Medical News

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• Memory in bipolar I disorder linked to early functional outcomes
• Combination therapy benefits early-stage schizophrenia patients
• Patient selection is biggest challenge for phase I breast cancer trials
• Cell adhesion and migration molecules implicated in prostate cancer progression
• 12-core biopsy no more effective at detecting prostate cancer than 8-core
• Model estimates recurrence risk following ductal carcinoma in situ
• DASH diet could slash estimated CHD risk
• Positive US total and LDL cholesterol trends countered by triglyceride rises
• Diabetics have lower long-term CHD risk than nondiabetic AMI patients
• Ghrelin suppresses insulin secretion in healthy nondiabetics
• New strategies increase transcatheter aortic valve implantation suitability
• Tailored clopidogrel dosing improves post-PCI prognosis of <i>CYP 2C19</i> carriers

Memory in bipolar I disorder linked to early functional outcomes Posted: 08 Sep 2010 05:00 PM PDT Results from a Canadian study show that memory function is significantly associated with functional, but not clinical, outcomes after 6 months of treatment in bipolar I disorder patients who have experienced a first manic episode.

Combination therapy benefits early-stage schizophrenia patients Posted: 08 Sep 2010 05:00 PM PDT Psychosocial therapy combined with antipsychotic treatment improves medication adherence, insight, quality of life, and social functioning, and reduces relapse risk in patients with early-stage schizophrenia compared with antipsychotic treatment alone, research shows.

Patient selection is biggest challenge for phase I breast cancer trials Posted: 08 Sep 2010 05:00 PM PDT Around 20% of metastatic breast cancer patients who enter phase I clinical trials show a measurable benefit after 4 months, depending on their tumor characteristics and the biological activity of the novel agents, study results show.

Cell adhesion and migration molecules implicated in prostate cancer progression Posted: 07 Sep 2010 05:00 PM PDT Molecules that control cell migration and adhesion are under-expressed and differently distributed in prostate cancer compared with healthy tissue, show the results of an immunohistochemical study of prostate biopsy specimens.

12-core biopsy no more effective at detecting prostate cancer than 8-core Posted: 07 Sep 2010 05:00 PM PDT US study results indicate that prostate cancer detection is not improved by using a 12-core biopsy compared with an 8-core biopsy, flouting the assumption that more is better in prostate biopsy protocols.

Model estimates recurrence risk following ductal carcinoma in situ Posted: 07 Sep 2010 05:00 PM PDT US researchers have developed a nomogram that provides an individualized risk estimate for ipsilateral breast tumor recurrence in women with ductal carcinoma in situ treated with breast-conserving surgery.

DASH diet could slash estimated CHD risk Posted: 07 Sep 2010 05:00 PM PDT The Dietary Approaches to Stop Hypertension eating plan may reduce a person's estimated risk for coronary heart disease in the next 10 years by 18% compared with a typical American eating pattern, research suggests.

Positive US total and LDL cholesterol trends countered by triglyceride rises Posted: 07 Sep 2010 05:00 PM PDT There has been a trend toward an overall decrease in total cholesterol and low-density lipoprotein cholesterol levels in the USA in recent years, say researchers who attribute this in part to the increased use of lipid-lowering medication.

Diabetics have lower long-term CHD risk than nondiabetic AMI patients Posted: 07 Sep 2010 05:00 PM PDT Patients with Type 2 diabetes have a significantly lower 10-year incidence of coronary heart disease and cardiovascular mortality than nondiabetic patients with a first acute myocardial infarction.

Ghrelin suppresses insulin secretion in healthy nondiabetics Posted: 07 Sep 2010 05:00 PM PDT Results from a proof-of-concept study show that ghrelin reduces glucose-stimulated insulin secretion and subsequently lowers plasma glucose in healthy nondiabetic individuals.

New strategies increase transcatheter aortic valve implantation suitability Posted: 07 Sep 2010 05:00 PM PDT Researchers report that 97% of aortic stenosis patients are anatomically suitable for transcatheter aortic valve implantation if a two-device strategy is used and transapical, transaxillary, or direct aortic procedural routes are offered in addition to the traditional transfemoral route.

Tailored clopidogrel dosing improves post-PCI prognosis of <i>CYP 2C19</i> carriers Posted: 07 Sep 2010 05:00 PM PDT Clopidogrel-induced high on-treatment platelet reactivity, which is a predictor of poor patient prognosis after percutaneous coronary intervention, may be overcome in patients with the cytochrome 2C19 2* polymorphism by tailoring pre-intervention clopidogrel loading doses according to platelet reactivity, a study reports.

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