Medical News

HDM allergen results in secretion of dendritic cell-attracting chemokines Posted: 02 Apr 2009 05:00 PM PDT Exposure of the airway epithelium to house dust mite results in binding of this allergen to non-Toll pattern-recognition receptors, which initiates airway inflammation, US research shows.

Distal bronchi determine anticholinergic response in COPD Posted: 02 Apr 2009 05:00 PM PDT Inhaled anticholinergic agents induce bronchodilation throughout the lung but the effect in the distal rather than the proximal airways is the main determinant of functional improvement.

<i>Egr-1</i> gene variants linked with atopy in Chinese asthmatics Posted: 02 Apr 2009 05:00 PM PDT Variations in the gene encoding early growth response-1 are associated with plasma levels of immunoglobulin E and with the presence of atopy in asthmatic individuals, new research suggests.

Affective disorder family history in schizophrenia marker for distinct subtype Posted: 02 Apr 2009 05:00 PM PDT Study results suggest that schizophrenia patients with a family history of affective disorder may be a distinct subgroup in schizophrenia, and may be biologically more similar to patients with serious affective disorder.

Folic acid may benefit bipolar disorder patients Posted: 02 Apr 2009 05:00 PM PDT Bipolar disorder patients in an acute phase of mania may benefit from treatment with folic acid as an adjuvant to sodium valproate, research suggests.

Two-compound product benefits nail psoriasis patients Posted: 02 Apr 2009 05:00 PM PDT A two-compound ointment containing calcipotriol and betamethasone improves the symptoms of patients with nail psoriasis, an open-label study indicates.

Golimumab effective against skin and joint symptoms in psoriasis Posted: 02 Apr 2009 05:00 PM PDT The novel anti-tumour necrosis factor α agent golimumab improves both joint and skin symptoms in patients with psoriatic arthritis, research shows.

Rheumatologists surveyed on joint pain management in psoriasis patients Posted: 02 Apr 2009 05:00 PM PDT A US team has collated recommendations from rheumatologists on how dermatologists should deal with joint pain in patients with psoriasis.

Two-compound formulation proves effective for scalp psoriasis Posted: 02 Apr 2009 05:00 PM PDT Further evidence to support a once-daily combination treatment for scalp psoriasis has been reported in a study of calcipotriol plus betamethasone dipropionate.

Residual neuromuscular blockade affects sugammadex reversal speed Posted: 02 Apr 2009 05:00 PM PDT Residual neuromuscular blockade affects the speed by which sugammadex reverses the effects of rocuronium after surgery, US researchers say.

Pre-operative testing disputed for all ambulatory surgery Posted: 02 Apr 2009 05:00 PM PDT A randomized pilot study suggests that indicated pre-operative testing may not alter peri-operative adverse events in selected patients undergoing ambulatory surgery.

Propofol adverse events in sedated children may be rare Posted: 02 Apr 2009 05:00 PM PDT A study of almost 50,000 procedures in children indicates that serious events with the sedative propofol are rare, although minor incidents may be more common.

Pre-operative anemia adds to death risk in noncardiac surgery Posted: 02 Apr 2009 05:00 PM PDT A Canadian study suggests that a third of patients undergoing noncardiac surgery may be anemic, placing them at increased risk for death.

Folic acid may benefit bipolar disorder patients experiencing mania Posted: 01 Apr 2009 05:00 PM PDT Bipolar disorder patients who are experiencing an episode of mania may benefit from taking folic acid supplements in addition to their prescribed mood-stabilising drugs, research suggests.

Red meat-rich diet may harm health Posted: 01 Apr 2009 05:00 PM PDT Study results show that people with a diet rich in red and processed meat are more likely to die early, particularly from cardiovascular disease-related causes or cancer, than those who eat little red meat.

Screening reduces deaths from prostate cancer Posted: 01 Apr 2009 05:00 PM PDT Screening based on the prostate specific antigen test reduces deaths due to prostate cancer by around a fifth, the results of a Europe-wide study show.

Infliximab offers long-term relief for Crohn’s disease patients Posted: 01 Apr 2009 05:00 PM PDT Patients with Crohn's disease can achieve long-term control of their symptoms with the immune-suppressing drug infliximab, researchers report.

Optimal dose of novel ultra LMWH treatment determined Posted: 01 Apr 2009 05:00 PM PDT Researchers have demonstrated a highly significant dose–response effect for a novel ultra-low molecular weight heparin over a twelve-fold dose range in a multi-center, double-blinded study of total knee replacement patients.

Experience benefits accrue slowly for laparoscopic prostate surgery Posted: 01 Apr 2009 05:00 PM PDT Increasing surgeon experience in laparoscopic radical prostatectomy is linked to marked reductions in cancer recurrence, but benefits accrue more slowly than with open surgery, say scientists.

Brain metastases risk high with triple receptor-negative breast cancer Posted: 01 Apr 2009 05:00 PM PDT Women with triple receptor-negative breast cancer have a high risk for brain metastases and a poor outcome, report researchers from the University of Texas MD Anderson Cancer Center in Houston, USA.

Experience benefits accrue slowly for laparoscopic prostate surgery Posted: 01 Apr 2009 05:00 PM PDT Increasing surgeon experience in laparoscopic radical prostatectomy is linked to marked reductions in cancer recurrence, but benefits accrue more slowly than with open surgery, say scientists.

Mammography ‘life saving’ impact questioned Posted: 01 Apr 2009 05:00 PM PDT US researchers have questioned the claim that mammography saves lives, and suggest that women should be better informed on the risks and benefits of breast cancer screening.

