Medical News

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• <i>IL2-21</i> polymorphisms implicated in IBD
• Night-time GERD symptoms linked to sleep problems
• Supragastric belches linked with reflux episodes
• Asthma in childhood increases adult COPD risk
• Study supports systemic inflammation link to reduced lung function
• Improving pulmonary rehabilitation expectations may boost attendance
• TEG results affected by blood acidosis, low temp
• Neuroplasticity-based cognitive training raises BDNF levels in schizophrenia
• Survey highlights large gaps in public knowledge about stroke
• TNF inhibitors more effective than T-cell agents in treating plaque psoriasis
• DNA vaccine encoding PAP shows prostate cancer treatment promise
• Genetic risk variants for prostate cancer differ across populations
• DNA vaccine encoding PAP shows prostate cancer treatment promise
• Genetic risk variants for prostate cancer differ across populations
• Clinical breast exams increase breast screening false positives
• TGR5 activation a promising new approach to 'diabesity'
• Characteristic lipid patterns drive vascular risk in CAD
• Low para-oxonase-1 activity ‘not a causal factor’ in atherosclerosis
• Natriuretic peptides ‘the only useful HF markers’ in emergency setting
• TGR5 activation a promising new approach to 'diabesity'
• Exenatide of benefit in insulin-treated Type 2 diabetes patients
• Natriuretic peptides ‘the only useful HF markers’ in emergency setting
• Survival benefit of LV assist devices in cardiogenic shock questioned
• Clinical breast exams increase breast screening false positives
• Abnormal neural changes with impulsivity in bipolar disorder
• Negative symptoms key to schizophrenia neurocognition–function link
• Valsartan morbidity and mortality benefits seen in KYOTO HEART Study
• Rosiglitazone increases risk for new-onset heart failure
• MADIT-CRT shows that resynchronization benefits patients with mild HF
• PROTECT: Rolofylline fails to improve outcomes in acute heart failure
• Cardiovascular disease and hypertension risk increased in bipolar I disorder
• Reduced life satisfaction forms key aspect of stigma experience in schizophrenia
• High BMI linked to poor outcome in bipolar disorder
• Glutamate dysfunction linked to reduced cortical gray matter volume in psychosis
• GISSI-HF: Rosuvastatin may reduce new-onset AF in HF patients
• B-CONVINCED: No need to interrupt beta-blockers in acutely decompensated HF
• G72 gene variation linked to temporal, amygdala gray matter reductions in BD

<i>IL2-21</i> polymorphisms implicated in IBD Posted: 06 Sep 2009 05:00 PM PDT Genetic variants in the interleukin 2-to-21 region may be linked to inflammatory bowel disease, a study of Spanish patients has revealed.

Night-time GERD symptoms linked to sleep problems Posted: 06 Sep 2009 05:00 PM PDT Symptoms of gastroesophageal reflux disease at night are associated with trouble falling and staying asleep, US research suggests.

Supragastric belches linked with reflux episodes Posted: 06 Sep 2009 05:00 PM PDT Supragastric belches occur more frequently among people with reflux symptoms than in others, a study indicates.

Asthma in childhood increases adult COPD risk Posted: 05 Sep 2009 05:00 PM PDT A parental history of asthma, childhood asthma, maternal smoking and childhood respiratory infections are associated with an increased risk for chronic obstructive pulmonary disease in adulthood, study results show.

Study supports systemic inflammation link to reduced lung function Posted: 05 Sep 2009 05:00 PM PDT Results of an Icelandic study confirm that there is a significant association between systemic inflammation and reduced lung function.

Improving pulmonary rehabilitation expectations may boost attendance Posted: 05 Sep 2009 05:00 PM PDT Improving lung disease patients' perceptions about the effectiveness of pulmonary rehabilitation may help improve attendance and reduce drop-out rates, say researchers.

TEG results affected by blood acidosis, low temp Posted: 03 Sep 2009 05:00 PM PDT Hemostasis testing should take into account patient physiologic factors, say scientists who found that thromboelastography results are affected by blood pH and temperature.

Neuroplasticity-based cognitive training raises BDNF levels in schizophrenia Posted: 03 Sep 2009 05:00 PM PDT Neuroplasticity-based cognitive training increases serum brain-derived neurotrophic factor levels in clinically stable, chronically ill schizophrenia patients, US scientists have discovered.

