| Volumetric capnography no better than time-based methods for excluding PE Posted: 23 Dec 2009 04:00 PM PST Volume-based capnographic parameters do not appear to improve the performance of the more readily obtained alveolar deadspace fraction for exclusion of suspected pulmonary embolism in outpatients with positive D-dimer test results, research shows.  |
| Neuroprotective effect of statins ‘negligible’ Posted: 23 Dec 2009 04:00 PM PST Preoperative statin use among people undergoing coronary artery bypass graft surgery has little impact on the postoperative risk for stroke or encephalopathy, clinical research suggests.  |
| Socioeconomic status linked to asthma control Posted: 23 Dec 2009 04:00 PM PST People with a low socioeconomic status (SES), as measured according to education level, tend to have poorer asthma control than those with a higher SES, research shows.  |
| COPD increases risk for subclinical LV dysfunction Posted: 23 Dec 2009 04:00 PM PST The presence of chronic obstructive pulmonary disease (COPD) is associated with an increased risk for subclinical left ventricular (LV) dysfunction in vascular surgery patients, study results show.  |
| Healthy diet counteracts air pollution effects in asthmatic children Posted: 23 Dec 2009 04:00 PM PST closely to the Mediterranean diet helps protect the lung health of asthmatic children exposed to air pollution, research shows.  |
| Prefrontal dysfunction common to ADHD and pediatric bipolar disorder Posted: 23 Dec 2009 04:00 PM PST Both attention deficit hyperactivity disorder and pediatric bipolar disorder patients exhibit prefrontal dysfunction, although it is more extensive in the former group, conclude US researchers.  |
| Risk of suicide persists in first-episode psychosis patients Posted: 23 Dec 2009 04:00 PM PST First-episode psychosis (FEP) patients have a high risk for suicide attempt that remains prevalent for at least 7 years and is predicted by previous self-harm, Australian study findings indicate.  |
| Recollection shows endophenotype potential in schizophrenia Posted: 23 Dec 2009 04:00 PM PST Schizophrenia patients show memory deficits in both familiarity and recollection whereas their parents have deficits only in recollection, the results of a Canadian study indicate.  |
| Negative specific memory recall increased with hypomania risk Posted: 23 Dec 2009 04:00 PM PST Individuals at high risk for bipolar hypomania have increased access to negative specific memories, say UK researchers who suggest that encouraging positive memory recall may benefit bipolar disorder patients.  |
| High-dose 3DCRT well tolerated by prostate cancer patients Posted: 23 Dec 2009 04:00 PM PST A long-term follow-up study of prostate cancer patients in the Radiation Therapy Oncology Group 9406 study found that tolerance to high-dose 3DCRT remained excellent for up to 12 years.  |
| Claustrophobia hinders uptake of MR breast cancer screening by high risk women Posted: 23 Dec 2009 04:00 PM PST Claustrophobia is preventing a lot of women at high risk for breast cancer from undergoing supplemental magnetic resonance imaging, researchers report.  |
| Large, rare chromosomal deletions linked to severe early-onset obesity Posted: 23 Dec 2009 04:00 PM PST Large, rare chromosomal deletions contribute significantly to the genetic element of severe obesity, say researchers.  |
| CAS enhances statin effects on contralateral plaque stability in bilateral carotid stenosis Posted: 23 Dec 2009 04:00 PM PST Ipsilateral carotid artery stenting combined with intensive atorvastatin therapy is associated with enhanced contralateral plaque stability compared with atorvastatin therapy alone in patients with bilateral carotid stenosis, a Greek study has found.  |
| Beta cell failure is main determinant of impaired glucose tolerance Posted: 23 Dec 2009 04:00 PM PST Progressive loss of beta cell function is the main determinant of progression from normal glucose tolerance to impaired glucose tolerance, a US study has found.  |
| Stevioside inhibits artherosclerosis in obese insulin-resistant mice Posted: 23 Dec 2009 04:00 PM PST A Belgian study has found that the natural sweetner stevioside reduces atherosclerosis in obese insulin-resistant mice.  |
| Non-adherence partly explains clopidogrel ‘resistance’ in CAD, stroke Posted: 23 Dec 2009 04:00 PM PST Non-adherence to clopidogrel can be reliably assessed through measurement of its inactive carboxyl metabolite, say researchers who found this biomarker correlated with inhibition of platelet aggregation.  |
| Combined exercise test improves CV mortality prediction Posted: 23 Dec 2009 04:00 PM PST Combined exercise assessment of heart rate recovery and T-wave alternans is a powerful predictor for all-cause and cardiovascular mortality in a low-risk population, study results show.  |
| CY and DOX enhance bioactivity of GM-CSF–secreting breast tumor vaccine Posted: 22 Dec 2009 04:00 PM PST Low-dose cyclophosphamide and doxorubicin may augment vaccine-induced HER2-specific immunity in breast cancer patients, say researchers.  |
| Radiation and surgery for prostate cancer result in similar QoL ‘utility’ scores Posted: 22 Dec 2009 04:00 PM PST Prostate cancer patients treated with radical prostatectomy have similar quality of life utility scores 1 year after treatment as their peers receiving radiation therapy, despite having different symptom profiles, study findings show.  |
| Novel risk stratification tool effective at selecting prostate cancer patients at risk for BM Posted: 22 Dec 2009 04:00 PM PST Italian researchers have used a novel risk stratification tool to successfully evaluate which newly diagnosed prostate cancer patients require bone scans to detect potential bone metastasis.  |
| Preliminary study supports vascular benefit of PDE5 inhibition Posted: 22 Dec 2009 04:00 PM PST Administration of the phosphodiesterase type 5 inhibitor tadalafil citrate is associated with a reduction in oxidative stress and increased serum levels of paraoxonase-1, Turkish researchers have shown.  |
| Sirt1 promising new anti-obesity target Posted: 22 Dec 2009 04:00 PM PST Researchers have confirmed that the deacetylase Sirt1 plays an important role in regulating food intake and body weight in animals and could, therefore, be a novel anti-obesity target in humans.  |
| Intravitreal corticosteroids show early promise for diabetic retinopathy Posted: 22 Dec 2009 04:00 PM PST Intravitreal injections of the corticosteroid triamcinolone may slow the progression of diabetic retinopathy in people with macular edema, a clinical trial has found.  |
| Diabetic retinopathy linked to visceral fat accumulation, insulin resistance Posted: 22 Dec 2009 04:00 PM PST Diabetic retinopathy is associated with visceral fat accumulation and insulin resistance in patients with Type 2 diabetes, study results show.  |
| Blood pressure increases in normal range raise HF risk Posted: 22 Dec 2009 04:00 PM PST An increase in systolic blood pressure within the clinically normal range can increase the risk for heart failure, say researchers who found a linear relationship between normotensive SBP and HF risk.  |
| Annual coronary calcification questioned as end-point for CVD Posted: 22 Dec 2009 04:00 PM PST Annual change in coronary artery calcification does not appear to be a suitable surrogate end point for treatment trials in patients with cardiovascular disease or chronic kidney disease, results of a systematic review published in the Archives of Internal Medicine suggest.  |