Medical News

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• Roflumilast benefits COPD patients
• Novel index better predicts mortality in COPD
• Surveillance systems for swine flu ‘effective’
• Reduced life satisfaction forms key aspect of stigma experience in schizophrenia
• High BMI linked to poor outcome in bipolar disorder
• proCPU levels alter thrombosis risk in thrombophilic patients
• RE-LY: Dabigatran lowers stroke risk versus warfarin in AF patients
• PLATO: Ticagrelor beats clopidogrel in ACS
• CURRENT OASIS-7: Doubling clopidogrel dosing has ‘favorable net clinical benefit’
• AAA study finds no benefit of aspirin in asymptomatic atherosclerosis
• “Spot sign” scoring system predicts hematoma expansion in ICH
• Binge-drinking increases risk of fatal stroke
• RE-LY: Dabigatran lowers stroke risk versus warfarin in AF patients
• AAA study finds no benefit of aspirin in asymptomatic atherosclerosis
• Glutamate dysfunction linked to reduced cortical gray matter volume in psychosis
• G72 gene variation linked to temporal, amygdala gray matter reductions in BD
• Racial disparity decreasing in US prostate cancer patients
• Patient involvement affects mastectomy decision
• Lipid control in high-risk CAD patients ‘improved but not satisfactory’
• Nevirapine boosts HDL cholesterol via apoA-I production
• Atorvastatin improves cardiometabolic risk factors in people with prediabetes
• Rosiglitazone improves arterial stiffness in Type 2 diabetes
• GISSI-HF: Rosuvastatin may reduce new-onset AF in HF patients
• B-CONVINCED: No need to interrupt beta-blockers in acutely decompensated HF
• RE-LY: Dabigatran lowers stroke risk versus warfarin in AF patients
• PLATO: Ticagrelor beats clopidogrel in ACS
• CURRENT OASIS-7: Doubling clopidogrel dosing has ‘favorable net clinical benefit’
• AAA study finds no benefit of aspirin in asymptomatic atherosclerosis

Roflumilast benefits COPD patients Posted: 01 Sep 2009 05:00 PM PDT The phosphodiesterase-4 inhibitor roflumilast helps improve lung function and reduces the risk for exacerbations in some patients with chronic obstructive pulmonary disease, two studies published in The Lancet suggest.

Novel index better predicts mortality in COPD Posted: 01 Sep 2009 05:00 PM PDT A novel scoring index for predicting a patient's risk for dying from chronic obstructive pulmonary disease is more accurate than the current BODE index and is much more applicable in clinical practice, say researchers.

Surveillance systems for swine flu ‘effective’ Posted: 01 Sep 2009 05:00 PM PDT Results of a UK study show that concerns about the effectiveness of flu surveillance systems during the early phase of the swine flu pandemic in England are unfounded.

Reduced life satisfaction forms key aspect of stigma experience in schizophrenia Posted: 01 Sep 2009 05:00 PM PDT The extent of stigma experienced by patients diagnosed with schizophrenia may be relatively independent of disease severity, with reduced life satisfaction forming a key aspect of the subjective experience of stigma, suggest study results.

High BMI linked to poor outcome in bipolar disorder Posted: 01 Sep 2009 05:00 PM PDT Bipolar disorder patients with elevated body mass index are more likely to experience a more severe disease course in terms of chronicity, duration of illness, and overall functioning, suggest study results.

proCPU levels alter thrombosis risk in thrombophilic patients Posted: 31 Aug 2009 05:00 PM PDT A variant gene that increases levels of procarboxypeptidase U raises the risk for thrombosis in thrombophilic patients, suggests study findings.

RE-LY: Dabigatran lowers stroke risk versus warfarin in AF patients Posted: 31 Aug 2009 05:00 PM PDT Treatment with dabigatran significantly reduces stroke risk in comparison with warfarin in patients with atrial fibrillation and at least one risk factor, results of the Randomized Evaluation of Long-term anticoagulant therapY trial show.

PLATO: Ticagrelor beats clopidogrel in ACS Posted: 31 Aug 2009 05:00 PM PDT The novel antiplatelet therapy ticagrelor reduces the rate of cardiovascular events and death compared with clopidogrel treatment in patients with acute coronary syndrome, without any increase in major bleeding events, the PLATO trial results indicate.

CURRENT OASIS-7: Doubling clopidogrel dosing has ‘favorable net clinical benefit’ Posted: 31 Aug 2009 05:00 PM PDT Doubling the loading and maintenance doses of clopidogrel in the week before percutaneous coronary intervention significantly improves outcomes in patients with acute coronary syndromes, data from the large-scale CURRENT OASIS-7 study show.

AAA study finds no benefit of aspirin in asymptomatic atherosclerosis Posted: 31 Aug 2009 05:00 PM PDT Chronic use of low-dose aspirin does not prevent vascular events in people with asymptomatic atherosclerotic disease detected using the ankle brachial index, study findings show.

“Spot sign” scoring system predicts hematoma expansion in ICH Posted: 31 Aug 2009 05:00 PM PDT A new scoring system that incorporates the "spot sign" on computed tomography angiography is useful for identifying patients with intracerebral hemorrhage who are at high risk for hematoma expansion.

