Medical News

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• Alveolar and bronchial NO not associated with asthma control or severity
• New NHLBI asthma guidelines help predict exacerbations in high-risk patients
• Increased inflammation in the pulmonary arteries in fatal asthma
• Face perception, attentive functions linked to facial emotion recognition in schizophrenia
• BD diagnosis in elderly linked to rapid cognitive decline
• DVT origin of PE questioned in trauma patients
• Ankle–brachial index predicts CV risk in stroke patients
• Tumor size does not reliably predict basal-like breast cancer outcome
• Solitary positive apical prostate cancer margin ‘may affect outcomes’
• Dyskerin gene linked to extensive prostate cancer tumor growth
• Microdose transdermal E2 therapy effective for vulvovaginal symptoms
• Objective hot flash frequency comparable in Japanese, European Americans
• Mathematical tool predicts probability of pregnancy, multiples in IVF
• Cervical cancer prognostic models may underestimate survival
• LNG–IUS impairs sperm transport through cervical mucus
• Congenital malformation risk increased with folic acid inhibitors
• Risks to cancer survivor offspring ‘minimal’
• Oral growth factor inhibitor shows epithelial ovarian cancer promise
• IVF insurance, funding reduce multiple birth rates, improve outcome
• Novel diagnostic test for embryo viability developed
• Miglustat improves lipid profile in Type 1 Gaucher disease
• Cholesterol synthesis changes found in FCH
• Infection, inflammation explain Asian diabetes risk
• Benefits of ivabradine in angina reported in every-day practice
• Add-on basal or prandial insulin aids glycemic control in Type 2 diabetes
• Infection, inflammation explain Asian diabetes risk
• Benefits of ivabradine in angina reported in every-day practice
• End-systolic volume post-exercise predicts mortality in CHD
• Ankle–brachial index predicts CV risk in stroke patients

Alveolar and bronchial NO not associated with asthma control or severity Posted: 26 Oct 2009 05:00 PM PDT A study investigating the clinical potential of alveolar and bronchial nitric oxide measurements shows that these are not relevant markers in the management of patients with asthma.

New NHLBI asthma guidelines help predict exacerbations in high-risk patients Posted: 26 Oct 2009 05:00 PM PDT Very poorly controlled asthma, as defined by the latest US clinical guidelines, increases the risk for future exacerbations, research shows.

Increased inflammation in the pulmonary arteries in fatal asthma Posted: 26 Oct 2009 05:00 PM PDT A post-mortem study of individuals who died of asthma has shown increased inflammation in the periarterial region of the small pulmonary arteries.

Face perception, attentive functions linked to facial emotion recognition in schizophrenia Posted: 26 Oct 2009 05:00 PM PDT Study results suggest that patients with schizophrenia have impairments in both face perception and emotion perception abilities, with the impairment in face perception significantly predicting emotion perception.

BD diagnosis in elderly linked to rapid cognitive decline Posted: 26 Oct 2009 05:00 PM PDT Study results show that older adults with bipolar disorder have greater cognitive dysfunction and decline than mentally healthy individuals of similar age and education level.

DVT origin of PE questioned in trauma patients Posted: 25 Oct 2009 05:00 PM PDT US researchers have challenged the belief that pulmonary embolism in trauma patients originates from deep vein thrombosis of the pelvis and proximal lower limb blood vessels.

Ankle–brachial index predicts CV risk in stroke patients Posted: 25 Oct 2009 05:00 PM PDT Ankle–brachial blood pressure index predicts cardiovascular risk and mortality in patients with ischemic stroke or transient ischemic attack, research indicates.

Tumor size does not reliably predict basal-like breast cancer outcome Posted: 25 Oct 2009 05:00 PM PDT Tumor size is not consistently associated with distant disease recurrence or mortality in women with basal-like cancers, Canadian research shows.

Solitary positive apical prostate cancer margin ‘may affect outcomes’ Posted: 25 Oct 2009 05:00 PM PDT A solitary positive apical margin in prostate cancer is associated with worse biochemical recurrence, although it is not an independent predictor, conclude US scientists who say margin sites should form part of an assessment.

Dyskerin gene linked to extensive prostate cancer tumor growth Posted: 25 Oct 2009 05:00 PM PDT The DKC1 gene, encoding the nucleolar protein dyskerin, is upregulated in prostate cancer and appears to play a role in extensive tumor growth, potentially via protein biosythesis, German study findings indicate.

Microdose transdermal E2 therapy effective for vulvovaginal symptoms Posted: 25 Oct 2009 05:00 PM PDT Transdermal microdose estrogen therapy is both effective and well-tolerated in women reporting moderate-to-severe vulvovaginal menopausal symptoms, suggest US study results.

