Medical News

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• Hyaluronic acid dsyregulation implicated in COPD, asthma
• GINA definition of airflow obstruction ‘should be changed’
• Gene variants linked to chronic bronchitis in COPD
• PTSD increases suicide risk, worsens outcome in BD
• Gray matter abnormalities differ in early, late psychosis vulnerability states
• rFVIIa reduces postoperative bleeding
• Diabetes linked to brain atrophy, increased cerebral infarct risk
• Men have worse prognosis after ICH than women
• High burden of acute exacerbation found in COPD with AATD
• Depression prevalent in COPD, linked to disease severity
• MCP-1 predicts COPD in heavy smokers
• Neurological signs in adolescent psychosis point to brain structure defects
• Brain volume changes in bipolar disorder linked to age and illness duration
• Rare prostate stem cells may be linked to cancer formation
• Soy isoflavone supplements may help prevent prostate cancer
• Rare prostate stem cells may be linked to cancer formation
• Adjuvant systemic treatment responsible for reducing breast cancer metastases risk
• Soy isoflavone supplements may help prevent prostate cancer
• Protein modifies HDL into pro-inflammatory particle
• Statin decreases myocardial ischemia risk after vascular surgery
• Diabetes linked to brain atrophy, increased cerebral infarct risk
• Coffee and tea consumption reduces the risk for Type 2 diabetes
• SYNTAX 2-year data suggest CABG pulling ahead of PCI
• Meta-analysis finds manual thrombectomy in PCI for STEMI improves survival
• Adjuvant systemic treatment responsible for reducing breast cancer metastases risk
• Postoperative therapies may improve prostate cancer relapse rates
• <i>PNPLA3</i> variant linked to NAFLD
• Metabolic syndrome linked to PAD risk in women
• Pulmonary delivery promising route for GLP-1 administration
• Molecular mechanism underlying form of neonatal diabetes revealed
• Peri-procedural myocardial necrosis may be worse with CABG than PCI
• Depression severity, persistence linked to increased post-ACS mortality
• Seroma volume decreases during WBRT
• BMI and prostate weight indicate increased blood loss in prostate surgery
• Obesity associated with aggressive prostate cancer
• SLN procedure has not led to breast cancer stage migration
• Prostate cancer treatment preferences affected by information sources
• Confirmatory tumor biopsy may alter metastatic breast cancer management

Hyaluronic acid dsyregulation implicated in COPD, asthma Posted: 10 Sep 2009 05:00 PM PDT Abnormalities in hyaluronic acid, a component of the extracellular matrix, may be involved in the pathogenesis of asthma and chronic obstructive pulmonary disease, in vitro research indicates.

GINA definition of airflow obstruction ‘should be changed’ Posted: 10 Sep 2009 05:00 PM PDT The fixed FEV1/FVC cutpoint used to define airflow obstruction by the Global Initiative for Asthma causes confusion and should be changed, experts believe.

Gene variants linked to chronic bronchitis in COPD Posted: 10 Sep 2009 05:00 PM PDT Several polymorphisms in the gene encoding cytotoxic T-lymphocyte antigen 4 appear to be associated with the presence of chronic bronchitis in chronic obstructive pulmonary disease, study results show.

PTSD increases suicide risk, worsens outcome in BD Posted: 10 Sep 2009 05:00 PM PDT Study results suggest that bipolar patients have a poorer outcome if they have comorbid post-traumatic stress disorder, with a lower likelihood of recovery, increase in rapid cycling periods and suicide attempts, and an overall worse quality of life.

Gray matter abnormalities differ in early, late psychosis vulnerability states Posted: 10 Sep 2009 05:00 PM PDT Structural brain abnormalities linked to an "early" at-risk mental state may dictate an elevated susceptibility to psychosis, while those seen during a "late" state may indicate a subsequent transition to psychosis, suggest study results.

rFVIIa reduces postoperative bleeding Posted: 09 Sep 2009 05:00 PM PDT Recombinant activated factor VII may reduce bleeding after cardiac surgery, suggest study findings published in the journal Circulation.

Diabetes linked to brain atrophy, increased cerebral infarct risk Posted: 09 Sep 2009 05:00 PM PDT Elderly people with Type 2 diabetes have more pronounced brain atrophy and are more likely to have cerebral infarcts than their nondiabetic peers, show the results of a large cross-sectional study published in the journal Diabetes Care.

