Medical News

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• Poor asthma control increases risk for depression
• Add-on montelukast may protect asthmatics against excessive airway narrowing
• Good doctor–patient communication key to good asthma management
• Parental bipolar disorder increases child’s psychopathology risk
• Novel mania scale allows diagnosis by non-professionals
• Factors involved in GI symptom persistence identified in primary care
• Extended use of dual antiplatet therapy after stent implantation questioned
• EXPLORE-Xa: Betrixaban bleeding outcomes comparable to warfarin in dose-finding trial
• EXPLORE-Xa: Betrixaban bleeding outcomes comparable to warfarin in dose-finding trial
• Great demand for new markers to improve prostate cancer diagnosis
• Better communication may improve understanding of genomic test results
• Mipomersen effective therapy for reducing LDL cholesterol in FH patients
• Adipocytes play key role in HDL hemostasis in vivo
• Dapagliflozin improves glycemic control and weight of Type 2 diabetics
• Extended use of dual antiplatet therapy after stent implantation questioned
• CABANA: pilot study finds catheter ablation more effective than antiarrhythmics
• RACE II: Lenient heart rate control in AF not inferior to strict control
• Diuretic plus CCB linked to higher MI risk than other combinations

Poor asthma control increases risk for depression Posted: 16 Mar 2010 05:00 PM PDT Asthma patients who believe they have poor control over their condition are more likely to develop depression than those who think they have good asthma control, US research shows.

Add-on montelukast may protect asthmatics against excessive airway narrowing Posted: 16 Mar 2010 05:00 PM PDT Asthma patients taking inhaled corticosteroids may benefit from add-on therapy with the leukotriene receptor antagonist montelukast to protect against excessive airway narrowing, say researchers.

Good doctor–patient communication key to good asthma management Posted: 16 Mar 2010 05:00 PM PDT Changing an asthma patient's inhaler device without their consent can damage the doctor–patient relationship and may even result in poorer asthma control, UK researchers warn.

Parental bipolar disorder increases child’s psychopathology risk Posted: 16 Mar 2010 05:00 PM PDT The risk for attention-deficit hyperactivity disorder and subthreshold manic and depressive symptoms is increased in preschool children of parents with bipolar disorder, the results of a US study indicate.

Novel mania scale allows diagnosis by non-professionals Posted: 16 Mar 2010 05:00 PM PDT A novel mania rating scales allows non-professionals in regular contact with a patient to diagnose a manic/mixed episode, say researchers who suggest the scale will complement current rating scales.

Factors involved in GI symptom persistence identified in primary care Posted: 16 Mar 2010 05:00 PM PDT Five factors measured during a primary care consultation for gastrointestinal symptoms can predict those patients who will have persistent symptoms, UK researchers report.

Extended use of dual antiplatet therapy after stent implantation questioned Posted: 15 Mar 2010 05:00 PM PDT Extending the duration of dual antiplatelet therapy for more than 12 months after receipt of drug-eluting stents in patients with no prior bleeding does not appear to be more effective than aspirin monotherapy for reducing the rate of myocardial infarction or cardiovascular death, researchers report.

EXPLORE-Xa: Betrixaban bleeding outcomes comparable to warfarin in dose-finding trial Posted: 15 Mar 2010 05:00 PM PDT The investigational anticoagulant betrixaban has a comparable safety profile to that of warfarin in patients with non-valvular atrial fibrillation or flutter, according to the results of EXPLORE-Xa trial.

EXPLORE-Xa: Betrixaban bleeding outcomes comparable to warfarin in dose-finding trial Posted: 15 Mar 2010 05:00 PM PDT The investigational anticoagulant betrixaban has a comparable safety profile to that of warfarin in patients with non-valvular atrial fibrillation or flutter, according to the results of EXPLORE-Xa trial.

Great demand for new markers to improve prostate cancer diagnosis Posted: 15 Mar 2010 05:00 PM PDT There is a great demand for new markers to improve prostate cancer diagnosis and prevent unnecessary prostate biopsies, especially in men with a serum prostate-specific antigen of 4–10 ng/ml, say researchers.

Better communication may improve understanding of genomic test results Posted: 15 Mar 2010 05:00 PM PDT US researchers report that a significant number of women do not fully understand discussions about their genomic-based recurrence risk for breast cancer.

Mipomersen effective therapy for reducing LDL cholesterol in FH patients Posted: 15 Mar 2010 05:00 PM PDT Treatment with the antisense inhibitor of apolipoprotein B synthesis mipomersen is a novel and effective way of reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia, say researchers.

Adipocytes play key role in HDL hemostasis in vivo Posted: 15 Mar 2010 05:00 PM PDT Researchers have shown, for the first time, that adipose tissue plays a role in maintaining levels of high-density lipoprotein cholesterol, acting through the ATP-binding cassette subfamily A member 1 and scavenger receptor class B type I cholesterol transporters.

Dapagliflozin improves glycemic control and weight of Type 2 diabetics Posted: 15 Mar 2010 05:00 PM PDT Study results show that dapagliflozin treatment improves the glycemic control and body weight of both early and late-stage Type 2 diabetics.

Extended use of dual antiplatet therapy after stent implantation questioned Posted: 15 Mar 2010 05:00 PM PDT Extending the duration of dual antiplatelet therapy for more than 12 months after receipt of drug-eluting stents in patients with no prior bleeding does not appear to be more effective than aspirin monotherapy for reducing the rate of myocardial infarction or cardiovascular death, researchers report.

CABANA: pilot study finds catheter ablation more effective than antiarrhythmics Posted: 15 Mar 2010 05:00 PM PDT Findings from a small pilot study show that catheter ablation is more effective than antiarrhythmic drug therapy for preventing recurrence of symptomatic atrial fibrillation in problematic patients with substantial underlying cardiovascular disease.

RACE II: Lenient heart rate control in AF not inferior to strict control Posted: 15 Mar 2010 05:00 PM PDT Less rigorous control of heart rate in patients with permanent atrial fibrillation appears to be as effective as strict rate control at preventing serious adverse events, including death from all causes, reported investigators from the RACE II study.

Diuretic plus CCB linked to higher MI risk than other combinations Posted: 04 Feb 2010 04:00 PM PST A case–control study in low-risk patients with hypertension suggests that treatment with a combination of diuretics and calcium channel blockers may be associated with an increased risk for myocardial infarction compared with other commonly used antihypertensive combination regimens including diuretics.

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