Medical News

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• Most likely candidate genes for childhood asthma identified
• Socioeconomic status linked to lung function decline in men
• Cigar and pipe smoking may increase COPD risk
• Clinical features differ among absconding, agreed-leave patients committing suicide
• Corticolimbic dysregulation involved in BD pathophysiology
• SVT linked to increased risk for VTE
• Endogenous estradiol linked to women’s stroke risk
• Number, age of relatives with prostate cancer influences men’s prostate cancer risk
• Twice-yearly PSA test optimal for detection of prostate treatment failure
• Mammographic screening simulation suitable for hereditary breast cancer risk–benefit estimation
• Red yeast rice extract effective for treating children with dyslipidemia
• Paraoxonase 1 mediates kidney steroidogenesis
• ‘Fishy’ smell of metformin may put patients off
• Metformin may reduce cancer mortality for Type 2 diabetics
• Variants on 4q25 affect risk for AF recurrence after catheter ablation
• HRT not cardioprotective even shortly after menopause

Most likely candidate genes for childhood asthma identified Posted: 16 Feb 2010 04:00 PM PST A genome-wide association study of asthma in Mexican children has identified four genes most likely to be associated with development of the respiratory condition.

Socioeconomic status linked to lung function decline in men Posted: 16 Feb 2010 04:00 PM PST Low socioeconomic status is a significant, independent risk factor for increased lung function decline in men but not women, study results show.

Cigar and pipe smoking may increase COPD risk Posted: 16 Feb 2010 04:00 PM PST Cigar and pipe smoking is associated with reduced lung function and increased airflow limitation, and may increase an individual's risk for developing chronic obstructive pulmonary disease, say researchers.

Clinical features differ among absconding, agreed-leave patients committing suicide Posted: 16 Feb 2010 04:00 PM PST Researchers have confirmed study findings showing a substantial number of inpatient suicides after absconding from psychiatric wards, and that different clinical features exist between such patients and those who commit suicide off the ward but with agreed leave.

Corticolimbic dysregulation involved in BD pathophysiology Posted: 16 Feb 2010 04:00 PM PST Bipolar disorder patients experiencing an episode of mania show corticolimbic dysregulation characterized by simultaneous resting limbic/paralimbic hypermetabolism and prefrontal hypometabolism, indicate study findings.

SVT linked to increased risk for VTE Posted: 15 Feb 2010 04:00 PM PST Superficial venous thrombosis is not always a benign condition, say French researchers who believe it may herald venous thromboembolism in some patients.

Endogenous estradiol linked to women’s stroke risk Posted: 15 Feb 2010 04:00 PM PST Research shows that women's risk for stroke is influenced by their levels of circulating endogenous estrogen, although this may be mediated by adiposity.

Number, age of relatives with prostate cancer influences men’s prostate cancer risk Posted: 15 Feb 2010 04:00 PM PST Study findings confirm that men with multiple first-degree relatives are at increased risk for prostate cancer compared with men with no or few affected relatives.

Twice-yearly PSA test optimal for detection of prostate treatment failure Posted: 15 Feb 2010 04:00 PM PST Study results show that a prostate-specific antigen test should be carried out twice a year to optimize the detection of biochemical and clinical failure after prostate cancer treatment.

Mammographic screening simulation suitable for hereditary breast cancer risk–benefit estimation Posted: 15 Feb 2010 04:00 PM PST A simulation model developed to provide information on the benefits and risks for breast cancer screening in women with an increased risk for hereditary breast cancer accurately predicts the outcomes in the majority of cases, Dutch researchers report.

Red yeast rice extract effective for treating children with dyslipidemia Posted: 15 Feb 2010 04:00 PM PST Study results suggest that consumption of a dietary supplement containing red yeast rice extract and policosanols is effective for reducing low-density lipoprotein and total cholesterol levels in children with familial hypercholesterolemia or familial combined hyperlipidemia.

Paraoxonase 1 mediates kidney steroidogenesis Posted: 15 Feb 2010 04:00 PM PST Paraoxonase 1, a high-density lipoprotein-associated lipo-lactonase enzyme, plays a key role in regulating steroid synthesis in the kidney, a team of Israeli scientists has shown.

‘Fishy’ smell of metformin may put patients off Posted: 15 Feb 2010 04:00 PM PST A research letter published in the Annals of Internal Medicine brings to light a previously unreported "fishy" smell of metformin that could be responsible for many patients discontinuing the drug.

Metformin may reduce cancer mortality for Type 2 diabetics Posted: 15 Feb 2010 04:00 PM PST Patients with Type 2 diabetes who use metformin are at lower risk for cancer mortality than nonusers, report researchers.

Variants on 4q25 affect risk for AF recurrence after catheter ablation Posted: 15 Feb 2010 04:00 PM PST Polymorphisms on chromosome 4q25 linked to the development of atrial fibrillation may determine whether the arrhythmia recurs after catheter ablation, a small study shows.

HRT not cardioprotective even shortly after menopause Posted: 15 Feb 2010 04:00 PM PST Women may be at increased risk for coronary heart disease during the first 2 years of estrogen plus progestin hormone replacement therapy even if they start therapy within 10 years after the menopause, finds a newly published analysis of the Women's Health Initiative.

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