Medical News

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• Mannose-binding lectin deficiency not linked to COPD
• Maternal OCP use not linked to asthma risk in children
• Knowledge gaps revealed in patients’ asthma control
• Gray matter losses in youths with intellectual defects and schizotypy
• <i>DISC1</i> gene variants show mixed associations with psychiatric illness
• Variable biopsy findings common in childhood celiac disease
• Fixed sub-therapeutic dose LMWH ‘feasible’ for bridging anticoagulation
• Wider thrombolysis window ‘supported across patient subgroups’
• Improved biopsy protocol recommended in active surveillance
• Claudin expression shows potential as diagnostic marker in prostate cancer
• Estrogen receptor co-activators upregulated during aromatase inhibitor therapy
• Improved biopsy protocol recommended in active surveillance
• Claudin expression shows potential as diagnostic marker in prostate cancer
• SCD1 inhibitor plus fish oil protects against atherosclerosis
• Femoral, carotid plaques predict long-term CVD risk
• Eating fish regularly may prevent Type 2 diabetes
• Long-term mortality ‘substantially higher in diabetics’
• CVD raises hip fracture risk
• Aldosterone antagonist uptake low in heart failure
• Estrogen receptor co-activators upregulated during aromatase inhibitor therapy
• No increase in prostate cancer mortality when treatment is deferred
• Booster radiation dose reduces risks for local breast cancer relapse
• Prostate-specific antigen velocity should not guide biopsy decision
• Highly sensitive PSA assay can predict prostate cancer recurrence after RP
• HPV present in breast cancer tissue
• PSA persistence after prostate cancer surgery linked to worse outcomes
• Delayed surgery decreases survival in breast cancer patients with mammographic presentation

Mannose-binding lectin deficiency not linked to COPD Posted: 22 Oct 2009 05:00 PM PDT Mannose-binding lectin deficiency is not associated with chronic obstructive pulmonary disease, research shows.

Maternal OCP use not linked to asthma risk in children Posted: 22 Oct 2009 05:00 PM PDT Maternal oral contraceptive use before conception is not associated with an increased risk for asthma in children, say researchers.

Knowledge gaps revealed in patients’ asthma control Posted: 22 Oct 2009 05:00 PM PDT Most patients with asthma understand the importance of good asthma control, but their inappropriate use of controller and quick-relief medications does not reflect this knowledge, results of a US survey show.

Gray matter losses in youths with intellectual defects and schizotypy Posted: 22 Oct 2009 05:00 PM PDT Adolescents with mild intellectual impairment and schizotypal features have medial temporal gray matter losses comparable to populations at high risk for schizophrenia, UK researchers have discovered.

<i>DISC1</i> gene variants show mixed associations with psychiatric illness Posted: 22 Oct 2009 05:00 PM PDT Disrupted in schizophrenia 1 gene variants play a role in the development of psychiatric illness yet there is significant heterogeneity in clinically relevant variants between populations, say international scientists.

Variable biopsy findings common in childhood celiac disease Posted: 22 Oct 2009 05:00 PM PDT Duodenal involvement in children with celiac disease is often patchy and may show variable severity even within a single biopsy fragment, say researchers who say multiple endoscopic biopsies are necessary to diagnose the condition.

Fixed sub-therapeutic dose LMWH ‘feasible’ for bridging anticoagulation Posted: 21 Oct 2009 05:00 PM PDT The use of fixed sub-therapeutic doses of low molecular weight heparin as a bridging regimen in patients on long-term Vitamin-k Antagonist therapy is associated with a low risk for recurrent thrombosis and major bleeding even in high-risk patients, Italian researchers report.

Wider thrombolysis window ‘supported across patient subgroups’ Posted: 21 Oct 2009 05:00 PM PDT The treatment window for thrombolysis in acute ischemic stroke can be extended to 4.5 hours, a new analysis of clinical trial data indicates.

Improved biopsy protocol recommended in active surveillance Posted: 21 Oct 2009 05:00 PM PDT An improved biopsy protocol for prostate cancer patients considering active surveillance is recommended by researchers to avoid the risk of initial undersampling.

Claudin expression shows potential as diagnostic marker in prostate cancer Posted: 21 Oct 2009 05:00 PM PDT Patients with organ-confined or clinically advanced prostate cancer appear to have distinct claudin expression profiles, leading researchers to suggest that the protein could be a sensitive marker of prostate cancer progression.

Estrogen receptor co-activators upregulated during aromatase inhibitor therapy Posted: 21 Oct 2009 05:00 PM PDT Estrogen receptor co-activators and the human epidermal growth factor receptor -2/neu are upregulated in tumors during aromatase inhibitor therapy for breast cancer, research shows.

