Medical News

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• Combined budesonide/formoterol therapy improves asthma control
• Dichloroacetate improves exercise performance, reduces oxidative stress in COPD
• Diet not significantly linked to adult asthma
• Raised ACC activity found in schizophrenia at-risk individuals
• <i>DTNBP1</i> gene mutations linked to bipolar disorder
• High rates of childhood IBD reported in Canada
• Guidelines on triple therapy use in ACS need expansion
• Migraine with aura ‘doubles risk for ischemic stroke’
• Epstein criteria predict organ-confined but not insignificant prostate cancer
• Epstein criteria predict organ-confined but not insignificant prostate cancer
• Clinical stage III and IV breast cancers require imaging
• Atorvastatin improves response to treatment for erectile dysfunction
• Social deprivation tied to greater atherosclerosis burden
• ALT level predicts prediabetes in German adults
• Lifestyle changes, metformin use can delay Type 2 diabetes for 10 years
• Sleep apnea-CV link bolstered
• Team-based care improves BP control in hypertension
• Social deprivation tied to greater atherosclerosis burden
• Migraine with aura ‘doubles risk for ischemic stroke’
• Clinical stage III and IV breast cancers require imaging
• PSAV and comorbidity predict mortality in relapsed prostate cancer patients
• Sextant biopsy unreliable for identifying prostate cancer suitable for focal-therapy
• High-activity myeloperoxidase genotypes may enhance adjuvant chemotherapy outcome
• No benefit in adjusting PSA thresholds according to BMI
• Risk for cerebral metastases elevated in triple-negative,HER2-positive breast cancers
• Solitary positive apical prostate cancer margin ‘may affect outcomes’
• Dyskerin gene linked to extensive prostate cancer tumor growth
• Tumor size does not reliably predict basal-like breast cancer outcome

Combined budesonide/formoterol therapy improves asthma control Posted: 29 Oct 2009 05:00 PM PDT A combination of budesonide/formoterol maintenance and reliever therapy in the same inhaler is more effective for improving key aspects of asthma control than physicians' choice of conventional best practice, study findings show.

Dichloroacetate improves exercise performance, reduces oxidative stress in COPD Posted: 29 Oct 2009 05:00 PM PDT Treatment with dichloroacetate improves physical performance while reducing exercise-induced systemic oxidative stress and inflammatory response in patients with chronic obstructive pulmonary disease, results of a Dutch study suggest.

Diet not significantly linked to adult asthma Posted: 29 Oct 2009 05:00 PM PDT Results of a UK study suggest that there is no clear association between dietary patterns and adult asthma.

Raised ACC activity found in schizophrenia at-risk individuals Posted: 29 Oct 2009 05:00 PM PDT Fronto-temporal connectivity appears to be intact in individuals at risk for developing schizophrenia, but this may be due to increased activity in the anterior cingulate cortex, conclude UK scientists.

<i>DTNBP1</i> gene mutations linked to bipolar disorder Posted: 29 Oct 2009 05:00 PM PDT Mutations in the dystrobrevin binding protein 1 gene are associated with bipolar disorder, say European researchers in findings that reinforce the genetic overlap between schizophrenia and bipolar disorder.

High rates of childhood IBD reported in Canada Posted: 29 Oct 2009 05:00 PM PDT Ontario has a very high rate of childhood-onset inflammatory bowel disease, say researchers who have developed an algorithm to accurately identify children with the condition from administrative data.

Guidelines on triple therapy use in ACS need expansion Posted: 28 Oct 2009 05:00 PM PDT US researchers call for improved guidance on use of anticoagulation and dual antiplatelet agent regimens in patients with acute coronary syndromes.

Migraine with aura ‘doubles risk for ischemic stroke’ Posted: 28 Oct 2009 05:00 PM PDT Migraine with aura is associated with a two-fold increased risk for ischemic stroke, shows US research published in the British Medical Journal.

Epstein criteria predict organ-confined but not insignificant prostate cancer Posted: 28 Oct 2009 05:00 PM PDT Radical prostatectomy patients have a high likelihood of organ-confined disease and 5-year freedom from disease recurrence if their initial biopsy results fit the Epstein criteria, study findings show.

Epstein criteria predict organ-confined but not insignificant prostate cancer Posted: 28 Oct 2009 05:00 PM PDT Radical prostatectomy patients have a high likelihood of organ-confined disease and 5-year freedom from disease recurrence if their initial biopsy results fit the Epstein criteria, study findings show.

Clinical stage III and IV breast cancers require imaging Posted: 28 Oct 2009 05:00 PM PDT Only patients with clinical stage III or IV breast cancer require baseline investigation for metastases, a review of radiological staging practice in asymptomatic breast cancer patients reveals.

