Medical News

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• Counseling and NRT best for smoking cessation in COPD patients
• Passive smoking in cars linked to hayfever and wheezing in children
• Conjugated vaccine may offer improved pneumonia protection for COPD patients
• Prenatal infection and family history synergistically raise schizophrenia risk
• BDNF levels ‘normalized’ in euthymic bipolar disorder patients
• Variant alleles confer increased risk for VTE in elderly
• ABCD² score aids differential diagnosis
• Prostate cancer risk appreciable even after two negative biopsies
• Prostate cancer detection and aggressiveness raised in smaller prostates
• Securin immunopositivity predicts poor breast cancer outcome
• Aspirin and intensive exercise eliminate HRT colorectal cancer benefits
• Intraocular pressure in postmenopausal women unrelated to estradiol levels
• Immune reactions allow ovarian cancer detection and differentiation
• Quality of life issues in ovarian cancer chemotherapy ‘treatable’
• Altered HOXA-10 expression may explain female infertility
• Infertile women ‘generally satisfied with fertility care experience’
• Conception with intrauterine device increases adverse pregnancy outcomes
• Less than half of infertile women seek treatment
• Interleukin-6 levels increased in women with unexplained infertility
• Defective mitochondrial replacement in embryos ‘on the horizon’
• Normal weight obesity syndrome increases risk for cardiovascular disease
• Leptin improves lipids and glycemic control in lipodystrophy patients
• Normal weight obesity syndrome increases risk for cardiovascular disease
• Darusentan provides additional BP lowering in resistant hypertension
• Dapagliflozin useful third-line therapy for Type 2 diabetes
• Macular edema prevalence varies by ethnicity
• Leptin improves lipids and glycemic control in lipodystrophy patients
• Clinical factors predict post-MI gastrointestinal bleeding risk
• Darusentan provides additional BP lowering in resistant hypertension

Counseling and NRT best for smoking cessation in COPD patients Posted: 14 Sep 2009 05:00 PM PDT Counseling combined with nicotine replacement therapy is the most effective smoking cessation intervention for patients with chronic obstructive pulmonary disease, findings from a meta-analysis suggest.

Passive smoking in cars linked to hayfever and wheezing in children Posted: 14 Sep 2009 05:00 PM PDT Children who are regularly exposed to second-hand tobacco smoke when traveling by car have significantly higher rates of hayfever and wheezing than those without such exposure, results of an Irish study show.

Conjugated vaccine may offer improved pneumonia protection for COPD patients Posted: 14 Sep 2009 05:00 PM PDT A novel conjugated vaccine against pneumonia may offer better protection for chronic obstructive pulmonary disease patients than the currently available vaccine, claim researchers.

Prenatal infection and family history synergistically raise schizophrenia risk Posted: 14 Sep 2009 05:00 PM PDT Prenatal exposure to infection appears to work synergistically with a family history of psychosis to increase the risk for developing schizophrenia in later life, a team of European researchers has discovered.

BDNF levels ‘normalized’ in euthymic bipolar disorder patients Posted: 14 Sep 2009 05:00 PM PDT Euthymic bipolar disorder patients have similar serum brain-derived neurotrophic factor levels to those of healthy individuals, supporting the theory that treatment normalizes levels of the neurotrophin, say scientists.

Variant alleles confer increased risk for VTE in elderly Posted: 13 Sep 2009 05:00 PM PDT Variants coagulation genes may contribute to the increased risk for venous thromboembolism found in older individuals, US researchers suggest.

ABCD<sup>2</sup> score aids differential diagnosis Posted: 13 Sep 2009 05:00 PM PDT The ABCD2 score, used in clinical practice to predict stroke risk following transient ischemic attack, is also helpful for distinguishing cerebrovascular from noncerebrovascular events in patients with transient neurologic symptoms.

Prostate cancer risk appreciable even after two negative biopsies Posted: 13 Sep 2009 05:00 PM PDT Approximately a quarter of patients with at least two sets of negative prostate biopsies remain at increased risk for prostate cancer, and the majority of tumors detected are clinically significant, the results of a French study indicate.

Prostate cancer detection and aggressiveness raised in smaller prostates Posted: 13 Sep 2009 05:00 PM PDT Men with small prostate volumes and high initial prostate-specific antigen levels have a greater risk for cancer detection and aggressive disease than other men, Dutch researchers have discovered.

Securin immunopositivity predicts poor breast cancer outcome Posted: 13 Sep 2009 05:00 PM PDT Securin immunopositivity is an independent prognostic indicator for invasive breast cancer, Finnish research suggests.

Aspirin and intensive exercise eliminate HRT colorectal cancer benefits Posted: 13 Sep 2009 05:00 PM PDT The beneficial effects of HRT on the risk for colorectal cancer are eliminated by aspirin use and intensive physical activity, report investigators.