Improved biopsy protocol recommended in active surveillance Posted: 21 Oct 2009 05:00 PM PDT An improved biopsy protocol for prostate cancer patients considering active surveillance is recommended by researchers to avoid the risk of initial undersampling.

Claudin expression shows potential as diagnostic marker in prostate cancer Posted: 21 Oct 2009 05:00 PM PDT Patients with organ-confined or clinically advanced prostate cancer appear to have distinct claudin expression profiles, leading researchers to suggest that the protein could be a sensitive marker of prostate cancer progression.

SCD1 inhibitor plus fish oil protects against atherosclerosis Posted: 21 Oct 2009 05:00 PM PDT Combination treatment with fish oils and an inhibitor of stearoyl co-enzyme A desaturase 1 offers "dramatic" protection against both atherosclerosis and the metabolic syndrome in animals and may be a future clinical treatment option, say scientists.

Femoral, carotid plaques predict long-term CVD risk Posted: 21 Oct 2009 05:00 PM PDT Carotid and femoral atherosclerotic plaques, detected by ultrasound, predict the risk of cardiovascular disease in middle-aged men, findings from a decade-long study confirm.

Eating fish regularly may prevent Type 2 diabetes Posted: 21 Oct 2009 05:00 PM PDT Consuming white or oily fish at least once per week may reduce the risk for Type 2 diabetes, whereas high consumption of shellfish may increase this risk, report researchers in the journal Diabetes Care.

Long-term mortality ‘substantially higher in diabetics’ Posted: 21 Oct 2009 05:00 PM PDT Individuals with Type 1 or Type 2 diabetes mellitus have markedly increased long-term mortality compared with the general population, a Swiss study has found.

CVD raises hip fracture risk Posted: 21 Oct 2009 05:00 PM PDT Researchers report that hip fracture is between two and five times more common in people with cardiovascular disease than in those with no history of the disease.

Aldosterone antagonist uptake low in heart failure Posted: 21 Oct 2009 05:00 PM PDT Less than a third of patients hospitalized for heart failure in the USA receive guideline-recommended aldosterone antagonist therapy, despite being treated at centers participating in a quality improvement registry, study results show.

Estrogen receptor co-activators upregulated during aromatase inhibitor therapy Posted: 21 Oct 2009 05:00 PM PDT Estrogen receptor co-activators and the human epidermal growth factor receptor -2/neu are upregulated in tumors during aromatase inhibitor therapy for breast cancer, research shows.

No increase in prostate cancer mortality when treatment is deferred Posted: 20 Oct 2009 05:00 PM PDT Men who choose to defer treatment after a diagnosis of low-risk prostate cancer are no more likely to die from the disease than men who are treated immediately, study findings show.

Booster radiation dose reduces risks for local breast cancer relapse Posted: 20 Oct 2009 05:00 PM PDT Researchers have found that the risk for local breast cancer relapse is increased in young breast cancer patients and those with high-grade invasive ductal cancer, but can be reduced by a booster dose of radiation to the tumor bed.

Prostate-specific antigen velocity should not guide biopsy decision Posted: 19 Oct 2009 05:00 PM PDT Knowing a patient's prostate specific antigen velocity or using standardized velocity cut points does not help to determine whether a prostate biopsy is necessary, report US researchers.

Highly sensitive PSA assay can predict prostate cancer recurrence after RP Posted: 19 Oct 2009 05:00 PM PDT An ultrasensitive gold nanoparticle bio-barcode assay that can detect prostate-specific antigen levels of less than 0.1 ng/ml and is over 300 times more sensitive than commercial immunoassays has been developed by US researchers.

HPV present in breast cancer tissue Posted: 19 Oct 2009 05:00 PM PDT Australian researchers have demonstrated the presence of human papilloma virus in the nuclei of cells in breast cancer tissue, which they say indicates a possible role for high-risk HPV in human breast cancer.

PSA persistence after prostate cancer surgery linked to worse outcomes Posted: 18 Oct 2009 05:00 PM PDT Persistently elevated prostate-specific antigen levels after radical prostatectomy are associated with an increased risk for biochemical recurrence and overall mortality, US researchers have discovered.

Delayed surgery decreases survival in breast cancer patients with mammographic presentation Posted: 18 Oct 2009 05:00 PM PDT An interval of more than 12 weeks from clinical presentation to breast surgery may be associated with decreased survival for breast cancer patients with a mammographic presentation, say researchers.

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