Medical News

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• Thrombolysis time window may be expanded in selected patients
• β2-AR genotype influences treatment response in severe asthma
• Comorbid depression adversely impacts outcomes in COPD
• Women more susceptible than men to wood dust related respiratory symptoms
• Intravaginal polymer gel well-tolerated, acceptable to women for contraception
• Postmenopausal hormone therapy increases FSAP levels
• Mildly abnormal glucose test during pregnancy raises diabetes risk
• Genetic testing underused in women with high risk for breast, ovarian cancer
• Oral contraceptive efficacy potentially affected by BMI
• Cognitive performance declines in the perimenopause
• In vitro extreme drug resistance assay may predict EOC outcomes
• Gestational diabetes strongly increases risk for type 2 diabetes
• <i>H. pylori</i> affects PGI/II ratio detection of atrophic gastritis
• GERD in China linked with obesity and urban life
• Circadian gene not linked to schizophrenia and mood disorders
• Reduced ALIC at diagnosis points to worse 1-year schizophrenia outcome
• US National Football League players ‘have normal CVD risk factor profile’
• Circadian gene not linked to schizophrenia and mood disorders
• Early-onset mental health disorders linked to non-completion of education
• Gray matter deficits found in older bipolar disorder patients
• Insular cortex deficits linked to psychosis development
• Heart failure risk increased by heart disease-linked chromosome variant
• Neuroanatomic differences exist between intermediate-, early-onset BD
• Reduced gray matter volume occurs early in schizophrenia
• Hypomanic symptoms common in the immediate postpartum period
• Cytomegalovirus infection increases arterial blood pressure
• Hormonal therapy for breast cancer not often used in disadvantaged women

Thrombolysis time window may be expanded in selected patients Posted: 31 May 2009 05:00 PM PDT A new Science Advisory from the American Heart Association and the American Stroke Association endorses the use of intravenous recombinant tissue plasminogen activator at 3.0 to 4.5 hours after stroke in carefully selected patients.

β2-AR genotype influences treatment response in severe asthma Posted: 31 May 2009 05:00 PM PDT Genotypic differences in the β2-adrenergic receptor influence the response to a widely used asthma treatment, a study of hospitalized children has found.

Comorbid depression adversely impacts outcomes in COPD Posted: 31 May 2009 05:00 PM PDT Depression is highly prevalent among people with chronic obstructive pulmonary disease and may have an adverse impact on disease outcomes.

Women more susceptible than men to wood dust related respiratory symptoms Posted: 31 May 2009 05:00 PM PDT Female woodworkers, but not their male counterparts, are at an increased risk for developing cough or bronchitis, research shows.

Intravaginal polymer gel well-tolerated, acceptable to women for contraception Posted: 31 May 2009 05:00 PM PDT Canadian researchers have found that the Invisible Condom®, an intravaginal polymer gel with the option of added microbicide, is comfortable, well-tolerated, and acceptable to women when applied daily.

Postmenopausal hormone therapy increases FSAP levels Posted: 31 May 2009 05:00 PM PDT Researchers have found that cyclic or continuous combined hormone therapy regimens increase plasma measures of factor VII-activating protease, which may contribute to the coronary heart disease-protective effect seen in young postmenopausal women.

Mildly abnormal glucose test during pregnancy raises diabetes risk Posted: 31 May 2009 05:00 PM PDT Even mildly abnormal 50-g glucose challenge test results during pregnancy that do not indicate gestational diabetes mellitus are linked to an increased later risk for diabetes in young women, conclude Canadian scientists.

Genetic testing underused in women with high risk for breast, ovarian cancer Posted: 31 May 2009 05:00 PM PDT US researchers have found women who meet criteria for genetic counseling for breast/ovarian cancer risk rarely receive/have a low chance of receiving guideline-recommended advice and testing.

Oral contraceptive efficacy potentially affected by BMI Posted: 31 May 2009 05:00 PM PDT US study findings suggest there may be an association between body mass index and contraceptive efficacy with low-dose oral contraceptives.

Cognitive performance declines in the perimenopause Posted: 31 May 2009 05:00 PM PDT Perimenopause is associated with impaired cognitive performance characterized by a decrease in learning relative to premenopausal levels, study results suggest.