Metabolic syndrome and diabetes linked to aortic valve calcification in MESA Posted: 01 Apr 2009 05:00 PM PDT Results from the Multi-Ethnic Study of Atherosclerosis cohort show that individuals with the metabolic syndrome or diabetes are at increased risk for incident aortic valve calcium, report researchers.

Disruption of autophagy allows fat accumulation to occur Posted: 01 Apr 2009 05:00 PM PDT Researchers have discovered that disruption of autophagy, a cellular process involved in lipid degradation, allows excessive accumulation of triglycerides and lipid droplets to occur, potentially contributing to conditions such as obesity and diabetes.

Insulin glargine associated with lower risk of acute MI than other insulins Posted: 01 Apr 2009 05:00 PM PDT Initiation of insulin glargine in patients with Type 2 diabetes is associated with a lower incidence of acute MI compared with other insulins, a retrospective analysis of healthcare claims finds.

Anti-diabetic action of bezafibrate confirmed Posted: 01 Apr 2009 05:00 PM PDT The anti-dyslipidemia drug bezafibrate has clinically important antidiabetic properties, confirm results from a large observational database in the UK.

‘Second factor’ atrial abnormalities predisposing to AF characterized Posted: 01 Apr 2009 05:00 PM PDT Researchers have identified bi-atrial abnormalities in patients with paroxysmal lone atrial fibrillation that are characterized by structural change, conduction abnormalities, and sinus node dysfunction.

Troponin-I elevation may forewarn of HF in the apparently healthy Posted: 01 Apr 2009 05:00 PM PDT Elevated cardiac troponin-I levels indicated a substantially increased risk for heart failure in a community-based sample of asymptomatic men, Swedish researchers report.

Brain metastases risk high with triple receptor-negative breast cancer Posted: 01 Apr 2009 05:00 PM PDT Women with triple receptor-negative breast cancer have a high risk for brain metastases and a poor outcome, report researchers from the University of Texas MD Anderson Cancer Center in Houston, USA.

Mammography ‘life saving’ impact questioned Posted: 01 Apr 2009 05:00 PM PDT US researchers have questioned the claim that mammography saves lives, and suggest that women should be better informed on the risks and benefits of breast cancer screening.

Anxiety predicts early ADT after recurrence in older prostate cancer patients Posted: 31 Mar 2009 05:00 PM PDT Earlier androgen deprivation therapy initiation in older men with biochemical recurrence, which may worsen quality of life without survival benefits, is predicted by cancer anxiety, warn US researchers.

Few drawbacks with combined prostate cancer endocrine and radiotherapy Posted: 31 Mar 2009 05:00 PM PDT Adding radiotherapy to endocrine treatment for locally advanced prostate cancer increases symptoms, but the impact is acceptable, with little effect on long-term quality of life, and the survival benefit is substantial, say Scandinavian scientists.

Exonic expression differs between malignant and benign breast lesions Posted: 31 Mar 2009 05:00 PM PDT Many exons are expressed differentially between breast cancer and benign breast lesions, a retrospective analysis shows.

MRI diffusion measure may improve prostate cancer management Posted: 30 Mar 2009 05:00 PM PDT In prostate cancer, the apparent diffusion coefficient on magnetic resonance imaging is correlated with cell density, which may help to characterize the tumor and aid in management decisions, say UK scientists.

Hyperinsulinemia in breast cancer patients reflects underlying insulin resistance Posted: 30 Mar 2009 05:00 PM PDT In women with newly diagnosed breast cancer, high levels of insulin are associated with insulin resistance as well as other components of the metabolic syndrome, a Canadian study finds.

Raised ECD/HER2 associated with poor survival in metastatic breast cancer Posted: 30 Mar 2009 05:00 PM PDT Elevated plasma levels of the extracellular domain of the human epidermal growth factor receptor are strongly associated with decreased survival in women with metastatic breast cancer, study results show.

One-time prostate cancer screening offers attendee benefits Posted: 29 Mar 2009 05:00 PM PDT While one-time prostate cancer screening does not appear to offer a survival benefit for invited men versus the source population, there may be a benefit for attendees specifically, conclude Swedish and Italian scientists.

PSA velocity predicts adverse histology on untreated prostate cancer Posted: 29 Mar 2009 05:00 PM PDT Adverse histology on repeat biopsy in men with untreated, localized prostate cancer is more accurately predicted by prostate-specific antigen velocity than doubling time, say UK researchers.

Male circumcision helps prevent HPV, HSV-2 Posted: 29 Mar 2009 05:00 PM PDT Male circumcision significantly reduces the incidence of herpes simplex virus type 2 and human papillomavirus infections, US study results suggest.

Differential gene expression profiles for short-, long-term ovarian cancer survivors Posted: 29 Mar 2009 05:00 PM PDT A US study has found that ovarian cancers detected at an early stage have gene expression profiles that correlate with favorable outcome, while late-stage ovarian cancers seem to have a more virulent biology, thus highlighting the potential challenges of developing a screening test for the disease.

Clomiphene citrate plus vitamin E potential therapy for idiopathic oligozoospermia Posted: 29 Mar 2009 05:00 PM PDT Clomiphene citrate and vitamin E combination therapy increases pregnancy rates and improves sperm count and progressive sperm motility in men with idiopathic oligoasthenozoospermia, a study suggests.

<i>PALB2</i> mutations associated with breast cancer susceptibility in Chinese women Posted: 29 Mar 2009 05:00 PM PDT Two protein-truncating mutations in PALB2 are present in some BRCA1/2-negative Chinese women with early onset breast cancer, a study shows.

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