Medical News

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• Mast cell degranulation linked to fatal asthma attack duration
• Swine flu vaccine trials to begin in children
• Chinese study supports protective effect of farming environment against asthma
• Substance abuse increases violence risk in schizophrenia
• Sleep and circadian activity abnormal in individuals at hypomania risk
• Pulmonary CTA useful for pediatric patients with suspicion of PE
• LAA-closure device shown effective for stroke prophylaxis in AF
• Three-marker methylation assay improves prostate cancer detection
• Men over 70 years more likely to have significant prostate cancer
• Three-marker methylation assay improves prostate cancer detection
• Men over 70 years more likely to have significant prostate cancer
• Disease-free survival reduced in node-positive breast cancer
• Statin trial for bioprosthesis valve deterioration ‘not justified’
• Adiponectin modestly predicts symptomatic PAD death
• Combination therapy may help Type 2 diabetics to fast during Ramadan
• Intensive treatment data supports individualized approach to glycemic control
• Personality Type D linked to increased mortality in PAD
• Doctor-pharmacist collaboration reduces HF hospitalizations in Australia
• Disease-free survival reduced in node-positive breast cancer
• Abnormal vascular features of prostate cancer help determine lesion position
• Antibody-based test detects BRCA2 truncated proteins
• Low risk for death from second cancer after radical prostatectomy
• Diabetes protection against prostate cancer ‘not due to sex hormones’
• National screening program reveals high breast cancer rates after SRT
• Dose escalation improves treatment results for intermediate-risk prostate cancer
• Vitamin D deficiency predicts poor breast cancer outcome

Mast cell degranulation linked to fatal asthma attack duration Posted: 20 Aug 2009 05:00 PM PDT The duration of fatal asthma attacks is partly determined by the degranulation of mast cells, results of an Australian study suggest.

Swine flu vaccine trials to begin in children Posted: 20 Aug 2009 05:00 PM PDT Trials of a candidate 2009 H1N1 vaccine are to begin in children after trials in adults raised no significant safety concerns, the US National Institute of Allergy and Infectious Diseases has announced.

Chinese study supports protective effect of farming environment against asthma Posted: 20 Aug 2009 05:00 PM PDT Children from rural areas of China are significantly less likely to have asthma and allergic sensitization than their urban counterparts, a finding that provides further evidence for a protective role of a farming environment against the development of childhood asthma and related atopic conditions, say researchers.

Substance abuse increases violence risk in schizophrenia Posted: 20 Aug 2009 05:00 PM PDT Although schizophrenia and other psychoses are associated with violence and violent offending, the majority of the risk appears to be conferred by substance abuse comorbidity, scientists have discovered.

Sleep and circadian activity abnormal in individuals at hypomania risk Posted: 20 Aug 2009 05:00 PM PDT Individuals at high risk for hypomania have alterations in sleep and circadian activity similar to those seen in bipolar disorder patients, indicating that such phenomena are not simply an artefact of the illness, conclude UK researchers.

Pulmonary CTA useful for pediatric patients with suspicion of PE Posted: 19 Aug 2009 05:00 PM PDT Study findings demonstrate the usefulness of pulmonary computed tomography angiography in children with suspected pulmonary embolism, even when venous thromboembolism is ruled out.

LAA-closure device shown effective for stroke prophylaxis in AF Posted: 19 Aug 2009 05:00 PM PDT A percutaneous device intended to close the left atrial appendage is non-inferior to standard warfarin therapy for preventing stroke in patients with atrial fibrillation, a randomized clinical trial has shown.

Three-marker methylation assay improves prostate cancer detection Posted: 19 Aug 2009 05:00 PM PDT A novel investigational assay for methylation on three prostate cancer markers in urine improves the performance of current screening algorithms for detecting the disease and may aid the treatment decision process, conclude US researchers.

Men over 70 years more likely to have significant prostate cancer Posted: 19 Aug 2009 05:00 PM PDT Men aged over 70 years are more likely to have larger, higher grade, and more clinically advanced prostate cancer than younger men, according to a US study.

Three-marker methylation assay improves prostate cancer detection Posted: 19 Aug 2009 05:00 PM PDT A novel investigational assay for methylation on three prostate cancer markers in urine improves the performance of current screening algorithms for detecting the disease and may aid the treatment decision process, conclude US researchers.