In vitro extreme drug resistance assay may predict EOC outcomes Posted: 31 May 2009 05:00 PM PDT The use of an in vitro extreme drug resistance assay may be useful in predicting drug response, platinum-resistance, and survival in epithelial ovarian cancer patients receiving chemotherapy after staging laparotomy, suggest study results.

Gestational diabetes strongly increases risk for type 2 diabetes Posted: 31 May 2009 05:00 PM PDT Women with gestational diabetes have more than a seven-fold increased risk for developing type 2 diabetes after birth than those who have a normoglycemic pregnancy, show results from a systematic review and meta-analysis.

<i>H. pylori</i> affects PGI/II ratio detection of atrophic gastritis Posted: 31 May 2009 05:00 PM PDT Pepsinogen tests to detect atrophic gastritis should take Helicobacter pylori infection into account, Korean research suggests.

GERD in China linked with obesity and urban life Posted: 31 May 2009 05:00 PM PDT Gastroesophageal reflux disease is associated with obesity and living in urban areas, an exploratory study in China suggests.

Circadian gene not linked to schizophrenia and mood disorders Posted: 28 May 2009 05:00 PM PDT It appears that variations in the CLOCK gene do not play a major role in the development of schizophrenia, bipolar disorder, or major depressive disorder, conclude Japanese investigators.

Reduced ALIC at diagnosis points to worse 1-year schizophrenia outcome Posted: 28 May 2009 05:00 PM PDT First-episode schizophrenia patients are more likely to have poor 1-year outcomes if they have a reduced area of the anterior limb of the internal capsule, potentially indicating fronto-thalamic connectivity disturbance, say German scientists.

US National Football League players ‘have normal CVD risk factor profile’ Posted: 28 May 2009 05:00 PM PDT A study has shown that a sample of US National Football League players had a similar rate of dyslipidemia, higher rate of hypertension, and lower rates of impaired fasting glucose and smoking than a sample of healthy young adult men.

Circadian gene not linked to schizophrenia and mood disorders Posted: 28 May 2009 05:00 PM PDT It appears that variations in the CLOCK gene do not play a major role in the development of schizophrenia, bipolar disorder, or major depressive disorder, conclude Japanese investigators.

Early-onset mental health disorders linked to non-completion of education Posted: 28 May 2009 05:00 PM PDT People who develop mental health disorders in childhood or adolescence are less likely to complete their education than mentally healthy people, and this association is true for patients living in both high- and middle- or low-income countries, research shows.

Gray matter deficits found in older bipolar disorder patients Posted: 28 May 2009 05:00 PM PDT Older bipolar disorder patients have inferior frontal lobe gray matter volume deficits, including in areas associated with the anterior limbic network, US researchers have discovered.

Insular cortex deficits linked to psychosis development Posted: 27 May 2009 05:00 PM PDT Researchers have found prominent gray matter changes in the insular cortex subregion in ultra-high-risk neuroleptic-naïve individuals who later developed psychosis.

Heart failure risk increased by heart disease-linked chromosome variant Posted: 27 May 2009 05:00 PM PDT A variant on chromosome 9p21 that is known to increase coronary heart disease risk also increases heart failure risk among White people, say US scientists who found only weak associations with other atherosclerotic outcomes.

Neuroanatomic differences exist between intermediate-, early-onset BD Posted: 27 May 2009 05:00 PM PDT Researchers have found the first evidence for a neuroanatomic difference between intermediate-onset and early-onset bipolar disorder in the form of sulcal deviations.

Reduced gray matter volume occurs early in schizophrenia Posted: 26 May 2009 05:00 PM PDT Study results show patients with schizophrenia have a reduced gray matter volume early in their illness compared with healthy individuals, although this difference diminishes with age.

Hypomanic symptoms common in the immediate postpartum period Posted: 26 May 2009 05:00 PM PDT Study results suggest that hypomanic symptoms are common in the postpartum period and are significantly increased from antenatal rates in the general population.

Cytomegalovirus infection increases arterial blood pressure Posted: 25 May 2009 05:00 PM PDT Cytomegalovirus infection is a risk factor for increased blood pressure, US research suggests.

Hormonal therapy for breast cancer not often used in disadvantaged women Posted: 19 May 2009 05:00 PM PDT The use of adjuvant hormonal therapy for breast cancer in socio-economically disadvantaged women is low, US study results show.

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