Medical News

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• Fibrinogen and FXIII activity correlate with bleeding after cardiac surgery
• VITATOPS dampens hopes of stroke prevention with B vitamins
• Psoriasis patients need better education to self-manage effectively
• Four-kallikrein PSA panel predicts likelihood of prostate cancer after negative biopsy
• Careful patient selection improves prostate salvage brachytherapy outcomes
• No benefit from infusional chemotherapy in early breast cancer
• Four-kallikrein PSA panel predicts likelihood of prostate cancer after negative biopsy
• Careful patient selection improves prostate salvage brachytherapy outcomes
• Cholesterol crystal-inflammation link confirmed in human cells
• Low HDL cholesterol predicts culprit plaque rupture in ACS
• All metabolic syndrome definitions predict future diabetes and CVD
• Diets high in GI and carbohydrate, low in fiber increase Type 2 diabetes risk
• Low cardiac function may accelerate brain aging
• <i>CYP2C19</i> variant predicts poor clopidogrel response in PCI patients
• No benefit from infusional chemotherapy in early breast cancer
• CRASH-2: Tranexamic acid cuts mortality in trauma patients
• ‘Rapid sequence spinal’ avoids general anesthesia in category-1 sections
• Functional recovery best after femoral nerve block for knee arthroplasty
• Casopitant enhances ondansetron effect on PONV risk

Fibrinogen and FXIII activity correlate with bleeding after cardiac surgery Posted: 05 Aug 2010 05:00 PM PDT Plasma levels of fibrinogen and coagulation factor XIII activity correlate inversely with postoperative blood loss in patients undergoing coronary artery bypass graft surgery, a Swedish study has found.

VITATOPS dampens hopes of stroke prevention with B vitamins Posted: 05 Aug 2010 05:00 PM PDT The VITATOPS trial, conducted in patients with previous stroke or transient ischemic attack , has been unable to demonstrate the putative vascular benefits of B-vitamin treatment.

Psoriasis patients need better education to self-manage effectively Posted: 05 Aug 2010 05:00 PM PDT More systematic educational interventions are needed for patients with mild-to-moderate psoriasis in order for them to effectively self-manage their condition, UK research suggests.

Four-kallikrein PSA panel predicts likelihood of prostate cancer after negative biopsy Posted: 05 Aug 2010 05:00 PM PDT Research results suggest that adding a panel of four kallikrein markers to a prostate cancer prediction model could greatly reduce the number of unnecessary biopsies undertaken in men with elevated prostate-specific antigen levels after a previously negative biopsy.

Careful patient selection improves prostate salvage brachytherapy outcomes Posted: 05 Aug 2010 05:00 PM PDT Salvage brachytherapy for failed initial prostate radiation is most beneficial in terms of oncologic and quality-of-life outcomes in patients with low pre-salvage prostate-specific antigen levels, and no previous pelvic lymph node dissection, say researchers.

No benefit from infusional chemotherapy in early breast cancer Posted: 05 Aug 2010 05:00 PM PDT For patients with early-stage breast cancer, adjuvant treatment with intravenous epirubicin, cisplatin, and 5-fluorouracil shows no benefit in terms of reducing relapse rates over 5-FU, epirubicin, and cyclophosphamide, study results show.

Four-kallikrein PSA panel predicts likelihood of prostate cancer after negative biopsy Posted: 05 Aug 2010 05:00 PM PDT Research results suggest that adding a panel of four kallikrein markers to a prostate cancer prediction model could greatly reduce the number of unnecessary biopsies undertaken in men with elevated prostate-specific antigen levels after a previously negative biopsy.

Careful patient selection improves prostate salvage brachytherapy outcomes Posted: 05 Aug 2010 05:00 PM PDT Salvage brachytherapy for failed initial prostate radiation is most beneficial in terms of oncologic and quality-of-life outcomes in patients with low pre-salvage prostate-specific antigen levels, and no previous pelvic lymph node dissection, say researchers.

Cholesterol crystal-inflammation link confirmed in human cells Posted: 05 Aug 2010 05:00 PM PDT Cholesterol crystals are able to induce the release of inflammatory molecules from human macrophages, report Finnish researchers.

Low HDL cholesterol predicts culprit plaque rupture in ACS Posted: 05 Aug 2010 05:00 PM PDT Low levels of high-density lipoprotein cholesterol and abdominal obesity are risk factors for culprit plaque rupture in patients with acute coronary syndromes, a Japanese team has shown.

All metabolic syndrome definitions predict future diabetes and CVD Posted: 05 Aug 2010 05:00 PM PDT A Finnish study reports that the metabolic syndrome, irrespective of the definition used, is a significant predictor for diabetes and cardiovascular disease.

Diets high in GI and carbohydrate, low in fiber increase Type 2 diabetes risk Posted: 05 Aug 2010 05:00 PM PDT Study results show that consumption of a diet with a high glycemic load and index that is high in starch and low in fiber increases the risk for developing Type 2 diabetes.

Low cardiac function may accelerate brain aging Posted: 05 Aug 2010 05:00 PM PDT US researchers report that a decreased cardiac index, a measure of cardiac output in relation to body size, is associated with decreased brain volume – a sign of brain aging.

<i>CYP2C19</i> variant predicts poor clopidogrel response in PCI patients Posted: 05 Aug 2010 05:00 PM PDT Patients receiving high-maintenance dose clopidogrel after percutaneous coronary intervention are at increased risk for high post treatment platelet reactivity if they carry CYP2C19 risk alleles, show study results.

No benefit from infusional chemotherapy in early breast cancer Posted: 05 Aug 2010 05:00 PM PDT For patients with early-stage breast cancer, adjuvant treatment with intravenous epirubicin, cisplatin, and 5-fluorouracil shows no benefit in terms of reducing relapse rates over 5-FU, epirubicin, and cyclophosphamide, study results show.

CRASH-2: Tranexamic acid cuts mortality in trauma patients Posted: 05 Aug 2010 05:00 PM PDT Tranexamic acid reduces mortality in trauma patients with or at high risk for bleeding, shows a large, randomized, multinational study.

‘Rapid sequence spinal’ avoids general anesthesia in category-1 sections Posted: 05 Aug 2010 05:00 PM PDT Use of a "rapid sequence spinal" anesthesia protocol can minimize the need for general anesthesia in women requiring emergency cesarean sections, report UK researchers.

Functional recovery best after femoral nerve block for knee arthroplasty Posted: 05 Aug 2010 05:00 PM PDT Patients show better functional recovery at 6 weeks after total knee arthroplasty if they are given continuous femoral nerve block for postoperative pain relief rather than periarticular infiltration, research suggests.

Casopitant enhances ondansetron effect on PONV risk Posted: 05 Aug 2010 05:00 PM PDT Adding the oral neurokinin-1 receptor antagonist casopitant to ondansetron increases the proportion of patients who remain free of postoperative nausea and vomiting, shows a phase II study in high-risk patients.

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