Medical News

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• Once-weekly PR effective for improving exercise tolerance in COPD patients
• Allergic rhinitis a significant risk factor for asthma development
• Allergen exposure increases Th2-cytokines and FOXP3 expression in asthmatic lungs
• Subthreshold symptom persistence predicts progression to bipolar disorder
• Inferior frontal gyrus linked to schizophrenia familial risk
• Low dose rt-PA reduces bleeding risk, retains PTE efficacy
• GWTG–Stroke ensures treatment quality in older patients
• Raised vitamin D linked to pregnancy-associated breast cancer
• PSA screening for prostate cancer is less sensitive in USA than European trial
• Lipid profiles show distinct ethnic variation
• CCR5 area variants linked to HDL cholesterol and triglyceride level variation
• Risk for lower extremity amputation high in diabetics with high HbA1c
• High levels of soluble CD36 linked to increased diabetes risk
• Lipid profiles show distinct ethnic variation
• CHD risk knowledge could improve prevention take-up
• Prevention of torsade de pointes in hospital settings highlighted

Once-weekly PR effective for improving exercise tolerance in COPD patients Posted: 09 Feb 2010 04:00 PM PST Once-weekly is as effective as twice-weekly supervised pulmonary rehabilitation (PR) for improving exercise tolerance in patients with chronic obstructive pulmonary disease (COPD), but has less health-related quality-of-life benefits, UK researchers have found.

Allergic rhinitis a significant risk factor for asthma development Posted: 09 Feb 2010 04:00 PM PST The presence of allergic rhinitis (AR) is a significant risk factor for the development of asthma, research confirms.

Allergen exposure increases Th2-cytokines and FOXP3 expression in asthmatic lungs Posted: 09 Feb 2010 04:00 PM PST Patients with asthma have increased lung levels of T-helper cell type 2 (Th)2 cytokines, which may indicate that infiltrating FOXP3-positive (FOXP3+) cells are unable to control allergen-induced Th2 response in asthmatic lungs, say researchers.

Subthreshold symptom persistence predicts progression to bipolar disorder Posted: 09 Feb 2010 04:00 PM PST Study findings suggest that symptom persistence, rather than just presence of symptoms, predicts the transition to full-blown, clinically relevant bipolar disorder in young people with a subthreshold state.

Inferior frontal gyrus linked to schizophrenia familial risk Posted: 09 Feb 2010 04:00 PM PST In patients with schizophrenia, the subregion structure of the prefrontal cortex may be differentially affected, with the inferior frontal gyrus volume most related to familial risk, show US researchers.

Low dose rt-PA reduces bleeding risk, retains PTE efficacy Posted: 08 Feb 2010 04:00 PM PST For patients with pulmonary thromboembolism, a 50 mg/2-hour dose of recombinant tissue-type plasminogen activator offers similar benefits to a 100 mg/2-hour dose, but at a significantly reduced risk for bleeding, say Chinese researchers.

GWTG–Stroke ensures treatment quality in older patients Posted: 08 Feb 2010 04:00 PM PST Implementation of the Get With The Guidelines–Stroke program reduces age-related differences in acute ischemic stroke treatment, research shows.

Raised vitamin D linked to pregnancy-associated breast cancer Posted: 08 Feb 2010 04:00 PM PST A prospective study among pregnant Finnish women has revealed no association between vitamin D and premenopausal breast cancer, but did show that raised circulating vitamin D levels may be linked to an increased risk for pregnancy-associated breast cancer.

PSA screening for prostate cancer is less sensitive in USA than European trial Posted: 08 Feb 2010 04:00 PM PST A Dutch research team has shown that prostate-specific antigen screening protocols in the USA are less effective at identifying prostate cancer than those used in the European Randomized Study of Screening for Prostate Cancer.

Lipid profiles show distinct ethnic variation Posted: 08 Feb 2010 04:00 PM PST Lipid profiles show considerable variation according to race and ethnicity, research suggests, supporting the need for ethnically targeted strategies for the management of cardiovascular disease.

CCR5 area variants linked to HDL cholesterol and triglyceride level variation Posted: 08 Feb 2010 04:00 PM PST Four variants in the area of the chemokine receptor 5 gene are associated with variation in high-density lipoprotein cholesterol and triglyceride levels, show study results.

Risk for lower extremity amputation high in diabetics with high HbA1c Posted: 08 Feb 2010 04:00 PM PST Results from a systematic review and meta-analysis confirm that poor glycemic control in patients with diabetes leads to significantly increased risk for lower extremity amputation.

High levels of soluble CD36 linked to increased diabetes risk Posted: 08 Feb 2010 04:00 PM PST High levels of soluble CD36, a transmembrane glycoprotein, are associated with increased risk for Type 2 diabetes, show study results.

Lipid profiles show distinct ethnic variation Posted: 08 Feb 2010 04:00 PM PST Lipid profiles show considerable variation according to race and ethnicity, research suggests, supporting the need for ethnically targeted strategies for the management of cardiovascular disease.

CHD risk knowledge could improve prevention take-up Posted: 08 Feb 2010 04:00 PM PST Informing people of their global coronary heart disease risk score may improve how accurately they perceive their risk – and motivate those at moderate to high risk to take preventive measures, say researchers.

Prevention of torsade de pointes in hospital settings highlighted Posted: 08 Feb 2010 04:00 PM PST Hospital care providers should be aware of the particular risk faced by hospitalized patients for torsade de pointes brought on by QT-prolonging drugs, say experts on behalf of the American Heart Association and the American College of Cardiology Foundation.

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