Men over 70 years more likely to have significant prostate cancer Posted: 19 Aug 2009 05:00 PM PDT Men aged over 70 years are more likely to have larger, higher grade, and more clinically advanced prostate cancer than younger men, according to a US study.

Disease-free survival reduced in node-positive breast cancer Posted: 19 Aug 2009 05:00 PM PDT Isolated tumor cells or micrometastases in regional lymph nodes are associated with a reduction in 5-year disease-free survival among women with favorable early-stage breast cancer who did not receive adjuvant therapy.

Statin trial for bioprosthesis valve deterioration ‘not justified’ Posted: 19 Aug 2009 05:00 PM PDT Canadian researchers have argued against running a trial to test whether statins prevent the deterioration of bioprosthesis structural valves.

Adiponectin modestly predicts symptomatic PAD death Posted: 19 Aug 2009 05:00 PM PDT Serum adiponectin concentrations modestly predict 5-year death rates in patients with symptomatic peripheral arterial disease, study findings suggest.

Combination therapy may help Type 2 diabetics to fast during Ramadan Posted: 19 Aug 2009 05:00 PM PDT A combination of insulin glargine and glimepiride may allow Muslims with Type 2 diabetes to fast during Ramadan, say researchers.

Intensive treatment data supports individualized approach to glycemic control Posted: 19 Aug 2009 05:00 PM PDT A meta-analysis of four major trials testing intensive glucose lowering underscores that modest reductions in major macrovascular events achieved with this approach are countered by an increase in major hypoglycemia, report investigators in the journal Diabetologia.

Personality Type D linked to increased mortality in PAD Posted: 19 Aug 2009 05:00 PM PDT Results of a pilot study suggest that patients with peripheral artery disease who have personality Type D, characterized by negative, inhibited personality traits, may have a significantly increased mortality risk.

Doctor-pharmacist collaboration reduces HF hospitalizations in Australia Posted: 19 Aug 2009 05:00 PM PDT Patients with heart failure whose doctors and pharmacists collaborate to help them adhere to medical therapy are less likely to be hospitalized than patients receiving usual management, a study in Australia found.

Disease-free survival reduced in node-positive breast cancer Posted: 19 Aug 2009 05:00 PM PDT Isolated tumor cells or micrometastases in regional lymph nodes are associated with a reduction in 5-year disease-free survival among women with favorable early-stage breast cancer who did not receive adjuvant therapy.

Abnormal vascular features of prostate cancer help determine lesion position Posted: 18 Aug 2009 05:00 PM PDT Dynamic contrast-enhanced magnetic resonance imaging discriminates between malignant lesions and healthy tissue in patients with prostate cancer, resulting in improved localization of tumors, according to UK research.

Antibody-based test detects BRCA2 truncated proteins Posted: 18 Aug 2009 05:00 PM PDT US researchers have developed a rapid, immunohistochemistry-based test that accurately identifies BRCA2 hereditary breast cancer without the need for genetic amplification or manipulation.

Low risk for death from second cancer after radical prostatectomy Posted: 17 Aug 2009 05:00 PM PDT Men who undergo radical prostatectomy have a 4% risk for death from a second cancer within 10 years of surgery, research shows.

Diabetes protection against prostate cancer ‘not due to sex hormones’ Posted: 17 Aug 2009 05:00 PM PDT The duration of diabetes mellitus is inversely associated with the risk for developing prostate cancer, but sex hormones, including testosterone, do not play a role in this protective effect, Iranian researchers have discovered.

National screening program reveals high breast cancer rates after SRT Posted: 17 Aug 2009 05:00 PM PDT Young women treated with supradiaphragmatic radiotherapy for Hodgkin's lymphoma are three times more likely than the general population to have breast cancer in later life, show results from a national notification risk assessment and screening program in the UK.

Dose escalation improves treatment results for intermediate-risk prostate cancer Posted: 16 Aug 2009 05:00 PM PDT Dose escalation in the form of intensity-modulated radiotherapy, or permanent transperineal brachytherapy either alone or in addition to external beam radiotherapy, produce better treatment outcomes than conventional dose three-dimensional conformal radiotherapy study findings show.

Vitamin D deficiency predicts poor breast cancer outcome Posted: 16 Aug 2009 05:00 PM PDT Low plasma vitamin D levels are associated with an increased risk for distant recurrence and death in women with breast cancer, Canadian researchers report.

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