Medical News

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• Fixed-ratio criterion overestimates COPD prevalence
• Early daycare has no impact on childhood asthma, allergy risk
• Exercise challenge test protocol under scrutiny
• Non-cardiac chest pain has different characteristics to GERD
• Endoscopic treatment ‘reasonable’ for mucosal esophageal adenocarcinoma
• Fat intake may affect Crohn’s disease activity through genes
• PTSD increases suicide risk, worsens outcome in BD
• European CRT survey reveals widespread off-label CRT use
• Gray matter abnormalities differ in early, late psychosis vulnerability states
• Neurological signs in adolescent psychosis point to brain structure defects
• Brain volume changes in bipolar disorder linked to age and illness duration
• Outcomes worse with persistent substance misuse in first-episode psychosis
• Bipolar disorder patients affected by pain interference
• Childhood coordination deficits point to later schizophrenia
• Right prefrontal repetitive TMS may benefit bipolar mania patients

Fixed-ratio criterion overestimates COPD prevalence Posted: 13 Sep 2009 05:00 PM PDT Using a fixed cutoff with the FEV1/FVC ratio to diagnose chronic obstructive pulmonary disease overestimates the burden of disease, especially in older individuals, researchers have shown.

Early daycare has no impact on childhood asthma, allergy risk Posted: 13 Sep 2009 05:00 PM PDT Children who attend daycare in early life experience more wheezing until the age of 5 years but thereafter have no more or less asthma or allergies than children who do not attend daycare, a prospective study has found.

Exercise challenge test protocol under scrutiny Posted: 13 Sep 2009 05:00 PM PDT Results from the exercise challenge test to assess pediatric asthma must be interpreted in light of the child's age, Israeli researchers believe.

Non-cardiac chest pain has different characteristics to GERD Posted: 13 Sep 2009 05:00 PM PDT Non-cardiac chest pain has different clinical characteristics to gastroesophageal reflux disease although both have a similar benign prognosis, researchers report.

Endoscopic treatment ‘reasonable’ for mucosal esophageal adenocarcinoma Posted: 13 Sep 2009 05:00 PM PDT Endoscopic and surgical treatment for mucosal esophageal adenocarcinoma appear to result in similar overall survival and comparable low recurrence rates, research suggests.

Fat intake may affect Crohn’s disease activity through genes Posted: 13 Sep 2009 05:00 PM PDT Different types of fat in the diet can interact with cytokine genotype to affect the activity of Crohn's disease, research indicates.

PTSD increases suicide risk, worsens outcome in BD Posted: 10 Sep 2009 05:00 PM PDT Study results suggest that bipolar patients have a poorer outcome if they have comorbid post-traumatic stress disorder, with a lower likelihood of recovery, increase in rapid cycling periods and suicide attempts, and an overall worse quality of life.

European CRT survey reveals widespread off-label CRT use Posted: 10 Sep 2009 05:00 PM PDT Results of a Europe-wide survey suggest that clinicians are exploring wider indications for cardiac resynchronization therapy in their patients than are currently fully supported by the evidence from clinical trials.

Gray matter abnormalities differ in early, late psychosis vulnerability states Posted: 10 Sep 2009 05:00 PM PDT Structural brain abnormalities linked to an "early" at-risk mental state may dictate an elevated susceptibility to psychosis, while those seen during a "late" state may indicate a subsequent transition to psychosis, suggest study results.

Neurological signs in adolescent psychosis point to brain structure defects Posted: 09 Sep 2009 05:00 PM PDT Region-specific structural brain deficits in adolescents with first-episode psychosis are associated with the severity of neurological soft signs, potentially providing a marker for such deficits, conclude Spanish scientists.

Brain volume changes in bipolar disorder linked to age and illness duration Posted: 09 Sep 2009 05:00 PM PDT Bipolar disorder patients have significant brain volume changes compared with healthy individuals that are linked to age and duration of illness, but the changes do not appear to be diagnostically specific, say UK researchers.

Outcomes worse with persistent substance misuse in first-episode psychosis Posted: 08 Sep 2009 05:00 PM PDT First-episode psychosis patients with persistent substance misuse have worse symptoms, outcomes, and relapse rates than patients without substance misuse, say UK scientists who call for targeted interventions.

Bipolar disorder patients affected by pain interference Posted: 08 Sep 2009 05:00 PM PDT Bipolar disorder patients report more interference from pain than those with major depressive disorder or anxiety disorders, and such pain is linked to medical and psychiatric comorbidities, conclude US researchers.

Childhood coordination deficits point to later schizophrenia Posted: 07 Sep 2009 05:00 PM PDT Children who later develop schizophrenia spectrum disorder are significantly more likely to display coordination deficits than children who do not develop a mental illness, researchers have discovered.

Right prefrontal repetitive TMS may benefit bipolar mania patients Posted: 07 Sep 2009 05:00 PM PDT Bipolar mania patients may benefit from high-frequency, supra-threshold, right prefontal repetitive transcranial magnetic stimulation as an adjunct to pharmacotherapy, the results of an Indian study indicate.

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