Medical News

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• Volumetric capnography no better than time-based methods for excluding PE
• Neuroprotective effect of statins ‘negligible’
• Socioeconomic status linked to asthma control
• COPD increases risk for subclinical LV dysfunction
• Healthy diet counteracts air pollution effects in asthmatic children
• Prefrontal dysfunction common to ADHD and pediatric bipolar disorder
• Risk of suicide persists in first-episode psychosis patients
• Recollection shows endophenotype potential in schizophrenia
• Negative specific memory recall increased with hypomania risk
• High-dose 3DCRT well tolerated by prostate cancer patients
• Claustrophobia hinders uptake of MR breast cancer screening by high risk women
• Large, rare chromosomal deletions linked to severe early-onset obesity
• CAS enhances statin effects on contralateral plaque stability in bilateral carotid stenosis
• Beta cell failure is main determinant of impaired glucose tolerance
• Stevioside inhibits artherosclerosis in obese insulin-resistant mice
• Non-adherence partly explains clopidogrel ‘resistance’ in CAD, stroke
• Combined exercise test improves CV mortality prediction
• CY and DOX enhance bioactivity of GM-CSF–secreting breast tumor vaccine
• Radiation and surgery for prostate cancer result in similar QoL ‘utility’ scores
• Novel risk stratification tool effective at selecting prostate cancer patients at risk for BM
• Preliminary study supports vascular benefit of PDE5 inhibition
• Sirt1 promising new anti-obesity target
• Intravitreal corticosteroids show early promise for diabetic retinopathy
• Diabetic retinopathy linked to visceral fat accumulation, insulin resistance
• Blood pressure increases in normal range raise HF risk
• Annual coronary calcification questioned as end-point for CVD

Volumetric capnography no better than time-based methods for excluding PE Posted: 23 Dec 2009 04:00 PM PST Volume-based capnographic parameters do not appear to improve the performance of the more readily obtained alveolar deadspace fraction for exclusion of suspected pulmonary embolism in outpatients with positive D-dimer test results, research shows.

Neuroprotective effect of statins ‘negligible’ Posted: 23 Dec 2009 04:00 PM PST Preoperative statin use among people undergoing coronary artery bypass graft surgery has little impact on the postoperative risk for stroke or encephalopathy, clinical research suggests.

Socioeconomic status linked to asthma control Posted: 23 Dec 2009 04:00 PM PST People with a low socioeconomic status (SES), as measured according to education level, tend to have poorer asthma control than those with a higher SES, research shows.

COPD increases risk for subclinical LV dysfunction Posted: 23 Dec 2009 04:00 PM PST The presence of chronic obstructive pulmonary disease (COPD) is associated with an increased risk for subclinical left ventricular (LV) dysfunction in vascular surgery patients, study results show.

Healthy diet counteracts air pollution effects in asthmatic children Posted: 23 Dec 2009 04:00 PM PST closely to the Mediterranean diet helps protect the lung health of asthmatic children exposed to air pollution, research shows.

Prefrontal dysfunction common to ADHD and pediatric bipolar disorder Posted: 23 Dec 2009 04:00 PM PST Both attention deficit hyperactivity disorder and pediatric bipolar disorder patients exhibit prefrontal dysfunction, although it is more extensive in the former group, conclude US researchers.

Risk of suicide persists in first-episode psychosis patients Posted: 23 Dec 2009 04:00 PM PST First-episode psychosis (FEP) patients have a high risk for suicide attempt that remains prevalent for at least 7 years and is predicted by previous self-harm, Australian study findings indicate.

Recollection shows endophenotype potential in schizophrenia Posted: 23 Dec 2009 04:00 PM PST Schizophrenia patients show memory deficits in both familiarity and recollection whereas their parents have deficits only in recollection, the results of a Canadian study indicate.

Negative specific memory recall increased with hypomania risk Posted: 23 Dec 2009 04:00 PM PST Individuals at high risk for bipolar hypomania have increased access to negative specific memories, say UK researchers who suggest that encouraging positive memory recall may benefit bipolar disorder patients.

High-dose 3DCRT well tolerated by prostate cancer patients Posted: 23 Dec 2009 04:00 PM PST A long-term follow-up study of prostate cancer patients in the Radiation Therapy Oncology Group 9406 study found that tolerance to high-dose 3DCRT remained excellent for up to 12 years.

