Medical News

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• Wnt signaling genes linked to impaired lung function childhood asthma
• Increased CD203c expression on basophils linked to asthma exacerbations
• SES linked to stress response in children with asthma
• Prenatal tobacco exposure not linked to later schizophrenia
• Bipolar overdiagnosis in depression linked to worse outcomes
• Three esophageal cancer cell lines derived from other tumor types
• VASP, VerifyNow P2Y12 assays may best reflect clopidogrel responsiveness
• GWTG–Stroke program reaches 1 million patients
• <i>p53</i> mutation links deprivation to poor breast cancer outcome
• Metastasis after treatment for prostate cancer depends on disease risk
• Isoprostane levels high, increase with metabolic complications in obese children
• Leptin implicated in pathophysiology of arterial stiffness
• Framingham and UKPDS risk equations overestimate CV events in diabetics
• <i>SLC30A8</i> variant linked to increased Type 2 diabetes risk
• Sirolimus-eluting stent has comparable safety to CABG in multivessel disease
• Potassium channel variant linked to lone AF risk

Wnt signaling genes linked to impaired lung function childhood asthma Posted: 23 Feb 2010 04:00 PM PST Variants in Wnt signaling genes are associated with reduced lung function in children with asthma, study results suggest.

Increased CD203c expression on basophils linked to asthma exacerbations Posted: 23 Feb 2010 04:00 PM PST Basophil cells show increased expression of the surface marker CD203c during asthma exacerbations, suggesting the possibility that the marker could be used to monitor asthma control in patients, say researchers.

SES linked to stress response in children with asthma Posted: 23 Feb 2010 04:00 PM PST Asthmatic children from families with low socioeconomic status may experience more airway inflammation in response to stress than those from wealthier backgrounds, research suggests.

Prenatal tobacco exposure not linked to later schizophrenia Posted: 23 Feb 2010 04:00 PM PST Prenatal tobacco exposure does not increase the risk for schizophrenia in children, French scientists have discovered.

Bipolar overdiagnosis in depression linked to worse outcomes Posted: 23 Feb 2010 04:00 PM PST Depressed patients who are wrongly diagnosed with bipolar disorder are more chronically ill and have more comorbidities than depressed patients without this diagnosis, conclude US researchers.

Three esophageal cancer cell lines derived from other tumor types Posted: 23 Feb 2010 04:00 PM PST Three common human esophageal adenocarcinoma cell lines used in clinical research have been shown by research to be derived from other tumor types.

VASP, VerifyNow P2Y12 assays may best reflect clopidogrel responsiveness Posted: 22 Feb 2010 04:00 PM PST The flow cytometric vasodilator-stimulated phosphoprotein assay and the VerifyNow P2Y12 assay are the most appropriate platelet function tests to monitor peak plasma levels of the active metabolite of clopidogrel, study findings indicate.

GWTG–Stroke program reaches 1 million patients Posted: 22 Feb 2010 04:00 PM PST A million patients have now been treated under the Get With The Guidelines–Stroke project, which continues to deliver improvements in acute stroke care, shows the latest report.

<i>p53</i> mutation links deprivation to poor breast cancer outcome Posted: 22 Feb 2010 04:00 PM PST A mutation in the p53 gene is associated with a worse outcome among the most socio-economically deprived patients with breast cancer, researchers in the UK show.

Metastasis after treatment for prostate cancer depends on disease risk Posted: 22 Feb 2010 04:00 PM PST Men with high-risk prostate cancer are less likely to experience metastatic disease progression if they are treated with radical prostatectomy compared with external beam radiotherapy, report researchers.

Isoprostane levels high, increase with metabolic complications in obese children Posted: 22 Feb 2010 04:00 PM PST Results show that serum concentration of isoprostane, a marker of oxidative stress, is high in obese children and goes up further with increasing number of metabolic complications.

Leptin implicated in pathophysiology of arterial stiffness Posted: 22 Feb 2010 04:00 PM PST The adipokines – adiponectin, leptin, and resistin – are each independently correlated with arterial stiffness, an analysis of data from the Baltimore Longitudinal Study of Aging suggests.

Framingham and UKPDS risk equations overestimate CV events in diabetics Posted: 22 Feb 2010 04:00 PM PST The Framingham and UK Prospective Diabetes Study cardiovascular risk equations may lead to substantial overestimation of CV risk for the majority of Type 2 diabetics, report researchers.

<i>SLC30A8</i> variant linked to increased Type 2 diabetes risk Posted: 22 Feb 2010 04:00 PM PST Results from a systematic review and meta-analysis show that carriers of the C allele of a variant of the solute carrier family 30, member 8 gene have increased risk for Type 2 diabetes.

Sirolimus-eluting stent has comparable safety to CABG in multivessel disease Posted: 22 Feb 2010 04:00 PM PST Coronary stenting with sirolimus-eluting stents in patients with multivessel disease has a long-term safety record similar to that of coronary artery bypass graft surgery and superior to that of stenting with bare-metal stents, suggests research.

Potassium channel variant linked to lone AF risk Posted: 22 Feb 2010 04:00 PM PST Researchers have identified a novel genetic variant that may contribute to people's risk for developing lone atrial fibrillation.

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