Survey highlights large gaps in public knowledge about stroke Posted: 03 Sep 2009 05:00 PM PDT Public knowledge of the signs, symptoms, and risk factors for stroke is "inadequate" or "moderate" at best, a survey of the French general population indicates.

TNF inhibitors more effective than T-cell agents in treating plaque psoriasis Posted: 03 Sep 2009 05:00 PM PDT Tumor necrosis factor inhibitors are more effective than T-cell agents for the treatment of moderate-to-severe plaque psoriasis, results of a systematic review and meta analysis indicate.

DNA vaccine encoding PAP shows prostate cancer treatment promise Posted: 03 Sep 2009 05:00 PM PDT Prostate cancer may eventually be treatable with a DNA vaccine encoding prostatic acid phosphatase, after US researchers found that it elicits an antigen-specific T cell response and increases prostate-specific antigen doubling time.

Genetic risk variants for prostate cancer differ across populations Posted: 03 Sep 2009 05:00 PM PDT Single-nucleotide polymorphisms associated with a risk for prostate cancer in men of European ancestry have a different prognostic significance in Japanese men, say international researchers.

DNA vaccine encoding PAP shows prostate cancer treatment promise Posted: 03 Sep 2009 05:00 PM PDT Prostate cancer may eventually be treatable with a DNA vaccine encoding prostatic acid phosphatase, after US researchers found that it elicits an antigen-specific T cell response and increases prostate-specific antigen doubling time.

Genetic risk variants for prostate cancer differ across populations Posted: 03 Sep 2009 05:00 PM PDT Single-nucleotide polymorphisms associated with a risk for prostate cancer in men of European ancestry have a different prognostic significance in Japanese men, say international researchers.

Clinical breast exams increase breast screening false positives Posted: 03 Sep 2009 05:00 PM PDT Adding clinical breast examination to mammography increases breast cancer detection rates and referral sensitivity at the cost of decreased specificity, Canadian study data shows.

TGR5 activation a promising new approach to 'diabesity' Posted: 03 Sep 2009 05:00 PM PDT TGR5, a G protein-coupled receptor expressed in brown adipose tissue and muscle, may be a novel therapeutic target for Type 2 diabetes and obesity or "diabesity," research indicates.

Characteristic lipid patterns drive vascular risk in CAD Posted: 03 Sep 2009 05:00 PM PDT An international team of researchers has identified a characteristic pattern of lipid and lipoprotein abnormalities which they believe drives vascular risk in statin-treated patients with coronary artery disease.

Low para-oxonase-1 activity ‘not a causal factor’ in atherosclerosis Posted: 03 Sep 2009 05:00 PM PDT A large case–control study suggests that low para-oxonase-1 enzyme activity does not cause atherogenesis.

Natriuretic peptides ‘the only useful HF markers’ in emergency setting Posted: 03 Sep 2009 05:00 PM PDT The only current useful diagnostic markers of heart failure in the emergency setting are B-type natriuretic peptide and midregional pro-A-type natriuretic peptide, study results show.

TGR5 activation a promising new approach to 'diabesity' Posted: 03 Sep 2009 05:00 PM PDT TGR5, a G protein-coupled receptor expressed in brown adipose tissue and muscle, may be a novel therapeutic target for Type 2 diabetes and obesity or "diabesity," research indicates.

Exenatide of benefit in insulin-treated Type 2 diabetes patients Posted: 03 Sep 2009 05:00 PM PDT The addition of exenatide to insulin-based therapy is associated with improved glycemic control, less weight gain, and reduced prandial insulin requirements for treatment periods of up to 27 months, researchers report.

Natriuretic peptides ‘the only useful HF markers’ in emergency setting Posted: 03 Sep 2009 05:00 PM PDT The only current useful diagnostic markers of heart failure in the emergency setting are B-type natriuretic peptide and midregional pro-A-type natriuretic peptide, study results show.

Survival benefit of LV assist devices in cardiogenic shock questioned Posted: 03 Sep 2009 05:00 PM PDT Left ventricular assist devices improve hemodynamic profile in patients with cardiogenic shock, but provide no extra survival benefit over intra-aortic balloon pumps, results of a meta-analysis demonstrate.

