Medical News

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• <i>VEGF</i> variants tied to childhood asthma and lung function
• CRP levels not elevated in emphysema diagnosed by CT
• Elastin genetic variants rare in COPD
• Reward feedback altered in umedicated schizophrenia patients
• White matter hyperintensities independent of age common in BD patients
• Mental health patients account for 15% of hospital bed days
• Vitamin supplement use common in breast cancer patients
• Disenfranchised bowel disease patients at risk of early hospital self-discharge
• Fall in hormone therapy use linked to decrease in breast cancer incidence
• Fondaparinux frequently used ‘off-label’
• UK stroke strategy questioned
• Dynamic tumor bed volume in breast cancer patients after lumpectomy
• IL-6 levels linked to prostate cancer development and progress
• Metastasis suppressor 1 predicts outcome in breast cancer patients
• High small antral follicle count predicts pregnancy in women undergoing ART
• Worldwide increase seen in ART in recent years
• Genetic factors influencing age at menopause identified
• One-year survival of extremely preterm infants on the rise
• Gestational hypertension increases risk for Type 2 diabetes, hypertension
• Only vasomotor symptoms solely explained by menopausal transition
• Lifestyle modification best treatment for PCOS
• OC pharmacokinetics differ between obese, normal-weight women
• EE/CMA COC effective treatment for moderate acne, seborrhea
• Comparable outcomes for children born after cryopreservation, fresh cycles
• VAT more predictive of cardio-ankle vascular index than adiponectin
• Atherogenic LDL phenotype can be reversed through weight loss
• Exenatide once weekly offers greatest treatment satisfaction
• Revascularization no better than medical therapy for stable IHD in Type 2 diabetics
• RECORD final analysis finds no increased CV risk with rosiglitazone
• Miniature CPB linked with improved outcomes
• Stroke surgery waiting times 'unacceptable'

<i>VEGF</i> variants tied to childhood asthma and lung function Posted: 08 Jun 2009 05:00 PM PDT Genetic variations in vascular endothelial growth factor (VEGF) are associated with childhood asthma, lung function, and airway responsiveness, a family-based study has found.

CRP levels not elevated in emphysema diagnosed by CT Posted: 08 Jun 2009 05:00 PM PDT C-reactive protein levels are not significantly elevated in individuals with mild or moderate emphysema diagnosed by computed tomography, research shows.

Elastin genetic variants rare in COPD Posted: 08 Jun 2009 05:00 PM PDT Two identified single nucleotide polymorphisms in the elastin gene do not appear to be risk factors for severe chronic obstructive pulmonary disease, US research shows.

Reward feedback altered in umedicated schizophrenia patients Posted: 08 Jun 2009 05:00 PM PDT German study results suggest that drug-free schizophrenia patients process reward and loss-avoidance differently to others due to impairments in the medial prefrontal cortex and the ventral striatum.

White matter hyperintensities independent of age common in BD patients Posted: 08 Jun 2009 05:00 PM PDT A study has found that bipolar disorder patients have more severe frontal deep white matter lesions that are independent of age than those seen in healthy individuals.

Mental health patients account for 15% of hospital bed days Posted: 07 Jun 2009 05:00 PM PDT Patients with psychiatric disorders such as schizophrenia account for around 15% of NHS hospital bed days in England, study results show.

Vitamin supplement use common in breast cancer patients Posted: 07 Jun 2009 05:00 PM PDT Many women with breast cancer take high-dose antioxidant supplements while undergoing treatment for the disease, even though the consequences of doing so are not known, researchers have found.

Disenfranchised bowel disease patients at risk of early hospital self-discharge Posted: 07 Jun 2009 05:00 PM PDT Study results show that around one in every 76 US patients with inflammatory bowel disease who are admitted to hospital for emergency treatment leaves the hospital early against medical advice.

Fall in hormone therapy use linked to decrease in breast cancer incidence Posted: 07 Jun 2009 05:00 PM PDT The decrease in the incidence of breast cancer in the UK since 1999 may be partly due to a reduction in the use of hormone replacement therapy, say researchers.

Fondaparinux frequently used ‘off-label’ Posted: 07 Jun 2009 05:00 PM PDT The anticoagulant fondaparinux appears to be more often used for off-label than US Food and Drug Administration-approved indications, a US study has revealed.

UK stroke strategy questioned Posted: 07 Jun 2009 05:00 PM PDT The current emphasis on hyperacute stroke care to improve access to thrombolysis may distract attention and resources from a truly comprehensive stroke service, UK experts warn.

Dynamic tumor bed volume in breast cancer patients after lumpectomy Posted: 07 Jun 2009 05:00 PM PDT Patients who undergo breast-conserving surgery and radiotherapy continue to show changes in tumor bed volume after surgery and throughout radiation treatment, a study shows.

IL-6 levels linked to prostate cancer development and progress Posted: 07 Jun 2009 05:00 PM PDT Circulating interleukin -6 levels are associated with the development and progression of prostate cancer, but only among normal-weight men, US investigators have discovered.

