Medical News

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• Mammographic density 'unrelated to breast cancer death risk'
• TNF inhibitors best cardiac option for psoriasis patients
• Sleep apnea’s contribution to diabetic nephropathy needs attention
• Excessive daytime sleepiness during pregnancy should raise the alarm
• Mammographic density 'unrelated to breast cancer death risk'
• TNF inhibitors best cardiac option for psoriasis patients
• Sleep apnea’s contribution to diabetic nephropathy needs attention
• Excessive daytime sleepiness during pregnancy should raise the alarm
• Quitting could cut SAH risk for some smokers

Mammographic density 'unrelated to breast cancer death risk' Posted: 30 Aug 2012 05:00 PM PDT Although high-density breast cancer high breast density on mammography is an established risk factor for developing breast cancer, it is not associated with an increased risk for death, say US investigators who suggest different factors may affect risk at different times.

TNF inhibitors best cardiac option for psoriasis patients Posted: 30 Aug 2012 05:00 PM PDT Use of tumor necrosis factor inhibitors is associated with a significantly reduced risk for myocardial infarction in psoriasis patients compared with use of other medications, report researchers.

Sleep apnea’s contribution to diabetic nephropathy needs attention Posted: 30 Aug 2012 05:00 PM PDT The effect of obstructive sleep apnea syndrome on the development of diabetic nephropathy requires investigation, say researchers.

Excessive daytime sleepiness during pregnancy should raise the alarm Posted: 30 Aug 2012 05:00 PM PDT Excessive daytime sleepiness is a common occurrence in pregnant women, particularly during the third trimester, but researchers warn that it might not always be physiologically normal.

Mammographic density 'unrelated to breast cancer death risk' Posted: 30 Aug 2012 05:00 PM PDT Although high-density breast cancer high breast density on mammography is an established risk factor for developing breast cancer, it is not associated with an increased risk for death, say US investigators who suggest different factors may affect risk at different times.

TNF inhibitors best cardiac option for psoriasis patients Posted: 30 Aug 2012 05:00 PM PDT Use of tumor necrosis factor inhibitors is associated with a significantly reduced risk for myocardial infarction in psoriasis patients compared with use of other medications, report researchers.

Sleep apnea’s contribution to diabetic nephropathy needs attention Posted: 30 Aug 2012 05:00 PM PDT The effect of obstructive sleep apnea syndrome on the development of diabetic nephropathy requires investigation, say researchers.

Excessive daytime sleepiness during pregnancy should raise the alarm Posted: 30 Aug 2012 05:00 PM PDT Excessive daytime sleepiness is a common occurrence in pregnant women, particularly during the third trimester, but researchers warn that it might not always be physiologically normal.

Quitting could cut SAH risk for some smokers Posted: 30 Aug 2012 05:00 PM PDT Stopping smoking may help to attenuate people's risk for subarachnoid hemorrhage, say researchers.

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Medical News

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• Subsyndromal symptoms hasten relapse in BD
• Smoking rates increased in relatives of schizophrenia patients
• Physical, verbal reminders could improve preoperative preparation
• Dabigatran exposure may RE-LY on genetics
• Early European TAVI registry data unveiled
• Anastomotic leakage does not increase rectal cancer recurrence risk
• Emergency readmission after endoscopy linked to mortality risk
• Anastomotic leakage does not increase rectal cancer recurrence risk
• Sterotactic radiotherapy offers good results in recurrent head and neck cancer
• Oral lesion progression markers validated, discovered

Subsyndromal symptoms hasten relapse in BD Posted: 30 Aug 2012 05:00 PM PDT The presence of subsyndromal affective symptoms is associated with a significantly shorter time to relapse among euthymic patients with bipolar disorder, Spanish research shows.

Smoking rates increased in relatives of schizophrenia patients Posted: 30 Aug 2012 05:00 PM PDT The unaffected first-degree relatives of patients with schizophrenia are more likely to be smokers than individuals without a family history of the disorder, researchers report.

Physical, verbal reminders could improve preoperative preparation Posted: 29 Aug 2012 05:00 PM PDT Patients may be unable to recall much of the preoperative information they are given by anesthesiologists, suggesting the need for reminders such as printed instructions, and telephone calls the night before their procedure is scheduled, says a US research team.

Dabigatran exposure may RE-LY on genetics Posted: 29 Aug 2012 05:00 PM PDT Researchers have found that variants in the ABCB1 and CES1 genes are associated with increased dabigatran plasma levels in patients taking the oral anticoagulant.

Early European TAVI registry data unveiled Posted: 29 Aug 2012 05:00 PM PDT The 1-month follow-up results of the Transcatheter Valve Treatment Sentinel Pilot Registry have provided data on factors associated with transcatheter aortic valve implantation, as well as short term outcomes, in Europe.

