Friday, November 20, 2009

Medical News

Medical News

Cangrelor not CHAMPION for PCI patients

Posted: 19 Nov 2009 04:00 PM PST

Two CHAMPION trials show disappointing results for the novel fast-acting intravenous platelet inhibitor cangrelor before or after percutaneous coronary intervention, with no reduction in the rate of death, myocardial infarction, or revascularization at 48 hours compared with clopidogrel treatment.

Coiling for very small aneurysms ‘feasible and effective’

Posted: 19 Nov 2009 04:00 PM PST

Endovascular treatment of very small intracranial aneurysms is feasible and effective in more than 90% of cases, a meta-analysis of seven published studies suggests.

Responses to combined LABA–ICS therapy differ by COPD subtype

Posted: 19 Nov 2009 04:00 PM PST

Patients with various subtypes of chronic obstructive pulmonary disease differ in their response to inhaled treatment with a combined long-acting beta-agonist and corticosteroid, Korean study results show.

Exhaled breath profiling can distinguish asthma from COPD

Posted: 19 Nov 2009 04:00 PM PST

Molecular profiling of exhaled breath using an "electronic nose" can accurately distinguish patients with asthma from those with chronic obstructive pulmonary disease, say Dutch researchers.

Consistently poorly controlled asthma predicts exacerbations

Posted: 19 Nov 2009 04:00 PM PST

Consistently very poorly controlled asthma is a significant predictor for exacerbations in both children and adults, study results show.

First-episode psychosis patients ‘a diverse group’

Posted: 19 Nov 2009 04:00 PM PST

There is wide range of ages and diagnostic groups among patients with first-episode psychosis, warn UK investigators who highlight the lack of research and treatment guidelines for such patients.

No affective temperament gradient across patient diagnostic groups

Posted: 19 Nov 2009 04:00 PM PST

There is no gradient in affective temperament scores from bipolar I disorder through unipolar depressive patients to healthy individuals, say UK researchers who found high dysthymic scores in both patient groups.

IL-6 overexpression plus androgen withdrawal could reduce prostate cancer growth

Posted: 19 Nov 2009 04:00 PM PST

Overexpression of interleukin-6 in prostate cancer cells enhances their sensitivity to androgen withdrawal both in vitro and in vivo, say researchers who claim their study is the first to demonstrate the association.

IL-6 overexpression plus androgen withdrawal could reduce prostate cancer growth

Posted: 19 Nov 2009 04:00 PM PST

Overexpression of interleukin-6 in prostate cancer cells enhances their sensitivity to androgen withdrawal both in vitro and in vivo, say researchers who claim their study is the first to demonstrate the association.

Lapatinib monotherapy feasible for HER2-positive metastatic breast cancer

Posted: 19 Nov 2009 04:00 PM PST

Lapatinib monotherapy is an effective treatment for patients with human epidermal growth factor receptor 2-positive advanced or metastatic breast cancer that has relapsed after trastuzumab treatment, Japanese research suggests.

Dendritic cell ‘vaccine’ could counter atherosclerosis

Posted: 19 Nov 2009 04:00 PM PST

Vaccination using mature dendritic cells pulsed with oxidized low-density lipoprotein could provide a "powerful" strategy for the immunomodulation of atherosclerosis, claim Dutch researchers.

Lp-PLA<sub>2</sub> could predict vascular events in elderly

Posted: 19 Nov 2009 04:00 PM PST

Lipoprotein-associated phospholipase A2 may be a potential biomarker for vascular events in the elderly, a study suggests.

Early <i>H. pylori</i> eradication protects peptic ulcer patients against gastric cancer

Posted: 19 Nov 2009 04:00 PM PST

Early helicobacter pylori eradication reduces the risk for gastric cancer in patients with peptic ulcer disease, study findings show.

Long sleep duration may increase risk for Type 2 diabetes

Posted: 19 Nov 2009 04:00 PM PST

Long sleep duration is associated with increased risk for Type 2 diabetes, but the excess risk may be at least partly ameliorated by weight reduction, improved diet, and increased physical activity, say researchers.