Men have worse prognosis after ICH than women Posted: 09 Sep 2009 05:00 PM PDT Survival after primary intracerebral hemorrhage is lower in men than women, a Swedish study has found.

High burden of acute exacerbation found in COPD with AATD Posted: 09 Sep 2009 05:00 PM PDT The vast majority of patients with chronic obstructive pulmonary disease and concurrent alpha-1 antitrypsin deficiency will experience at least one exacerbation per year, despite augmentation therapy, study findings show.

Depression prevalent in COPD, linked to disease severity Posted: 09 Sep 2009 05:00 PM PDT Around 20% of patients with stable chronic obstructive pulmonary disease have clinical levels of depression, as well as a tendency for poorer exercise capacity and more severe disease, study results show.

MCP-1 predicts COPD in heavy smokers Posted: 09 Sep 2009 05:00 PM PDT The biomarker monocyte chemoattractant protein-1 has emerged as a potentially useful predictor of chronic obstructive pulmonary disease in heavy smokers, study results show.

Neurological signs in adolescent psychosis point to brain structure defects Posted: 09 Sep 2009 05:00 PM PDT Region-specific structural brain deficits in adolescents with first-episode psychosis are associated with the severity of neurological soft signs, potentially providing a marker for such deficits, conclude Spanish scientists.

Brain volume changes in bipolar disorder linked to age and illness duration Posted: 09 Sep 2009 05:00 PM PDT Bipolar disorder patients have significant brain volume changes compared with healthy individuals that are linked to age and duration of illness, but the changes do not appear to be diagnostically specific, say UK researchers.

Rare prostate stem cells may be linked to cancer formation Posted: 09 Sep 2009 05:00 PM PDT A novel luminal prostate stem cell involved in tissue regeneration may be a source of prostate cancer in the presence of inactivated tumor suppressor genes, the results of a mouse study indicate.

Soy isoflavone supplements may help prevent prostate cancer Posted: 09 Sep 2009 05:00 PM PDT A diet based on soy isoflavones may help to prevent the development of prostate cancer in healthy men, Japanese researchers report.

Rare prostate stem cells may be linked to cancer formation Posted: 09 Sep 2009 05:00 PM PDT A novel luminal prostate stem cell involved in tissue regeneration may be a source of prostate cancer in the presence of inactivated tumor suppressor genes, the results of a mouse study indicate.

Adjuvant systemic treatment responsible for reducing breast cancer metastases risk Posted: 09 Sep 2009 05:00 PM PDT Breast cancer tumor size had a greater impact on the risk for distant metastases prior to 1991 than it did between 1991 and 1999, research shows.

Soy isoflavone supplements may help prevent prostate cancer Posted: 09 Sep 2009 05:00 PM PDT A diet based on soy isoflavones may help to prevent the development of prostate cancer in healthy men, Japanese researchers report.

Protein modifies HDL into pro-inflammatory particle Posted: 09 Sep 2009 05:00 PM PDT US research has identified novel ways in which myeloperoxidase modifies high-density lipoprotein to generate a pro-inflammatory particle that could impact on the development of cardiovascular disease.

Statin decreases myocardial ischemia risk after vascular surgery Posted: 09 Sep 2009 05:00 PM PDT Fluvastatin treatment around the time of vascular surgery significantly reduces the risk for postoperative myocardial ischemia compared with placebo, trial findings indicate.

Diabetes linked to brain atrophy, increased cerebral infarct risk Posted: 09 Sep 2009 05:00 PM PDT Elderly people with Type 2 diabetes have more pronounced brain atrophy and are more likely to have cerebral infarcts than their nondiabetic peers, show the results of a large cross-sectional study published in the journal Diabetes Care.

Coffee and tea consumption reduces the risk for Type 2 diabetes Posted: 09 Sep 2009 05:00 PM PDT Drinking a lot of tea and coffee every day is associated with significantly reduced risk for Type 2 diabetes, show study results.