Binge-drinking increases risk of fatal stroke Posted: 31 Aug 2009 05:00 PM PDT Binge-drinking is associated with around a three-fold increased risk of fatal hemorrhagic stroke, a study of Korean men has found.

RE-LY: Dabigatran lowers stroke risk versus warfarin in AF patients Posted: 31 Aug 2009 05:00 PM PDT Treatment with dabigatran significantly reduces stroke risk in comparison with warfarin in patients with atrial fibrillation and at least one risk factor, results of the Randomized Evaluation of Long-term anticoagulant therapY trial show.

AAA study finds no benefit of aspirin in asymptomatic atherosclerosis Posted: 31 Aug 2009 05:00 PM PDT Chronic use of low-dose aspirin does not prevent vascular events in people with asymptomatic atherosclerotic disease detected using the ankle brachial index, study findings show.

Glutamate dysfunction linked to reduced cortical gray matter volume in psychosis Posted: 31 Aug 2009 05:00 PM PDT Individuals at ultra-high risk for developing psychosis have dysfunctional cortical and thalamic glutamate function, which are associated with reductions in cortical gray matter volumes though to be critical to the pathogenesis of the disorder, suggest study results.

G72 gene variation linked to temporal, amygdala gray matter reductions in BD Posted: 31 Aug 2009 05:00 PM PDT Study results show that genetic variation at the M23 single nucleotide polymorphism of the gene encoding G72 is associated with temporal pole and amygdala gray matter reductions in patients with bipolar disorder.

Racial disparity decreasing in US prostate cancer patients Posted: 31 Aug 2009 05:00 PM PDT The disparity in cancer stage at diagnosis between Black and White US prostate cancer patients has significantly narrowed over time, according to US research findings.

Patient involvement affects mastectomy decision Posted: 31 Aug 2009 05:00 PM PDT Women diagnosed with non-metastatic breast cancer who are concerned about body image and their spouse's opinion are less likely to have a mastectomy than those who place less concern on these issues, study findings indicate.

Lipid control in high-risk CAD patients ‘improved but not satisfactory’ Posted: 31 Aug 2009 05:00 PM PDT Therapeutic control of lipid levels in patients with high-risk coronary artery disease is improving but remains suboptimal, a German survey suggests.

Nevirapine boosts HDL cholesterol via apoA-I production Posted: 31 Aug 2009 05:00 PM PDT The antiretroviral drug nevirapine raises high-density lipoprotein cholesterol levels by augmenting apolipoprotein A-I production, research demonstrates.

Atorvastatin improves cardiometabolic risk factors in people with prediabetes Posted: 31 Aug 2009 05:00 PM PDT Researchers reveal a novel pleiotropic effect for atorvastatin in patients with Type 2 diabetes, demonstrating an increase in circulating levels of a splice variant of the soluble form of the receptor for advanced glycation end-products.

Rosiglitazone improves arterial stiffness in Type 2 diabetes Posted: 31 Aug 2009 05:00 PM PDT Treatment with rosiglitazone has a more favorable impact on arterial stiffness than metformin in people with Type 2 diabetes, a small clinical study suggests.

GISSI-HF: Rosuvastatin may reduce new-onset AF in HF patients Posted: 31 Aug 2009 05:00 PM PDT Rosuvastatin therapy may be associated with a reduced incidence of new-onset atrial fibrillation in patients with heart failure, a post hoc analysis of the GISSI-HF trial has demonstrated.

B-CONVINCED: No need to interrupt beta-blockers in acutely decompensated HF Posted: 31 Aug 2009 05:00 PM PDT The results of a major clinical trial support the strategy of continuing beta-blocker therapy in patients who are hospitalized for acutely decompensated heart failure.

RE-LY: Dabigatran lowers stroke risk versus warfarin in AF patients Posted: 31 Aug 2009 05:00 PM PDT Treatment with dabigatran significantly reduces stroke risk in comparison with warfarin in patients with atrial fibrillation and at least one risk factor, results of the Randomized Evaluation of Long-term anticoagulant therapY trial show.

PLATO: Ticagrelor beats clopidogrel in ACS Posted: 31 Aug 2009 05:00 PM PDT The novel antiplatelet therapy ticagrelor reduces the rate of cardiovascular events and death compared with clopidogrel treatment in patients with acute coronary syndrome, without any increase in major bleeding events, the PLATO trial results indicate.

CURRENT OASIS-7: Doubling clopidogrel dosing has ‘favorable net clinical benefit’ Posted: 31 Aug 2009 05:00 PM PDT Doubling the loading and maintenance doses of clopidogrel in the week before percutaneous coronary intervention significantly improves outcomes in patients with acute coronary syndromes, data from the large-scale CURRENT OASIS-7 study show.

AAA study finds no benefit of aspirin in asymptomatic atherosclerosis Posted: 31 Aug 2009 05:00 PM PDT Chronic use of low-dose aspirin does not prevent vascular events in people with asymptomatic atherosclerotic disease detected using the ankle brachial index, study findings show.

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