Claustrophobia hinders uptake of MR breast cancer screening by high risk women Posted: 23 Dec 2009 04:00 PM PST Claustrophobia is preventing a lot of women at high risk for breast cancer from undergoing supplemental magnetic resonance imaging, researchers report.

Large, rare chromosomal deletions linked to severe early-onset obesity Posted: 23 Dec 2009 04:00 PM PST Large, rare chromosomal deletions contribute significantly to the genetic element of severe obesity, say researchers.

CAS enhances statin effects on contralateral plaque stability in bilateral carotid stenosis Posted: 23 Dec 2009 04:00 PM PST Ipsilateral carotid artery stenting combined with intensive atorvastatin therapy is associated with enhanced contralateral plaque stability compared with atorvastatin therapy alone in patients with bilateral carotid stenosis, a Greek study has found.

Beta cell failure is main determinant of impaired glucose tolerance Posted: 23 Dec 2009 04:00 PM PST Progressive loss of beta cell function is the main determinant of progression from normal glucose tolerance to impaired glucose tolerance, a US study has found.

Stevioside inhibits artherosclerosis in obese insulin-resistant mice Posted: 23 Dec 2009 04:00 PM PST A Belgian study has found that the natural sweetner stevioside reduces atherosclerosis in obese insulin-resistant mice.

Non-adherence partly explains clopidogrel ‘resistance’ in CAD, stroke Posted: 23 Dec 2009 04:00 PM PST Non-adherence to clopidogrel can be reliably assessed through measurement of its inactive carboxyl metabolite, say researchers who found this biomarker correlated with inhibition of platelet aggregation.

Combined exercise test improves CV mortality prediction Posted: 23 Dec 2009 04:00 PM PST Combined exercise assessment of heart rate recovery and T-wave alternans is a powerful predictor for all-cause and cardiovascular mortality in a low-risk population, study results show.

CY and DOX enhance bioactivity of GM-CSF–secreting breast tumor vaccine Posted: 22 Dec 2009 04:00 PM PST Low-dose cyclophosphamide and doxorubicin may augment vaccine-induced HER2-specific immunity in breast cancer patients, say researchers.

Radiation and surgery for prostate cancer result in similar QoL ‘utility’ scores Posted: 22 Dec 2009 04:00 PM PST Prostate cancer patients treated with radical prostatectomy have similar quality of life utility scores 1 year after treatment as their peers receiving radiation therapy, despite having different symptom profiles, study findings show.

Novel risk stratification tool effective at selecting prostate cancer patients at risk for BM Posted: 22 Dec 2009 04:00 PM PST Italian researchers have used a novel risk stratification tool to successfully evaluate which newly diagnosed prostate cancer patients require bone scans to detect potential bone metastasis.

Preliminary study supports vascular benefit of PDE5 inhibition Posted: 22 Dec 2009 04:00 PM PST Administration of the phosphodiesterase type 5 inhibitor tadalafil citrate is associated with a reduction in oxidative stress and increased serum levels of paraoxonase-1, Turkish researchers have shown.

Sirt1 promising new anti-obesity target Posted: 22 Dec 2009 04:00 PM PST Researchers have confirmed that the deacetylase Sirt1 plays an important role in regulating food intake and body weight in animals and could, therefore, be a novel anti-obesity target in humans.

Intravitreal corticosteroids show early promise for diabetic retinopathy Posted: 22 Dec 2009 04:00 PM PST Intravitreal injections of the corticosteroid triamcinolone may slow the progression of diabetic retinopathy in people with macular edema, a clinical trial has found.

Diabetic retinopathy linked to visceral fat accumulation, insulin resistance Posted: 22 Dec 2009 04:00 PM PST Diabetic retinopathy is associated with visceral fat accumulation and insulin resistance in patients with Type 2 diabetes, study results show.

Blood pressure increases in normal range raise HF risk Posted: 22 Dec 2009 04:00 PM PST An increase in systolic blood pressure within the clinically normal range can increase the risk for heart failure, say researchers who found a linear relationship between normotensive SBP and HF risk.

Annual coronary calcification questioned as end-point for CVD Posted: 22 Dec 2009 04:00 PM PST Annual change in coronary artery calcification does not appear to be a suitable surrogate end point for treatment trials in patients with cardiovascular disease or chronic kidney disease, results of a systematic review published in the Archives of Internal Medicine suggest.

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