Intraocular pressure in postmenopausal women unrelated to estradiol levels Posted: 13 Sep 2009 05:00 PM PDT Intraocular pressure does not appear to be associated with serum estradiol concentrations in postmenopausal women, conclude Korean researchers.

Immune reactions allow ovarian cancer detection and differentiation Posted: 13 Sep 2009 05:00 PM PDT Circulating levels of tumor reactive immunoglobulin G can detect the presence of ovarian cancer, with specific antigens also allowing early and late stage disease to be differentiated, the results of a US study indicate.

Quality of life issues in ovarian cancer chemotherapy ‘treatable’ Posted: 13 Sep 2009 05:00 PM PDT Many of the quality of life issues experienced by women undergoing chemotherapy for ovarian cancer may be addressed using symptom management and psychosocial support, US study findings indicate.

Altered HOXA-10 expression may explain female infertility Posted: 13 Sep 2009 05:00 PM PDT Female infertility may partly be due to altered homeobox A10 expression in endometrial stromal cells during the implantation window, particularly in women with superficial peritoneal endometriosis, say French scientists.

Infertile women ‘generally satisfied with fertility care experience’ Posted: 13 Sep 2009 05:00 PM PDT Infertile women are generally satisfied with their experience of fertility care, but the least positive aspects of care are waiting times, information provision, and emotional support, Dutch scientists have discovered.

Conception with intrauterine device increases adverse pregnancy outcomes Posted: 13 Sep 2009 05:00 PM PDT Women who conceive when using an intrauterine contraceptive device have an increased risk for adverse obstetric outcomes compared with other women, but the risk is reduced with early device removal, conclude Israeli researchers.

Less than half of infertile women seek treatment Posted: 13 Sep 2009 05:00 PM PDT Just half of infertile women use hormonal and/or IVF treatment, with those diagnosed with polycystic ovary syndrome and endometriosis the most proactive in seeking advice and treatment, an Australian study concludes.

Interleukin-6 levels increased in women with unexplained infertility Posted: 13 Sep 2009 05:00 PM PDT Women with unexplained infertility have increased serum levels of the inflammatory cytokine interleukin-6 in comparison with fertile women, Turkish investigators have discovered.

Defective mitochondrial replacement in embryos ‘on the horizon’ Posted: 13 Sep 2009 05:00 PM PDT Embryos for IVF carrying mitochondrial gene defects may eventually be able to have the defects corrected replaced after researchers replaced the mitochrondrial genome in monkey embryos, resulting in healthy births.

Normal weight obesity syndrome increases risk for cardiovascular disease Posted: 13 Sep 2009 05:00 PM PDT Normal weight obesity syndrome is associated with increased risk for dyslipidemia, hypertension, and hyperglycemia, report researchers.

Leptin improves lipids and glycemic control in lipodystrophy patients Posted: 13 Sep 2009 05:00 PM PDT US researchers have discovered that leptin therapy can significantly improve the symptoms of patients with different forms of lipodystrophy.

Normal weight obesity syndrome increases risk for cardiovascular disease Posted: 13 Sep 2009 05:00 PM PDT Normal weight obesity syndrome is associated with increased risk for dyslipidemia, hypertension, and hyperglycemia, report researchers.

Darusentan provides additional BP lowering in resistant hypertension Posted: 13 Sep 2009 05:00 PM PDT The selective endothelin receptor antagonist darusentan lowers blood pressure levels in patients with hypertension who are failing to reach treatment goals with established antihypertensive drugs, study findings published in The Lancet show.

Dapagliflozin useful third-line therapy for Type 2 diabetes Posted: 13 Sep 2009 05:00 PM PDT The sodium–glucose co-transporter 2 inhibitor dapagliflozin stimulates further improvements in glycated hemoglobin and weight loss in patients with Type 2 diabetes when added to a regimen of insulin and insulin-sensitizing drugs, research shows.

Macular edema prevalence varies by ethnicity Posted: 13 Sep 2009 05:00 PM PDT Subanalysis of the Veterans Affairs Diabetes Trial shows that clinically significant macular edema in patients with Type 2 diabetes and cardiovascular disease is more common in Hispanic and African–American patients than in non-Hispanic Whites.

Leptin improves lipids and glycemic control in lipodystrophy patients Posted: 13 Sep 2009 05:00 PM PDT US researchers have discovered that leptin therapy can significantly improve the symptoms of patients with different forms of lipodystrophy.

Clinical factors predict post-MI gastrointestinal bleeding risk Posted: 13 Sep 2009 05:00 PM PDT Researchers have identified clinical characteristics that predict risk for gastrointestinal bleeding following a myocardial infarction, data they say could help clinicians to be particularly vigilant when managing patients with multiple such risk factors.

Darusentan provides additional BP lowering in resistant hypertension Posted: 13 Sep 2009 05:00 PM PDT The selective endothelin receptor antagonist darusentan lowers blood pressure levels in patients with hypertension who are failing to reach treatment goals with established antihypertensive drugs, study findings published in The Lancet show.

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