Anastomotic leakage does not increase rectal cancer recurrence risk Posted: 29 Aug 2012 05:00 PM PDT Incidence of clinical anastomotic leak after anterior resection for patients with rectal adenocarcinoma does not increase the risk for local disease recurrence, despite previous studies indicating the opposite, report US researchers.

Emergency readmission after endoscopy linked to mortality risk Posted: 29 Aug 2012 05:00 PM PDT The risk for mortality is significantly increased among patients who are readmitted urgently following endoscopy, compared with other endoscopy patients, a UK study shows.

Anastomotic leakage does not increase rectal cancer recurrence risk Posted: 29 Aug 2012 05:00 PM PDT Incidence of clinical anastomotic leak after anterior resection for patients with rectal adenocarcinoma does not increase the risk for local disease recurrence, despite previous studies indicating the opposite, report US researchers.

Sterotactic radiotherapy offers good results in recurrent head and neck cancer Posted: 29 Aug 2012 05:00 PM PDT For patients with recurring head and neck cancer, stereotactic body radiotherapy offers a feasible and tolerable salvage treatment, with median overall survival rates of more than 1 year, report researchers.

Oral lesion progression markers validated, discovered Posted: 29 Aug 2012 05:00 PM PDT Loss of heterozygosity can reliably differentiate between individuals with premalignant oral lesions who are likely to progress to oral carcinoma, and those who are not, show study results.

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Medical News

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• Early treatment dropout common in bipolar disorder
• Patients at risk for psychosis report increased childhood trauma
• Neuromuscular block may not hamper facemask airway success
• FAST-MI highlights young women at risk for heart disease
• Tunes and T-shirts for cardiac rehabilitation
• Long-term cardiac impact of Japan quake revealed
• Endoscopic microsurgery effective for giant rectal adenomas
• Country drinking water may pose child health risk
• Evidence lacking for use of misoprostol in PPH prevention
• Endoscopic microsurgery effective for giant rectal adenomas
• Where there’s no smoke, there’s less bladder cancer
• Childhood coagulation marker levels distinct from adulthood

Early treatment dropout common in bipolar disorder Posted: 29 Aug 2012 05:00 PM PDT Results from a South Korean study show that around one-third of patients with bipolar disorder discontinue psychiatric treatment within 12 months of initiation.

Patients at risk for psychosis report increased childhood trauma Posted: 29 Aug 2012 05:00 PM PDT Patients at clinical high risk for psychosis are more likely to have a history of traumatic childhood experiences than mentally healthy individuals, Finnish researchers report.

Neuromuscular block may not hamper facemask airway success Posted: 28 Aug 2012 05:00 PM PDT It may not be necessary to wait to establish good facemask ventilation before administering neuromuscular block, a study suggests.

FAST-MI highlights young women at risk for heart disease Posted: 28 Aug 2012 05:00 PM PDT An analysis of four French registries has shown a dramatic drop in ST-segment-elevation myocardial infarction mortality from 1995 to 2010, accompanied by a significant change in patient characteristics.

Tunes and T-shirts for cardiac rehabilitation Posted: 28 Aug 2012 05:00 PM PDT Two studies presented at the European Society of Cardiology Congress in Munich, Germany, showed how researchers are developing innovative approaches to help patients get the most out of cardiac rehabilitation.

Long-term cardiac impact of Japan quake revealed Posted: 28 Aug 2012 05:00 PM PDT The earthquake and tsunami that devastated parts of eastern Japan in 2011 led to a significantly increased weekly occurrence of cardiovascular disease in the months after the event, study findings show.

Endoscopic microsurgery effective for giant rectal adenomas Posted: 28 Aug 2012 05:00 PM PDT Transanal endoscopic microsurgery on large rectal adenomas provides results comparable to or better than those reported for alternative techniques, shows a UK study.

Country drinking water may pose child health risk Posted: 28 Aug 2012 05:00 PM PDT Findings from a UK study published in PLoS ONE suggest that small private drinking water supplies, typically found in countryside locations, are more likely to be contaminated and result in gastrointestinal illness in children than standard mains water supplies.

Evidence lacking for use of misoprostol in PPH prevention Posted: 28 Aug 2012 05:00 PM PDT There is insufficient evidence for the effectiveness of misoprostol in preventing postpartum hemorrhage, suggest findings from a review of available research published in the Journal of the Royal Society of Medicine.

Endoscopic microsurgery effective for giant rectal adenomas Posted: 28 Aug 2012 05:00 PM PDT Transanal endoscopic microsurgery on large rectal adenomas provides results comparable to or better than those reported for alternative techniques, shows a UK study.

Where there’s no smoke, there’s less bladder cancer Posted: 28 Aug 2012 05:00 PM PDT Giving up smoking can significantly improve clinical outcomes in patients with urothelial carcinoma of the bladder, report US researchers.