Objective hot flash frequency comparable in Japanese, European Americans Posted: 25 Oct 2009 05:00 PM PDT US study findings show that American women with Japanese ancestry are less likely to report hot flashes on standard questionnaires than American women of European descent, but show comparable hot flash numbers during objective monitoring.

Mathematical tool predicts probability of pregnancy, multiples in IVF Posted: 25 Oct 2009 05:00 PM PDT Researchers have developed a mathematical model that predicts the probability of delivery of singletons, twins, and higher order multiples based on the number of embryos transferred during IVF and maternal factors.

Cervical cancer prognostic models may underestimate survival Posted: 25 Oct 2009 05:00 PM PDT Study results show that prognostic models for patients with surgically treated early-stage cervical cancer show a general underestimation of recurrence-free survival or disease-specific survival when applied to other patient populations.

LNG–IUS impairs sperm transport through cervical mucus Posted: 25 Oct 2009 05:00 PM PDT Study results show that the high contraceptive efficacy of the levonorgestrel–intrauterine system occurs, in part, as a result of impaired sperm transport through the cervical mucus to the endometrial cavity.

Congenital malformation risk increased with folic acid inhibitors Posted: 25 Oct 2009 05:00 PM PDT Medications that antagonize the effects of folic acid are associated with an increased risk for congenital malformations, warn Israeli researchers who call on clinicians to avoid their use during pregnancy.

Risks to cancer survivor offspring ‘minimal’ Posted: 25 Oct 2009 05:00 PM PDT The offspring of childhood cancer survivors are no more at risk for malformations of death than other children, but they do have an increased risk for preterm birth and low birth weight, results of two studies indicate.

Oral growth factor inhibitor shows epithelial ovarian cancer promise Posted: 25 Oct 2009 05:00 PM PDT An oral vascular endothelial growth factor kinase inhibitor may offer a therapeutic benefit to patients with recurrent epithelial ovarian cancer, tubal cancer, or peritoneal cancer, US study findings suggest.

IVF insurance, funding reduce multiple birth rates, improve outcome Posted: 25 Oct 2009 05:00 PM PDT Countries with free access to assisted reproductive technology and US states with mandated IVF insurance coverage have a lower incidence of multiple births and show better outcomes than those not providing financial support, show findings from two studies presented at the 65th annual meeting of the American Society for Reproductive Medicine in Atlanta, Georgia.

Novel diagnostic test for embryo viability developed Posted: 25 Oct 2009 05:00 PM PDT US researchers have developed a novel non-invasive test for embryo viability, based on studying the metabolomic profile of embryos in culture, which may be more accurate than current tests.

Miglustat improves lipid profile in Type 1 Gaucher disease Posted: 25 Oct 2009 05:00 PM PDT Treatment with miglustat significantly improves the lipid profile of individuals with Type 1 Gaucher disease, study results published in the journal Atherosclerosis suggest.

Cholesterol synthesis changes found in FCH Posted: 25 Oct 2009 05:00 PM PDT A comparison of individuals with familial combined hyperlipidemia and their unaffected relatives has taken scientists a step closer to understanding causes of the lipid disorder.

Infection, inflammation explain Asian diabetes risk Posted: 25 Oct 2009 05:00 PM PDT Researchers believe they have identified the factors explaining why Chinese men have a high risk for diabetes despite relatively low levels of adiposity.

Benefits of ivabradine in angina reported in every-day practice Posted: 25 Oct 2009 05:00 PM PDT Ivabradine reduces heart rate and is highly effective and well tolerated in the treatment of patients with stable angina, investigators say

Add-on basal or prandial insulin aids glycemic control in Type 2 diabetes Posted: 25 Oct 2009 05:00 PM PDT Adding basal or prandial insulin to oral therapy in patients with Type 2 diabetes mellitus results in improved glycemic control compared with the addition of a biphasic insulin regimen, demonstrate results from the 4T trial.

Infection, inflammation explain Asian diabetes risk Posted: 25 Oct 2009 05:00 PM PDT Researchers believe they have identified the factors explaining why Chinese men have a high risk for diabetes despite relatively low levels of adiposity.

Benefits of ivabradine in angina reported in every-day practice Posted: 25 Oct 2009 05:00 PM PDT Ivabradine reduces heart rate and is highly effective and well tolerated in the treatment of patients with stable angina, investigators say

End-systolic volume post-exercise predicts mortality in CHD Posted: 25 Oct 2009 05:00 PM PDT End-systolic volume after exercise independently predicts mortality in patients with coronary heart disease, concludes a study published in the European Heart Journal.

Ankle–brachial index predicts CV risk in stroke patients Posted: 25 Oct 2009 05:00 PM PDT Ankle–brachial blood pressure index predicts cardiovascular risk and mortality in patients with ischemic stroke or transient ischemic attack, research indicates.

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