Clinical breast exams increase breast screening false positives Posted: 03 Sep 2009 05:00 PM PDT Adding clinical breast examination to mammography increases breast cancer detection rates and referral sensitivity at the cost of decreased specificity, Canadian study data shows.

Abnormal neural changes with impulsivity in bipolar disorder Posted: 03 Sep 2009 05:00 PM PDT Impulsivity is associated with abnormal patterns of neural changes in bipolar disorder patients, with the anterior cingulate cortex potentially involved in altered impulsivity regulation, research shows.

Negative symptoms key to schizophrenia neurocognition–function link Posted: 02 Sep 2009 05:00 PM PDT Negative symptoms may partly mediate the relationship between neurocognition and functional outcome in schizophrenia, despite also being a predictor of outcome, the results of a study indicate.

Valsartan morbidity and mortality benefits seen in KYOTO HEART Study Posted: 02 Sep 2009 05:00 PM PDT Valsartan added to conventional antihypertensive treatment significantly improves cardiovascular outcomes in high risk Japanese patients, an effect that is primarily driven by reductions in stroke and angina, say researchers.

Rosiglitazone increases risk for new-onset heart failure Posted: 02 Sep 2009 05:00 PM PDT The anti-diabetes drug rosiglitazone is associated with an increased risk for new-onset heart failure but no increase in acute coronary events as compared with traditional glucose-lowering drugs, post hoc analyses of the RECORD trial indicate.

MADIT-CRT shows that resynchronization benefits patients with mild HF Posted: 02 Sep 2009 05:00 PM PDT Results of the MADIT-CRT trial show that the use of cardiac resynchronization therapy combined with defibrillation reduces heart failure events in comparison with the use of an implantable cardioverter defibrillator alone in patients with relatively mild heart failure.

PROTECT: Rolofylline fails to improve outcomes in acute heart failure Posted: 02 Sep 2009 05:00 PM PDT Rolofylline, a selective, A1 adenosine receptor antagonist, does not improve overall outcomes in patients with acutely decompensated heart failure, a phase III clinical trial has shown.

Cardiovascular disease and hypertension risk increased in bipolar I disorder Posted: 02 Sep 2009 05:00 PM PDT Adults with bipolar I disorder are at increased risk for cardiovascular disease and hypertension, which occur over a decade earlier than in adults without the disorder, researchers have discovered.

Reduced life satisfaction forms key aspect of stigma experience in schizophrenia Posted: 01 Sep 2009 05:00 PM PDT The extent of stigma experienced by patients diagnosed with schizophrenia may be relatively independent of disease severity, with reduced life satisfaction forming a key aspect of the subjective experience of stigma, suggest study results.

High BMI linked to poor outcome in bipolar disorder Posted: 01 Sep 2009 05:00 PM PDT Bipolar disorder patients with elevated body mass index are more likely to experience a more severe disease course in terms of chronicity, duration of illness, and overall functioning, suggest study results.

Glutamate dysfunction linked to reduced cortical gray matter volume in psychosis Posted: 31 Aug 2009 05:00 PM PDT Individuals at ultra-high risk for developing psychosis have dysfunctional cortical and thalamic glutamate function, which are associated with reductions in cortical gray matter volumes though to be critical to the pathogenesis of the disorder, suggest study results.

GISSI-HF: Rosuvastatin may reduce new-onset AF in HF patients Posted: 31 Aug 2009 05:00 PM PDT Rosuvastatin therapy may be associated with a reduced incidence of new-onset atrial fibrillation in patients with heart failure, a post hoc analysis of the GISSI-HF trial has demonstrated.

B-CONVINCED: No need to interrupt beta-blockers in acutely decompensated HF Posted: 31 Aug 2009 05:00 PM PDT The results of a major clinical trial support the strategy of continuing beta-blocker therapy in patients who are hospitalized for acutely decompensated heart failure.

G72 gene variation linked to temporal, amygdala gray matter reductions in BD Posted: 31 Aug 2009 05:00 PM PDT Study results show that genetic variation at the M23 single nucleotide polymorphism of the gene encoding G72 is associated with temporal pole and amygdala gray matter reductions in patients with bipolar disorder.

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