Glucose-lowering therapy in diabetes ‘slows vasculopathy progression’

Posted: 19 Nov 2009 04:00 PM PST

Glucose-lowering therapy in people with diabetes improves the structure and function of the vasculature, which in turn helps slow the progression of coronary artery calcification, research suggests.

Dietary sodium advice prevents rehospitalization in HF

Posted: 19 Nov 2009 04:00 PM PST

Heart failure patients with preserved systolic function who are advised to restrict dietary sodium intake after discharge from hospital have a reduced risk for death and readmission, study results demonstrate.

Combined imaging recommended for suspected CAD

Posted: 19 Nov 2009 04:00 PM PST

Risk stratification of patients with suspected coronary artery disease can be improved by addition of multi-slice computed tomography coronary angiography to calcium scoring, study results in the European Heart Journal show.

Lapatinib monotherapy feasible for HER2-positive metastatic breast cancer

Posted: 19 Nov 2009 04:00 PM PST

Lapatinib monotherapy is an effective treatment for patients with human epidermal growth factor receptor 2-positive advanced or metastatic breast cancer that has relapsed after trastuzumab treatment, Japanese research suggests.

RE-DEEM: Dabigatran causes no safety concerns in phase II ACS trial

Posted: 18 Nov 2009 04:00 PM PST

When added to dual anti-platelet therapy, the orally administered direct thrombin inhibitor, dabigatran etexilate, results in a "low and acceptable bleeding rate" compared with placebo in patients who have suffered an acute myocardial infarction, according to data presentedat the American Heart Association 2009 Scientific Sessions in, Orlando, Florida, USA.

AF-associated stroke ‘a distinct pathophysiologic and clinical entity’

Posted: 18 Nov 2009 04:00 PM PST

Strokes associated with atrial fibrillation account for around one-third of the total and tend to be particularly severe, disabling, and likely to recur, research suggests.

TURP useful for excluding prostate cancer after negative biopsy

Posted: 18 Nov 2009 04:00 PM PST

Men with repeated negative biopsy results but persistent indications of prostate cancer may best have the disease ruled out by transurethral resection of the prostate, report Italian researchers.

AS feasible for favorable-risk prostate cancer patients

Posted: 18 Nov 2009 04:00 PM PST

Active surveillance is a feasible treatment option for men with favorable-risk prostate cancer, and for those who are over 70 years old with intermediate-risk disease, say Canadian researchers.

TURP useful for excluding prostate cancer after negative biopsy

Posted: 18 Nov 2009 04:00 PM PST

Men with repeated negative biopsy results but persistent indications of prostate cancer may best have the disease ruled out by transurethral resection of the prostate, report Italian researchers.

AS feasible for favorable-risk prostate cancer patients

Posted: 18 Nov 2009 04:00 PM PST

Active surveillance is a feasible treatment option for men with favorable-risk prostate cancer, and for those who are over 70 years old with intermediate-risk disease, say Canadian researchers.

Oocyte retrieval does not delay adjuvant chemotherapy

Posted: 18 Nov 2009 04:00 PM PST

Procedures to safeguard the fertility of young women with breast cancer do not significantly delay the start of adjuvant chemotherapy, US researchers report.

LDL cholesterol continues to decrease in USA, but still room for improvement

Posted: 18 Nov 2009 04:00 PM PST

Study results show that the prevalence of high low-density lipoprotein cholesterol in the USA has decreased significantly since 1999, but use of lipid lowering medications could still be improved.

Prostate specific antigen levels reduced by statin therapy

Posted: 18 Nov 2009 04:00 PM PST

Study results show that statin use reduces prostate-specific antigen levels in patients with prostate cancer.

Osteoprotegerin significantly elevated in Type 2 diabetic women

Posted: 18 Nov 2009 04:00 PM PST

The bone resorption inhibitor osteoprotegerin is significantly elevated in postmenopausal women with Type 2 diabetes compared with nondiabetic controls, say researchers.

