Medical News

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• Brain-derived neurotrophic factor may account for blunted beta-agonist effect
• Tiotropium not linked to cardiovascular events in COPD patients
• Flu vaccination rates low in Spanish bronchitis patients
• Neuroplasticity-based cognitive training raises BDNF levels in schizophrenia
• Abnormal neural changes with impulsivity in bipolar disorder
• Biomarkers predict VTE risk in cancer patients
• RE-LY substudy: Dabigatran benefits unaffected by prior vitamin K antagonists use or nonuse
• Endarterectomy offers durable benefits in carotid artery stenosis
• Black prostate cancer patients ‘face increased recurrence risk after surgery’
• Black prostate cancer patients ‘face increased recurrence risk after surgery’
• Hypofractionated and normofractionated radiotherapy equal for elderly breast cancer
• Lipid-lowering combinations ‘not supported by evidence’
• Off-label anti-obesity drug use increasing in children
• Rosiglitazone increases risk for new-onset heart failure
• Amylin analog as effective as insulin analog in third-line diabetes treatment
• Glycemic control better if glimepiride continued when switching to insulin
• Rosiglitazone increases risk for new-onset heart failure
• MADIT-CRT shows that resynchronization benefits patients with mild HF
• ACTIVE: Irbesartan in AF fails to lower CV risk overall but reduces HF hospitalization
• PROTECT: Rolofylline fails to improve outcomes in acute heart failure
• Valsartan morbidity and mortality benefits seen in KYOTO HEART Study
• Elevated atmospheric CO linked to CVD hospitalizations in elderly
• Delayed and immediate intervention comparable in NSTE-ACS
• Hypofractionated and normofractionated radiotherapy equal for elderly breast cancer
• Obesity impact on prostate cancer varies with ethnicity
• Prostate cancer screening in the USA may cause overdiagnosis
• Mastectomy rates increasing at Mayo Clinic
• Racial disparity decreasing in US prostate cancer patients
• Patient involvement affects mastectomy decision

Brain-derived neurotrophic factor may account for blunted beta-agonist effect Posted: 03 Sep 2009 05:00 PM PDT Salmeterol monotherapy is associated with significantly increased levels of brain-derived neurotrophic factor, which may account for loss of asthma control in some patients who regularly take β2-agonists, say researchers.

Tiotropium not linked to cardiovascular events in COPD patients Posted: 03 Sep 2009 05:00 PM PDT The use of tiotropium in patients with chronic obstructive pulmonary disease is not associated with an increased relative risk for major cardiovascular events, results of a meta-analysis show.

Flu vaccination rates low in Spanish bronchitis patients Posted: 03 Sep 2009 05:00 PM PDT More than a third of Spanish patients with chronic bronchitis are not being vaccinated against influenza, say researchers who call for measures to improve vaccination rates among this vulnerable group.

Neuroplasticity-based cognitive training raises BDNF levels in schizophrenia Posted: 03 Sep 2009 05:00 PM PDT Neuroplasticity-based cognitive training increases serum brain-derived neurotrophic factor levels in clinically stable, chronically ill schizophrenia patients, US scientists have discovered.

Abnormal neural changes with impulsivity in bipolar disorder Posted: 03 Sep 2009 05:00 PM PDT Impulsivity is associated with abnormal patterns of neural changes in bipolar disorder patients, with the anterior cingulate cortex potentially involved in altered impulsivity regulation, research shows.

Biomarkers predict VTE risk in cancer patients Posted: 02 Sep 2009 05:00 PM PDT The Vienna Cancer and Thrombosis study shows that venous thromboembolism can be predicted in cancer patients using levels of D-dimer and prothrombin fragment 1+2.

RE-LY substudy: Dabigatran benefits unaffected by prior vitamin K antagonists use or nonuse Posted: 02 Sep 2009 05:00 PM PDT The effects of dabigatran are similar in patients with atrial fibrillation who have and have not previously taken vitamin K antagonists, indicate data from the RE-LY trial.

Endarterectomy offers durable benefits in carotid artery stenosis Posted: 02 Sep 2009 05:00 PM PDT Carotid endarterectomy should be the treatment of choice in patients with symptomatic carotid artery stenosis, long-term clinical trial data indicate.

Black prostate cancer patients ‘face increased recurrence risk after surgery’ Posted: 02 Sep 2009 05:00 PM PDT Black men are significantly more likely than White men to experience an increase in their risk for biochemical recurrence after undergoing radical prostatectomy for prostate cancer, US study findings suggest.

Black prostate cancer patients ‘face increased recurrence risk after surgery’ Posted: 02 Sep 2009 05:00 PM PDT Black men are significantly more likely than White men to experience an increase in their risk for biochemical recurrence after undergoing radical prostatectomy for prostate cancer, US study findings suggest.

Hypofractionated and normofractionated radiotherapy equal for elderly breast cancer Posted: 02 Sep 2009 05:00 PM PDT Treatment with hypofractionated radiotherapy may be an acceptable alternative to normofractionated radiotherapy in elderly patients with breast cancer, according to French researchers.

