Medical News

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• Complications are common causes of early death in hospitalized COPD patients
• Poor asthma control among French children
• Gene therapy hope for people with alpha-1 antitrypsin deficiency
• Prefrontal cortex impairment underlies memory defects in schizophrenia
• Poor awareness of schizophrenia symptoms not linked to denial
• Specific FXa inhibition thromboprophylaxis ‘acceptable to clinicians’
• Modest BP reduction in acute stroke ‘may improve outcomes’
• Breast feeding reduces familial breast cancer risk
• CYP3A4 enzyme implicated in prostate cancer development
• TNF-α may mediate link between HDL cholesterol and vascular risk
• Raised LDL cholesterol predicts multiple lesions in ACS patients
• Biphasic and prandial insulins best for glycemic control
• Childhood cancer survivors have increased risk for diabetes
• Optimized CT angiography lowers radiation doses in CAD screening
• Focus on door-to-balloon times questioned

Complications are common causes of early death in hospitalized COPD patients Posted: 11 Aug 2009 05:00 PM PDT Cardiac failure, pneumonia, and pulmonary thromboembolism are the most common causes of early death in hospitalized patients with chronic obstructive pulmonary disease, study results suggest.

Poor asthma control among French children Posted: 11 Aug 2009 05:00 PM PDT Only about a quarter of asthmatic children in France have their disease under optimal control, say researchers who call for public health strategies to address the problem.

Gene therapy hope for people with alpha-1 antitrypsin deficiency Posted: 11 Aug 2009 05:00 PM PDT Patients with a genetic deficiency that increases the risk for emphysema could soon benefit from therapy to "replace" the defective gene, say researchers.

Prefrontal cortex impairment underlies memory defects in schizophrenia Posted: 11 Aug 2009 05:00 PM PDT Patients with schizophrenia consistently show diminished activity of the prefrontal cortex while performing episodic memory tasks, suggest results of a meta-analysis.

Poor awareness of schizophrenia symptoms not linked to denial Posted: 11 Aug 2009 05:00 PM PDT Patients with schizophrenia who show poor awareness of their illness symptoms generally have low levels of depression and anxiety, say US researchers who found no evidence that such patients employ denial mechanisms.

Specific FXa inhibition thromboprophylaxis ‘acceptable to clinicians’ Posted: 10 Aug 2009 05:00 PM PDT The specific factor Xa inhibitor apixaban may be suitable thromboprophylaxis for patients undergoing major joint replacement surgery, researchers suggest.

Modest BP reduction in acute stroke ‘may improve outcomes’ Posted: 10 Aug 2009 05:00 PM PDT The relationship between therapeutic changes in blood pressure and outcomes in acute stroke are "U" or "J"-shaped, indicating that modest reductions in BP may improve clinical outcomes.

Breast feeding reduces familial breast cancer risk Posted: 10 Aug 2009 05:00 PM PDT Breastfeeding may more than halve the risk for breast cancer in women with a family history of the disease, US study results show.

CYP3A4 enzyme implicated in prostate cancer development Posted: 10 Aug 2009 05:00 PM PDT Decreased expression of the cytochrome P450 3A4 enzyme contributes to the development of prostate cancer and provides clues to possible targets for new treatment, say researchers.

TNF-α may mediate link between HDL cholesterol and vascular risk Posted: 10 Aug 2009 05:00 PM PDT Low levels of high-density-lipoprotein cholesterol are an independent determinant of tumor necrosis factor-alpha concentrations in the Japanese population, research demonstrates.

Raised LDL cholesterol predicts multiple lesions in ACS patients Posted: 10 Aug 2009 05:00 PM PDT High levels of low-density-lipoprotein cholesterol together with carotid artery remodeling are useful markers of cardiovascular risk in men with acute coronary syndrome, Japanese researchers believe.

Biphasic and prandial insulins best for glycemic control Posted: 10 Aug 2009 05:00 PM PDT Biphasic and prandial insulin regimens may lead to better glycemic control than basal insulin when used as initial insulin therapy, but with significantly increased weight gain in the case of prandial insulin, show the results of a systematic review published in the journal Diabetologia.

Childhood cancer survivors have increased risk for diabetes Posted: 10 Aug 2009 05:00 PM PDT Survivors of childhood cancer have an elevated risk for developing diabetes in later life, suggest the results of a study published in the Archives of Internal Medicine.

Optimized CT angiography lowers radiation doses in CAD screening Posted: 10 Aug 2009 05:00 PM PDT Doctors testing for coronary artery disease have devised a novel way to reduce the dose of radiation delivered to patients during imaging with dual-source computed tomography.

Focus on door-to-balloon times questioned Posted: 10 Aug 2009 05:00 PM PDT National campaigns in the USA to minimize reperfusion delays in the treatment of patients with acute myocardial infarction have successfully reduced door-to-balloon times but had little impact on other performance measures or outcomes, study findings suggest.

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