Protamine-based insulin non-inferior to detemir for glycemic control

Posted: 18 Nov 2009 04:00 PM PST

A novel insulin formulation, insulin lispro protamine suspension, is non-inferior to insulin detemir for improving glycemic control in patients with Type 2 diabetes that is poorly controlled on oral hypoglycemic drugs, a randomized trial has shown.

AF-associated stroke ‘a distinct pathophysiologic and clinical entity’

Posted: 18 Nov 2009 04:00 PM PST

Strokes associated with atrial fibrillation account for around one-third of the total and tend to be particularly severe, disabling, and likely to recur, research suggests.

RE-DEEM: Dabigatran causes no safety concerns in phase II ACS trial

Posted: 18 Nov 2009 04:00 PM PST

When added to dual anti-platelet therapy, the orally administered direct thrombin inhibitor, dabigatran etexilate, results in a "low and acceptable bleeding rate" compared with placebo in patients who have suffered an acute myocardial infarction, according to data presentedat the American Heart Association 2009 Scientific Sessions in, Orlando, Florida, USA.

CT-STAT: CTA faster and cheaper than standard protocol for CAD diagnosis

Posted: 18 Nov 2009 04:00 PM PST

A protocol using initial computed tomography angiography is effective and both faster and cheaper than standard-of-care evaluation in the diagnosis of coronary artery disease among low-to-intermediate risk patients with chest pain, show results of the CT-STAT trial.

Chlorthalidone preferred over amlodipine, lisinopril as initial anti-hypertensive therapy in long-term ALLHAT follow-up

Posted: 18 Nov 2009 04:00 PM PST

Ten-year follow-up of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack trial confirmed the results from the 5-year trial demonstrating that an older drug, chlorthalidone, was as effective as drugs considered newer at the time the trial was initiated (ie, the calcium-channel blocker amlodipine, the ACE inhibitor lisinopril, and the alpha blocker doxazosin.

Oocyte retrieval does not delay adjuvant chemotherapy

Posted: 18 Nov 2009 04:00 PM PST

Procedures to safeguard the fertility of young women with breast cancer do not significantly delay the start of adjuvant chemotherapy, US researchers report.

Statin use can lower PSA level

Posted: 17 Nov 2009 04:00 PM PST

Prostate cancer patients who take statins have lower prostate-specific antigen levels than men who do not take the medication, but present with more aggressive stages of disease, study findings show.

Longer consultations improve patient satisfaction with surgical treatment

Posted: 17 Nov 2009 04:00 PM PST

Most low-income women with breast cancer are extremely satisfied with the treatment they received from their surgeon, study findings indicate.

Low-fat diet may decrease prostate cancer cell growth

Posted: 16 Nov 2009 04:00 PM PST

A low-fat diet, high in fiber and soy is associated with decreased prostate cancer cell growth, according to the results of a US trial.

RALP effective for radiation-resistant prostate cancer

Posted: 16 Nov 2009 04:00 PM PST

Prostate cancer patients who experience disease recurrence after radiation therapy can be effectively treated with salvage robot assisted laparoscopic radical prostatectomy, research findings show.

Biennial mammography recommended for women aged 50–74 years

Posted: 16 Nov 2009 04:00 PM PST

Six independent research groups have unanimously shown that biennial mammography screening of average risk women between the ages of 50 and 74 years old achieves most of the benefit of annual screening with less harm.

Prostate volume increase is not a reliable cancer screening tool

Posted: 15 Nov 2009 04:00 PM PST

Routine evaluation of prostate volume is not necessarily a reliable predictor of prostate cancer compared with rising levels of prostate-specific antigen, according to the results of a US study.

Anti-anemia drugs linked to VTE among patients with cancer

Posted: 15 Nov 2009 04:00 PM PST

Erythropoiesis-stimulating agents are associated with an increased risk for venous thromboembolism, but not mortality, in elderly patients with cancer, study findings indicate.
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