Medical News

Elderly AATD patients offer clues to disease pathogenesis Posted: 01 Apr 2009 05:00 PM PDT Individuals with symptomatic α1-antitrypsin deficiency who reach the age of 60 years face an unusually indolent disease course, possibly because they have an inherent resistance to respiratory toxins.

Sputum colour and bacterial load weakly correlated Posted: 01 Apr 2009 05:00 PM PDT A weak, although statistically significant, association exists between bacterial load and sputum color in patients with acute exacerbations of chronic obstructive pulmonary disease, research shows.

Exhaled breath condensate sheds lights on asthma pathogenesis Posted: 01 Apr 2009 05:00 PM PDT Levels of inflammatory lipid mediators in the breath increase with the presence and severity of asthma, indicating a link between oxidative stress and airway inflammation, a clinical study suggests.

mtDNA variants and brain pH differences seen in psychiatric disorders Posted: 01 Apr 2009 05:00 PM PDT A study has found mitochondrial DNA variations in the dorsolateral prefrontal cortex of patients with schizophrenia, and further haplogroup associations with brain pH levels for bipolar disorder.

Gender differences in link between abuse and mental health disorders Posted: 01 Apr 2009 05:00 PM PDT Women who suffer from severe mental illnesses are more likely to have been abused in childhood than other women, but the same is not true for men with mental health disorders, UK researchers have found.

Living in proximity to roads affects lung function in adults with asthma Posted: 31 Mar 2009 05:00 PM PDT Daily exposure to air pollution from traffic is associated with impaired lung function in adults with asthma, and the closer an individual lives to a road, the greater their lung function impairments, research shows.

Potential target to stop cancer growth identified Posted: 31 Mar 2009 05:00 PM PDT US scientists have uncovered another mechanism by which new blood vessel growth is regulated, potentially paving the way for novel therapies that cut off the blood supply to prostate tumours and other cancers and stop them growing.

Childhood abuse linked to psychosis in women only Posted: 31 Mar 2009 05:00 PM PDT Women who suffer from severe mental illnesses are more likely to have been abused in childhood than other women, but the same is not true for men, UK researchers have found.

Decline in peptic ulcers among South Asian people Posted: 31 Mar 2009 05:00 PM PDT There has been a significant decline in the prevalence of peptic ulcers among people in Asia since the late 1980s, results of a Malaysian study suggest.

ACTIVE-A: Clopidogrel effective for stroke prevention in patients with AF Posted: 31 Mar 2009 05:00 PM PDT Clopidogrel added to aspirin significantly reduces the risk for stroke compared with aspirin therapy alone in high-risk patients with atrial fibrillation who are deemed unsuitable for treatment with vitamin K antagonists.

Anxiety predicts early ADT after recurrence in older prostate cancer patients Posted: 31 Mar 2009 05:00 PM PDT Earlier androgen deprivation therapy initiation in older men with biochemical recurrence, which may worsen quality of life without survival benefits, is predicted by cancer anxiety, warn US researchers.

Few drawbacks with combined prostate cancer endocrine and radiotherapy Posted: 31 Mar 2009 05:00 PM PDT Adding radiotherapy to endocrine treatment for locally advanced prostate cancer increases symptoms, but the impact is acceptable, with little effect on long-term quality of life, and the survival benefit is substantial, say Scandinavian scientists.

Exonic expression differs between malignant and benign breast lesions Posted: 31 Mar 2009 05:00 PM PDT Many exons are expressed differentially between breast cancer and benign breast lesions, a retrospective analysis shows.

Cholesterol crystals linked to acute coronary events Posted: 31 Mar 2009 05:00 PM PDT Cholesterol crystals in coronary artery samples taken at autopsy are significantly associated with plaque disruption and death from acute coronary syndrome, show results of a study using new vacuum preservation techniques.

ARMYDA-RECAPTURE: Atorvastatin reloading improves PCI outcomes in statin users Posted: 31 Mar 2009 05:00 PM PDT Atorvastatin pre-treatment improves clinical outcomes in patients undergoing percutaneous coronary intervention, even if they are already chronic statin users, show results of the ARMYDA-RECAPTURE trial.

Leptin levels do not provide extra information on HF and CVD risk in elderly Posted: 31 Mar 2009 05:00 PM PDT Elevated levels of leptin are associated with an increased risk for congestive heart failure and cardiovascular disease in the elderly, but do not provide additional prognostic information beyond that provided by body mass index alone, say researchers.

Genetic evidence supports antioxidant role for adiponectin in diabetics Posted: 31 Mar 2009 05:00 PM PDT A variant of the gene encoding adiponectin is associated with variation in plasma total antioxidant status and levels of oxidized low-density lipoprotein in people with Type 2 diabetes, indicating an antioxidant role for adiponectin, say researchers.

People with diabetes say they lack information about the disease Posted: 31 Mar 2009 05:00 PM PDT A French survey of patients' views of Type 2 diabetes finds 85% of people would like more disease-related information to help them cope with their condition.

Fibrinogen gene mutations may influence CV risk from air pollution Posted: 31 Mar 2009 05:00 PM PDT Polymorphisms in the fibrinogen gene appear to influence the relationship between air pollution, fibrinogen levels, and the risk for acute atherothrombotic events, show results of genetic analyses.

Most obesity-related hypertension in men isolated diastolic or systodiastolic Posted: 31 Mar 2009 05:00 PM PDT Isolated diastolic hypertension and systodiastolic hypertension account for most cases of obesity-related hypertension in adult men, report researchers in the Archives of Internal Medicine.

Thoracoscopic approach feasible for EG esophageal leiomyoma Posted: 08 Mar 2009 05:00 PM PDT Minimally invasive resection of esophageal leiomyoma near or at the esophagogastric (EG) junction via a thoracoscopic approach is feasible, say Chinese researchers.

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