Medical News

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• tPA gene therapy may reduce early vein graft thrombosis
• Retinal microvessel changes more common in lacunar stroke
• Nocardiosis a potentially fatal complication of anti-TNF-α therapy
• Tuberculosis risk with anti-TNF drugs varies by agent
• Salvage radical prostatectomy effective for recurrent prostate cancer
• <i>BRCA1</i> mutations particularly common in young Greek breast cancer patients
• Salvage radical prostatectomy effective for recurrent prostate cancer
• Pre-adipocyte differentiation impaired with obesity
• Gene variant disrupts insulin induction
• Diabetic retinopathy patients who could benefit from CABG going undetected
• Liraglutide beneficial in triple combination therapy
• Glutamic acid intake has independent BP-lowering effects
• Low mortality after post-STEMI PCI with targeted ICD implantation
• <i>BRCA1</i> mutations particularly common in young Greek breast cancer patients

tPA gene therapy may reduce early vein graft thrombosis Posted: 09 Jul 2009 05:00 PM PDT Gene therapy with human tissue plasminogen activator, results in fewer, less severe cyclic flow reductions and better blood flow after saphenous vein graft in pigs, say researchers.

Retinal microvessel changes more common in lacunar stroke Posted: 09 Jul 2009 05:00 PM PDT Abnormalities in the retinal microvasculature are more common in patients with lacunar stroke than they are in patients with other stroke subtypes, results of a multicenter study show.

Nocardiosis a potentially fatal complication of anti-TNF-α therapy Posted: 09 Jul 2009 05:00 PM PDT Disseminated nocardiosis is a rare but potentially fatal complication of treatment with tumour necrosis factor -α blockers used in the management of psoriasis.

Tuberculosis risk with anti-TNF drugs varies by agent Posted: 09 Jul 2009 05:00 PM PDT The risk of tuberculosis associated with anti-tumour necrosis factor therapy is greater with infliximab and adalimumab than with etanercept, French researchers report.

Salvage radical prostatectomy effective for recurrent prostate cancer Posted: 09 Jul 2009 05:00 PM PDT Salvage radical prostatectomy is a useful treatment option in patients with recurrent prostate cancer with a prostate-specific antigen level <10 ng/ml and expected survival of more than 10 years, say Italian scientists.

<i>BRCA1</i> mutations particularly common in young Greek breast cancer patients Posted: 09 Jul 2009 05:00 PM PDT Four common BRCA1 germ-line mutations are found in one in ten women with early-onset breast cancer, and around one in forty of all cases, a Greek hospital-based study shows.

Salvage radical prostatectomy effective for recurrent prostate cancer Posted: 09 Jul 2009 05:00 PM PDT Salvage radical prostatectomy is a useful treatment option in patients with recurrent prostate cancer with a prostate-specific antigen level <10 ng/ml and expected survival of more than 10 years, say Italian scientists.

Pre-adipocyte differentiation impaired with obesity Posted: 09 Jul 2009 05:00 PM PDT Swedish researchers have found that pre-adipocyte differentiation is impaired in the abdominal subcutaneous adipose tissue of obese people.

Gene variant disrupts insulin induction Posted: 09 Jul 2009 05:00 PM PDT A variant of the upstream transcription factor 1 gene results in a defective response to insulin that could contribute to an increased risk for developing dyslipidemias and coronary heart disease, a study suggests.

Diabetic retinopathy patients who could benefit from CABG going undetected Posted: 09 Jul 2009 05:00 PM PDT Approximately 25% of patients with diabetic retinopathy receiving ophthalmologic care as outpatients have a significant stenotic coronary artery disease, findings from a Japanese clinic show.

Liraglutide beneficial in triple combination therapy Posted: 09 Jul 2009 05:00 PM PDT LEAD-4 results show liraglutide provides significant improvements in glycemic control as part of triple combination therapy with metformin and rosiglitazone, report researchers in the journal Diabetes Care.

Glutamic acid intake has independent BP-lowering effects Posted: 09 Jul 2009 05:00 PM PDT Dietary intake of glutamic acid, an amino acid that is abundant in vegetable protein, is an independent determinant of blood pressure, a major epidemiologic study has shown.

Low mortality after post-STEMI PCI with targeted ICD implantation Posted: 09 Jul 2009 05:00 PM PDT Early risk stratification and targeted implantation of a cardioverter-defibrillator results in low mortality after ST-elevation myocardial infarction treated with primary percutaneous coronary intervention, researchers report.

<i>BRCA1</i> mutations particularly common in young Greek breast cancer patients Posted: 09 Jul 2009 05:00 PM PDT Four common BRCA1 germ-line mutations are found in one in ten women with early-onset breast cancer, and around one in forty of all cases, a Greek hospital-based study shows.

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