Lipid-lowering combinations ‘not supported by evidence’ Posted: 02 Sep 2009 05:00 PM PDT There is insufficient evidence to recommend combinations of lipid-lowering agents over high-dose statin monotherapy, a systematic review suggests.

Off-label anti-obesity drug use increasing in children Posted: 02 Sep 2009 05:00 PM PDT Off-label prescribing of anti-obesity drugs to children is becoming increasingly common, say researchers who suggest that such drugs are poorly tolerated or lack efficacy in this population.

Rosiglitazone increases risk for new-onset heart failure Posted: 02 Sep 2009 05:00 PM PDT The anti-diabetes drug rosiglitazone is associated with an increased risk for new-onset heart failure but no increase in acute coronary events as compared with traditional glucose-lowering drugs, post hoc analyses of the RECORD trial indicate.

Amylin analog as effective as insulin analog in third-line diabetes treatment Posted: 02 Sep 2009 05:00 PM PDT Taking the amylin analog pramlintide before meals is as effective as taking a rapid-acting insulin analog for glycemic control in individuals with Type 2 diabetes who are already using basal insulin and oral anti-hyperglycemic medications, say clinicians.

Glycemic control better if glimepiride continued when switching to insulin Posted: 02 Sep 2009 05:00 PM PDT Patients with Type 2 diabetes achieve better glycemic control when starting insulin therapy if they continue glimepiride treatment, Japanese researchers report.

Rosiglitazone increases risk for new-onset heart failure Posted: 02 Sep 2009 05:00 PM PDT The anti-diabetes drug rosiglitazone is associated with an increased risk for new-onset heart failure but no increase in acute coronary events as compared with traditional glucose-lowering drugs, post hoc analyses of the RECORD trial indicate.

MADIT-CRT shows that resynchronization benefits patients with mild HF Posted: 02 Sep 2009 05:00 PM PDT Results of the MADIT-CRT trial show that the use of cardiac resynchronization therapy combined with defibrillation reduces heart failure events in comparison with the use of an implantable cardioverter defibrillator alone in patients with relatively mild heart failure.

ACTIVE: Irbesartan in AF fails to lower CV risk overall but reduces HF hospitalization Posted: 02 Sep 2009 05:00 PM PDT Treatment with the angiotensin receptor blocker irbesartan failed to reduce the risk for cardiovascular death, myocardial infarction, or stroke in patients with atrial fibrillation, but did reduce heart failure hospitalizations, ACTIVE I trial findings reveal.

PROTECT: Rolofylline fails to improve outcomes in acute heart failure Posted: 02 Sep 2009 05:00 PM PDT Rolofylline, a selective, A1 adenosine receptor antagonist, does not improve overall outcomes in patients with acutely decompensated heart failure, a phase III clinical trial has shown.

Valsartan morbidity and mortality benefits seen in KYOTO HEART Study Posted: 02 Sep 2009 05:00 PM PDT Valsartan added to conventional antihypertensive treatment significantly improves cardiovascular outcomes in high risk Japanese patients, an effect that is primarily driven by reductions in stroke and angina, say researchers.

Elevated atmospheric CO linked to CVD hospitalizations in elderly Posted: 02 Sep 2009 05:00 PM PDT A rise in atmospheric carbon monoxide of just 1 part per million triggers an almost 1% increase in the rate of cardiovascular disease admissions among elderly individuals, study results demonstrate.

Delayed and immediate intervention comparable in NSTE-ACS Posted: 02 Sep 2009 05:00 PM PDT Delaying catheterization in patients with acute coronary syndromes without ST-segment elevation does not adversely impact clinical outcomes, results of a study suggest.

Hypofractionated and normofractionated radiotherapy equal for elderly breast cancer Posted: 02 Sep 2009 05:00 PM PDT Treatment with hypofractionated radiotherapy may be an acceptable alternative to normofractionated radiotherapy in elderly patients with breast cancer, according to French researchers.

Obesity impact on prostate cancer varies with ethnicity Posted: 01 Sep 2009 05:00 PM PDT Body mass and weight gain in adulthood affects a man's future risk for prostate cancer, according to a study undertaken using a multi-racial cohort.

Prostate cancer screening in the USA may cause overdiagnosis Posted: 01 Sep 2009 05:00 PM PDT The introduction of prostate-specific antigen screening for prostate cancer in the USA has resulted in an estimated 1 million additional men being diagnosed and treated for the disease since 1986 than would otherwise have occurred, US study findings report.

Mastectomy rates increasing at Mayo Clinic Posted: 01 Sep 2009 05:00 PM PDT Mastectomy rates have increased in recent years with both surgery year and magnetic resonance imaging significantly predicting this type of surgery, US researchers report.

Racial disparity decreasing in US prostate cancer patients Posted: 31 Aug 2009 05:00 PM PDT The disparity in cancer stage at diagnosis between Black and White US prostate cancer patients has significantly narrowed over time, according to US research findings.

Patient involvement affects mastectomy decision Posted: 31 Aug 2009 05:00 PM PDT Women diagnosed with non-metastatic breast cancer who are concerned about body image and their spouse's opinion are less likely to have a mastectomy than those who place less concern on these issues, study findings indicate.

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