Childhood coagulation marker levels distinct from adulthood Posted: 28 Aug 2012 05:00 PM PDT Levels of key coagulation markers significantly vary with age in children, research reveals, potentially affecting the diagnosis and treatment of pediatric thrombotic and hemorrhagic disease.

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• Mortality risk similar for White vs Black diabetics
• Factors linked to occupational disability in BD identified
• DUP may differentiate schizoaffective disorder from BD
• LCZ696 findings of PARAMOUNT importance
• Non-invasive fractional flow reserve still out of reach
• PROTECT: Still no clear winner in the battle of the stent generations
• Obese adolescents have high incidence gallstones
• Gold-standard antibiotic suboptimal for end-stage renal disease
• Obese adolescents have high incidence gallstones
• Model predicts lung cancer risk
• Reduced synaptic-function explains neuronal atrophy in major depressive disorder
• Informed consent process lacks information about adverse events, treatment alternatives
• Knocking some sense into cystic fibrosis assessment
• Model predicts lung cancer risk
• TREVO 2 adds momentum to mechanical intervention for stroke

Mortality risk similar for White vs Black diabetics Posted: 28 Aug 2012 05:00 PM PDT Diabetes does not lead to an intrinsically poorer survival in African Americans than it does in White Americans, report US researchers.

Factors linked to occupational disability in BD identified Posted: 28 Aug 2012 05:00 PM PDT Occupational disability in patients with bipolar disorder is associated with the presence of axis II disorders, a greater number of previous manic episodes, older age, and not being in a stable relationship, researchers report.

DUP may differentiate schizoaffective disorder from BD Posted: 28 Aug 2012 05:00 PM PDT Among individuals with a first episode of psychotic mania (FEPM), a longer duration of untreated psychosis may differentiate patients with schizoaffective disorder from those with bipolar I disorder, study results suggest.

LCZ696 findings of PARAMOUNT importance Posted: 27 Aug 2012 05:00 PM PDT A phase II trial of the first-in-class angiotensin receptor neprilysin inhibitor, LCZ696, has shown that the compound may improve treatment of heart failure patients.

Non-invasive fractional flow reserve still out of reach Posted: 27 Aug 2012 05:00 PM PDT A novel, non-invasive approach to determining fractional flow reserve failed to show sufficient diagnostic accuracy to meet the primary endpoint of the DeFACTO trial, but was more accurate for diagnosing coronary artery ischemia than computed tomography, reported the trial's lead investigator.

PROTECT: Still no clear winner in the battle of the stent generations Posted: 27 Aug 2012 05:00 PM PDT Three-year rates of stent thrombosis with zotarolimus- and sirolimus-eluting stents are low and comparable, show results of the PROTECT trial.

Obese adolescents have high incidence gallstones Posted: 27 Aug 2012 05:00 PM PDT The recent rise in childhood obesity has led to a dramatic increase in the number of older children and adolescents with gallstones, say researchers.

Gold-standard antibiotic suboptimal for end-stage renal disease Posted: 27 Aug 2012 05:00 PM PDT Only one-fifth of patients with end-stage renal disease and methicillin-susceptible Staphylococcus aureus bacteremia are treated with cefazolin, research suggests.

Obese adolescents have high incidence gallstones Posted: 27 Aug 2012 05:00 PM PDT The recent rise in childhood obesity has led to a dramatic increase in the number of older children and adolescents with gallstones, say researchers.

Model predicts lung cancer risk Posted: 27 Aug 2012 05:00 PM PDT Researchers have shown that The Liverpool Lung Project Risk Model is effective in identifying those at the highest risk for lung cancer within 5 years, and who are therefore suitable for computed tomography screening.

Reduced synaptic-function explains neuronal atrophy in major depressive disorder Posted: 27 Aug 2012 05:00 PM PDT Patients with major depressive disorder have lower expression of synaptic-function-related genes in the dorsolateral prefrontal cortex than their counterparts without the condition, indicate findings from a gene profiling study.

Informed consent process lacks information about adverse events, treatment alternatives Posted: 27 Aug 2012 05:00 PM PDT There is a lack of information about adverse events and treatment options during the informed consent process, show the results of a video simulation-based study of patients with schizophrenia, family members of patients with schizophrenia, and healthcare providers.

Knocking some sense into cystic fibrosis assessment Posted: 27 Aug 2012 05:00 PM PDT A deficient sense of smell is significantly more common among individuals with cystic fibrosis than it is in healthy people, report researchers.

Model predicts lung cancer risk Posted: 27 Aug 2012 05:00 PM PDT Researchers have shown that The Liverpool Lung Project Risk Model is effective in identifying those at the highest risk for lung cancer within 5 years, and who are therefore suitable for computed tomography screening.

TREVO 2 adds momentum to mechanical intervention for stroke Posted: 27 Aug 2012 05:00 PM PDT Patients with large vessel occlusion stroke are more likely to achieve reperfusion if treated with the Trevo retriever than with the Merci retriever, say the TREVO 2 investigators.

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