adiponectin levels may predict presence of overt HF in CAD
• Eating wholegrains in adolescence may reduce chronic disease risk
• High CHADS₂ also predicts bleeding, mortality
• Apixaban no more effective than enoxaparin in preventing VTE
• VerifyNow P2Y12 assay influenced by <i>CYP2C9</i> variants
• High CHADS₂ also predicts bleeding, mortality

HbA1c diagnostic threshold set for Middle-Eastern population Posted: 15 Nov 2011 04:00 PM PST Glycated hemoglobin is a suitable test for the diagnosis of diabetes in the Abu Dhabi population, show study findings.

FDA warns fenofibric acid may not lower heart attack, stroke risk Posted: 15 Nov 2011 04:00 PM PST The US Food and Drug Administration has announced that the cholesterol-lowering agent fenofibric acid may not lower a patient's risk for experiencing a heart attack or stroke.

<i>APOE</i> genotype determines influence of smoking on heart disease risk Posted: 15 Nov 2011 04:00 PM PST Individuals who carry the E2 isoform protein allele for the apolipoprotein E gene have a lower risk for coronary heart disease than those who are homozygous for the ε3 allele, while male ε4 carriers have no increased CHD risk, analysis shows.

Affective and nonaffective FEP patients show brain volume abnormalities Posted: 15 Nov 2011 04:00 PM PST Patients with affective or nonaffective first-episode psychosis show grey matter volume abnormalities compared with mentally healthy individuals, say researchers.

Integrated psychological intervention benefits patients at risk for psychosis Posted: 15 Nov 2011 04:00 PM PST An integrated psychological intervention may help delay or prevent the onset of psychosis among patients in an early initial prodromal state, research suggests.

TRA·CER: Vorapaxar fails to meet primary endpoint, increases bleeding risk Posted: 14 Nov 2011 04:00 PM PST The oral protease-activated-receptor 1 antagonist, vorapaxar, does not significantly reduce the risk for cardiovascular disease or death when added to standard therapy compared with standard therapy alone in patients with acute coronary syndrome, show results from the TRA·CER study.

Urinary angiotensinogen predicts renal, CV outcomes in diabetes Posted: 14 Nov 2011 04:00 PM PST Urinary angiotensinogen levels correlate with decline in renal function and incidence of adverse renal and cardiovascular outcomes in patients with Type 2 diabetes, study findings show.

Elevated micronuclei frequency linked to increased HbA1c in diabetes Posted: 14 Nov 2011 04:00 PM PST Increased glycosylation in Type 2 diabetes seems to induce oxidative damage in DNA resulting in increased micronuclei frequency, report researchers.

Adiponectin levels may predict presence of overt HF in CAD Posted: 14 Nov 2011 04:00 PM PST Levels of the cytokine adiponectin are higher among patients with cardiac ischemia and overt heart failure than in ischemic patients with left ventricular dysfunction or normal systolic function, study findings suggest.

Eating wholegrains in adolescence may reduce chronic disease risk Posted: 14 Nov 2011 04:00 PM PST Few US adolescents eat the nationally recommended amount of wholegrain, but those who do may have a reduced risk for developing chronic diseases, such as diabetes, US study results indicate.

High CHADS<sub>2</sub> also predicts bleeding, mortality Posted: 14 Nov 2011 04:00 PM PST The CHADS2 score predicts the risk for bleeding, intracranial bleeding, and mortality, as well as stroke, in patients with atrial fibrillation, shows an analysis of the RE-LY trial.

Apixaban no more effective than enoxaparin in preventing VTE Posted: 14 Nov 2011 04:00 PM PST An extended course of thromboprophylaxis with apixaban is no more effective in preventing venous thromboembolism in medically ill patients than a shorter course of enoxaparin, suggest the results of the ADOPT trial.

VerifyNow P2Y12 assay influenced by <i>CYP2C9</i> variants Posted: 14 Nov 2011 04:00 PM PST Loss-of-function variants in cytochrome P450 2C9 are associated with decreased clopidogrel-mediated platelet inhibition and an increased rate of high on-treatment residual platelet reactivity by the VerifyNow P2Y12 assay, Austrian researchers report.

High CHADS<sub>2</sub> also predicts bleeding, mortality Posted: 14 Nov 2011 04:00 PM PST The CHADS2 score predicts the risk for bleeding, intracranial bleeding, and mortality, as well as stroke, in patients with atrial fibrillation, shows an analysis of the RE-LY trial.

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