SYNTAX 2-year data suggest CABG pulling ahead of PCI Posted: 09 Sep 2009 05:00 PM PDT Updated SYNTAX results show a continuing reduction in cardiovascular events with coronary artery bypass graft surgery compared with percutaneous coronary intervention in patients with complex coronary artery disease at 2 years of follow-up.

Meta-analysis finds manual thrombectomy in PCI for STEMI improves survival Posted: 09 Sep 2009 05:00 PM PDT Manual, but not mechanical, thrombus aspiration during percutaneous coronary intervention is associated with improved survival at 1 year in ST-elevation myocardial infarction patients, results of a meta-analysis indicate.

Adjuvant systemic treatment responsible for reducing breast cancer metastases risk Posted: 09 Sep 2009 05:00 PM PDT Breast cancer tumor size had a greater impact on the risk for distant metastases prior to 1991 than it did between 1991 and 1999, research shows.

Postoperative therapies may improve prostate cancer relapse rates Posted: 08 Sep 2009 05:00 PM PDT Prostate cancer patients with stage T3 cancer and/or positive surgical margins after radical prostatectomy may have improved relapse rates if they receive additional postoperative therapies, research findings suggest.

<i>PNPLA3</i> variant linked to NAFLD Posted: 08 Sep 2009 05:00 PM PDT A variant of the adiponutrin gene is linked to nonalcoholic fatty liver disease, report researchers in the Journal of Lipid Research.

Metabolic syndrome linked to PAD risk in women Posted: 08 Sep 2009 05:00 PM PDT Presence of the metabolic syndrome increases the risk for peripheral artery disease in women, but this is largely mediated by the effects of inflammation and endothelial activation, say investigators.

Pulmonary delivery promising route for GLP-1 administration Posted: 08 Sep 2009 05:00 PM PDT Administration of glucagon-like peptide-1 by the pulmonary route results in rapid absorption of GLP-1 that promotes insulin secretion and controls postprandial glucose hyperglycemia in a rat model of Type 2 diabetes.

Molecular mechanism underlying form of neonatal diabetes revealed Posted: 08 Sep 2009 05:00 PM PDT US researchers have discovered a novel molecular mechanism that regulates specialized pancreatic cells and insulin secretion and may underlie a form of neonatal diabetes mellitus.

Peri-procedural myocardial necrosis may be worse with CABG than PCI Posted: 08 Sep 2009 05:00 PM PDT Peri-procedural myocardial necrosis, as indicated by elevations in cardiac biomarkers, is worse among patients undergoing coronary artery bypass graft surgery than among those treated by percutaneous coronary intervention, study findings suggest.

Depression severity, persistence linked to increased post-ACS mortality Posted: 08 Sep 2009 05:00 PM PDT Clinical researchers report that severe depression within a few weeks after hospitalization for acute coronary syndrome, and the failure of depression to improve during the following 6 months, are associated with a doubling of mortality long term.

Seroma volume decreases during WBRT Posted: 08 Sep 2009 05:00 PM PDT Seroma volume in the breast changes substantially during whole-breast radiation therapy, and can impact the accuracy of boost irradiation planning, say researchers.

BMI and prostate weight indicate increased blood loss in prostate surgery Posted: 07 Sep 2009 05:00 PM PDT A high body mass index and large prostate weight are associated with increased estimated blood loss during radical retropubic prostatectomy, say US researchers investigating pre-operative predictors for EBL.

Obesity associated with aggressive prostate cancer Posted: 07 Sep 2009 05:00 PM PDT Obese men undergoing radical prostatectomy for prostate cancer have higher-grade and larger tumors, and more of their prostate affected by cancer than normal weight men, US researchers report.

SLN procedure has not led to breast cancer stage migration Posted: 07 Sep 2009 05:00 PM PDT Intensified examination of the sentinel lymph node has recently led to the detection of more tumor-affected lymph nodes in patients with breast cancer, research shows.

Prostate cancer treatment preferences affected by information sources Posted: 06 Sep 2009 05:00 PM PDT Men with newly-diagnosed localized prostate cancer consult a wide variety of information sources before deciding on their preferred treatment option, research findings suggest.

Confirmatory tumor biopsy may alter metastatic breast cancer management Posted: 06 Sep 2009 05:00 PM PDT Canadian researchers have found substantial discordance in receptor status between primary tumor and suspected metastases in women with breast cancer.

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