Metastasis suppressor 1 predicts outcome in breast cancer patients Posted: 07 Jun 2009 05:00 PM PDT Metastasis suppressor 1 is a useful indicator of disease-free survival in breast cancer patients, as a result of its role in controlling the metastatic potential of breast tumor cells, study results suggest.

High small antral follicle count predicts pregnancy in women undergoing ART Posted: 07 Jun 2009 05:00 PM PDT The number of small antral follicles measuring between 2.1 and 4.0 mm is a significant predictor of viable pregnancy in women undergoing assisted reproduction treatment, suggest UK study results.

Worldwide increase seen in ART in recent years Posted: 07 Jun 2009 05:00 PM PDT A world collaborative report on assisted reproductive technology shows that the delivery rate and number of procedures is growing, despite a decline in the number of embryos transferred compared with previous years.

Genetic factors influencing age at menopause identified Posted: 07 Jun 2009 05:00 PM PDT Dutch researchers have identified genetic factors that influence the age at which natural menopause occurs in women.

One-year survival of extremely preterm infants on the rise Posted: 07 Jun 2009 05:00 PM PDT A Swedish study has found that as many as 70 percent of infants born alive between 22 and 26 weeks' gestation survive for at least 1 year, with high rates of interventions being used to improve survival.

Gestational hypertension increases risk for Type 2 diabetes, hypertension Posted: 07 Jun 2009 05:00 PM PDT Researchers have found that women with hypertensive pregnancy disorders have an increased risk for subsequent Type 2 diabetes mellitus and hypertension.

Only vasomotor symptoms solely explained by menopausal transition Posted: 07 Jun 2009 05:00 PM PDT Researchers have found that many commonly reported menopausal complaints may not be specifically related to the menopause, but are rather associated with ageing in general.

Lifestyle modification best treatment for PCOS Posted: 07 Jun 2009 05:00 PM PDT Lifestyle modification for treatment of polycystic ovary syndrome improves lipid profile and results in clinical pregnancy rates higher than those achieved with drug treatment alone, show study results.

OC pharmacokinetics differ between obese, normal-weight women Posted: 07 Jun 2009 05:00 PM PDT US study results suggest that biologic differences associated with greater hypothalamic–pituitary–ovarian activity exist between oral contraceptive users of differing body mass indexes, which may affect OC efficacy.

EE/CMA COC effective treatment for moderate acne, seborrhea Posted: 07 Jun 2009 05:00 PM PDT The monophasic combined oral contraceptive containing ethinylestradiol and chlormadinone acetate is an effective treatment for moderate papulopustular acne and other androgen-related skin disorders, study results suggest.

Comparable outcomes for children born after cryopreservation, fresh cycles Posted: 07 Jun 2009 05:00 PM PDT Obstetric outcomes are comparable or even better for children born after cryopreservation compared with those born after fresh cycles, suggest results from a systematic review.

VAT more predictive of cardio-ankle vascular index than adiponectin Posted: 07 Jun 2009 05:00 PM PDT Increased cardio-ankle vascular index, a marker of arterial stiffness, is associated with an increased area of visceral adipose tissue and reduced high-molecular weight adiponectin levels, report investigators.

Atherogenic LDL phenotype can be reversed through weight loss Posted: 07 Jun 2009 05:00 PM PDT Significant weight loss leads to reversion from an atherogenic to a non-atherogenic low-density lipoprotein phenotype in moderately overweight men, report researchers.

Exenatide once weekly offers greatest treatment satisfaction Posted: 07 Jun 2009 05:00 PM PDT Both twice-daily and once-weekly formulations of exenatide provided improvements in treatment satisfaction and quality of life when added to diet and exercise and/or other oral antidiabetes agents, report researchers in the journal Diabetic Medicine.

Revascularization no better than medical therapy for stable IHD in Type 2 diabetics Posted: 07 Jun 2009 05:00 PM PDT Rate of overall survival and freedom from cardiovascular events of Type 2 diabetes patients with ischemic heart disease does not differ significantly between patients treated with revascularization versus intensive medical therapy, show results from the BARI 2D trial.

RECORD final analysis finds no increased CV risk with rosiglitazone Posted: 07 Jun 2009 05:00 PM PDT Final results from the RECORD trial found no increase in the risk for cardiovascular hospitalization or death with rosiglitazone treatment, when added to standard metformin or sulfonylurea, in patients with Type 2 diabetes.

Miniature CPB linked with improved outcomes Posted: 07 Jun 2009 05:00 PM PDT Miniaturised cardiopulmonary bypass may be associated with a lower risk of postoperative stroke than the conventional approach, a meta-analysis of trials suggests.

Stroke surgery waiting times 'unacceptable' Posted: 04 Jun 2009 05:00 PM PDT Only 20% of UK patients have surgery to reduce their risk for stroke within the 2-week target time set by the National Institute for Health and Clinical Excellence, a UK study has found.

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