Atorvastatin improves response to treatment for erectile dysfunction Posted: 28 Oct 2009 05:00 PM PDT Atorvastatin therapy improves the response to sildenafil of men with erectile dysfunction and hypercholesterolemia, report researchers.

Social deprivation tied to greater atherosclerosis burden Posted: 28 Oct 2009 05:00 PM PDT People living in socioeconomically deprived areas have an increased burden of carotid atherosclerosis that is not fully explained by either classic or emerging cardiovascular risk factors, show UK researchers.

ALT level predicts prediabetes in German adults Posted: 28 Oct 2009 05:00 PM PDT Alanine-aminotransferase is an independent predictor for impaired glucose tolerance, a precursor to Type 2 diabetes, show results from a German worksite population.

Lifestyle changes, metformin use can delay Type 2 diabetes for 10 years Posted: 28 Oct 2009 05:00 PM PDT Results from the Diabetes Prevention Program Outcomes Study reported in The Lancet show that the beneficial effects of lifestyle intervention or treatment with metformin for preventing or delaying the onset of Type 2 diabetes can persist for at least 10 years.

Sleep apnea-CV link bolstered Posted: 28 Oct 2009 05:00 PM PDT The occurrence of breathing disturbances during sleep can directly trigger cardiac arrhythmias in some individuals, study findings published in the Journal of the American College of Cardiology suggest.

Team-based care improves BP control in hypertension Posted: 28 Oct 2009 05:00 PM PDT A strategy of team-based care for patients with hypertension achieves greater reductions in blood pressure than standard intervention, results of a meta-analysis demonstrate.

Social deprivation tied to greater atherosclerosis burden Posted: 28 Oct 2009 05:00 PM PDT People living in socioeconomically deprived areas have an increased burden of carotid atherosclerosis that is not fully explained by either classic or emerging cardiovascular risk factors, show UK researchers.

Migraine with aura ‘doubles risk for ischemic stroke’ Posted: 28 Oct 2009 05:00 PM PDT Migraine with aura is associated with a two-fold increased risk for ischemic stroke, shows US research published in the British Medical Journal.

Clinical stage III and IV breast cancers require imaging Posted: 28 Oct 2009 05:00 PM PDT Only patients with clinical stage III or IV breast cancer require baseline investigation for metastases, a review of radiological staging practice in asymptomatic breast cancer patients reveals.

PSAV and comorbidity predict mortality in relapsed prostate cancer patients Posted: 27 Oct 2009 05:00 PM PDT Men with biochemically recurrent prostate cancer are at increased risk for all cause mortality if they have a rapid prostate-specific antigen velocity and few comorbidities, according to US researchers.

Sextant biopsy unreliable for identifying prostate cancer suitable for focal-therapy Posted: 27 Oct 2009 05:00 PM PDT The sextant biopsy method regularly used to assess men with rising prostate-specific antigen levels may not be able to accurately detect unilateral prostate cancer, study findings show.

High-activity myeloperoxidase genotypes may enhance adjuvant chemotherapy outcome Posted: 27 Oct 2009 05:00 PM PDT High-activity myeloperoxidase genotypes are associated with better survival among women with breast cancer receiving cyclophosphamide-containing therapy, particularly when followed by tamoxifen therapy, US researchers report.

No benefit in adjusting PSA thresholds according to BMI Posted: 26 Oct 2009 05:00 PM PDT Adjusting a man's prostate specific antigen threshold according to body mass index is not warranted, say US researchers investigating the link between obesity and low PSA levels.

Risk for cerebral metastases elevated in triple-negative,HER2-positive breast cancers Posted: 26 Oct 2009 05:00 PM PDT Patients with triple-negative or human epidermal growth factor receptor 2-positive breast cancer have a higher risk for cerebral metastases than patients bearing steroid receptor-positive/HER2-negative phenotype, research shows.

Solitary positive apical prostate cancer margin ‘may affect outcomes’ Posted: 25 Oct 2009 05:00 PM PDT A solitary positive apical margin in prostate cancer is associated with worse biochemical recurrence, although it is not an independent predictor, conclude US scientists who say margin sites should form part of an assessment.

Dyskerin gene linked to extensive prostate cancer tumor growth Posted: 25 Oct 2009 05:00 PM PDT The DKC1 gene, encoding the nucleolar protein dyskerin, is upregulated in prostate cancer and appears to play a role in extensive tumor growth, potentially via protein biosythesis, German study findings indicate.

Tumor size does not reliably predict basal-like breast cancer outcome Posted: 25 Oct 2009 05:00 PM PDT Tumor size is not consistently associated with distant disease recurrence or mortality in women with basal-like cancers, Canadian research shows.

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